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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-65738686-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=65738686&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 65738686,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000443035.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "NM_001320835.1",
"protein_id": "NP_001307764.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1907,
"cds_start": -4,
"cds_end": null,
"cds_length": 5724,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8837,
"mane_select": "ENST00000443035.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "ENST00000443035.8",
"protein_id": "ENSP00000391167.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1907,
"cds_start": -4,
"cds_end": null,
"cds_length": 5724,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8837,
"mane_select": "NM_001320835.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "ENST00000431932.6",
"protein_id": "ENSP00000396830.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1863,
"cds_start": -4,
"cds_end": null,
"cds_length": 5592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5875,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "ENST00000564674.5",
"protein_id": "ENSP00000457358.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1000,
"cds_start": -4,
"cds_end": null,
"cds_length": 3004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3389,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "ENST00000635620.2",
"protein_id": "ENSP00000489304.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1915,
"cds_start": -4,
"cds_end": null,
"cds_length": 5748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5884,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "NM_001144823.2",
"protein_id": "NP_001138295.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1906,
"cds_start": -4,
"cds_end": null,
"cds_length": 5721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8834,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "NM_001376919.1",
"protein_id": "NP_001363848.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1863,
"cds_start": -4,
"cds_end": null,
"cds_length": 5592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8705,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "NM_001376920.1",
"protein_id": "NP_001363849.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1863,
"cds_start": -4,
"cds_end": null,
"cds_length": 5592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8626,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "NM_005848.4",
"protein_id": "NP_005839.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1863,
"cds_start": -4,
"cds_end": null,
"cds_length": 5592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "n.1100+20T>C",
"hgvs_p": null,
"transcript": "ENST00000568515.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2655,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RAB11A",
"gene_hgnc_id": 9760,
"hgvs_c": "n.68+12565A>G",
"hgvs_p": null,
"transcript": "ENST00000569304.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 347,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432086.1",
"protein_id": "XP_047288042.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1916,
"cds_start": -4,
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"cdna_start": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432087.1",
"protein_id": "XP_047288043.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1916,
"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432088.1",
"protein_id": "XP_047288044.1",
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},
{
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],
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"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
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"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432089.1",
"protein_id": "XP_047288045.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 34,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432090.1",
"protein_id": "XP_047288046.1",
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},
{
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],
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"intron_rank": 5,
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"gene_symbol": "DENND4A",
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"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432091.1",
"protein_id": "XP_047288047.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 34,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432092.1",
"protein_id": "XP_047288048.1",
"transcript_support_level": null,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 35,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
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"hgvs_c": "c.801+20T>C",
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"transcript": "XM_047432093.1",
"protein_id": "XP_047288049.1",
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},
{
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],
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"intron_rank": 5,
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"gene_symbol": "DENND4A",
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"hgvs_c": "c.801+20T>C",
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"transcript": "XM_005254120.6",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 7,
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"gene_symbol": "DENND4A",
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"hgvs_c": "c.801+20T>C",
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"transcript": "XM_047432094.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432095.1",
"protein_id": "XP_047288051.1",
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"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "DENND4A",
"gene_hgnc_id": 24321,
"hgvs_c": "c.801+20T>C",
"hgvs_p": null,
"transcript": "XM_047432096.1",
"protein_id": "XP_047288052.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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}