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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-66333132-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=66333132&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 66333132,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001143688.3",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2985G>A",
"hgvs_p": "p.Glu995Glu",
"transcript": "NM_001143688.3",
"protein_id": "NP_001137160.1",
"transcript_support_level": null,
"aa_start": 995,
"aa_end": null,
"aa_length": 1054,
"cds_start": 2985,
"cds_end": null,
"cds_length": 3165,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000319212.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001143688.3"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2985G>A",
"hgvs_p": "p.Glu995Glu",
"transcript": "ENST00000319212.9",
"protein_id": "ENSP00000321711.4",
"transcript_support_level": 5,
"aa_start": 995,
"aa_end": null,
"aa_length": 1054,
"cds_start": 2985,
"cds_end": null,
"cds_length": 3165,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001143688.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000319212.9"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2736G>A",
"hgvs_p": "p.Glu912Glu",
"transcript": "ENST00000319194.9",
"protein_id": "ENSP00000321583.5",
"transcript_support_level": 1,
"aa_start": 912,
"aa_end": null,
"aa_length": 971,
"cds_start": 2736,
"cds_end": null,
"cds_length": 2916,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000319194.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "n.*2495G>A",
"hgvs_p": null,
"transcript": "ENST00000530537.1",
"protein_id": "ENSP00000432407.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000530537.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "n.*2495G>A",
"hgvs_p": null,
"transcript": "ENST00000530537.1",
"protein_id": "ENSP00000432407.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000530537.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.3015G>A",
"hgvs_p": "p.Glu1005Glu",
"transcript": "ENST00000904294.1",
"protein_id": "ENSP00000574353.1",
"transcript_support_level": null,
"aa_start": 1005,
"aa_end": null,
"aa_length": 1064,
"cds_start": 3015,
"cds_end": null,
"cds_length": 3195,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904294.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.3000G>A",
"hgvs_p": "p.Glu1000Glu",
"transcript": "ENST00000904296.1",
"protein_id": "ENSP00000574355.1",
"transcript_support_level": null,
"aa_start": 1000,
"aa_end": null,
"aa_length": 1059,
"cds_start": 3000,
"cds_end": null,
"cds_length": 3180,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904296.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2988G>A",
"hgvs_p": "p.Glu996Glu",
"transcript": "ENST00000904298.1",
"protein_id": "ENSP00000574357.1",
"transcript_support_level": null,
"aa_start": 996,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2988,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904298.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2982G>A",
"hgvs_p": "p.Glu994Glu",
"transcript": "ENST00000962294.1",
"protein_id": "ENSP00000632353.1",
"transcript_support_level": null,
"aa_start": 994,
"aa_end": null,
"aa_length": 1053,
"cds_start": 2982,
"cds_end": null,
"cds_length": 3162,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962294.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2934G>A",
"hgvs_p": "p.Glu978Glu",
"transcript": "NM_001323944.2",
"protein_id": "NP_001310873.1",
"transcript_support_level": null,
"aa_start": 978,
"aa_end": null,
"aa_length": 1037,
"cds_start": 2934,
"cds_end": null,
"cds_length": 3114,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001323944.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2919G>A",
"hgvs_p": "p.Glu973Glu",
"transcript": "ENST00000926559.1",
"protein_id": "ENSP00000596618.1",
"transcript_support_level": null,
"aa_start": 973,
"aa_end": null,
"aa_length": 1032,
"cds_start": 2919,
"cds_end": null,
"cds_length": 3099,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926559.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2895G>A",
"hgvs_p": "p.Glu965Glu",
"transcript": "ENST00000962295.1",
"protein_id": "ENSP00000632354.1",
"transcript_support_level": null,
"aa_start": 965,
"aa_end": null,
"aa_length": 1024,
"cds_start": 2895,
"cds_end": null,
"cds_length": 3075,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962295.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2892G>A",
"hgvs_p": "p.Glu964Glu",
"transcript": "ENST00000904297.1",
"protein_id": "ENSP00000574356.1",
"transcript_support_level": null,
"aa_start": 964,
"aa_end": null,
"aa_length": 1023,
"cds_start": 2892,
"cds_end": null,
"cds_length": 3072,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904297.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2889G>A",
"hgvs_p": "p.Glu963Glu",
"transcript": "ENST00000904295.1",
"protein_id": "ENSP00000574354.1",
"transcript_support_level": null,
"aa_start": 963,
"aa_end": null,
"aa_length": 1022,
"cds_start": 2889,
"cds_end": null,
"cds_length": 3069,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904295.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2808G>A",
"hgvs_p": "p.Glu936Glu",
"transcript": "ENST00000904293.1",
"protein_id": "ENSP00000574352.1",
"transcript_support_level": null,
"aa_start": 936,
"aa_end": null,
"aa_length": 995,
"cds_start": 2808,
"cds_end": null,
"cds_length": 2988,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904293.1"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2805G>A",
"hgvs_p": "p.Glu935Glu",
"transcript": "NM_001323948.2",
"protein_id": "NP_001310877.1",
"transcript_support_level": null,
"aa_start": 935,
"aa_end": null,
"aa_length": 994,
"cds_start": 2805,
"cds_end": null,
"cds_length": 2985,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001323948.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2736G>A",
"hgvs_p": "p.Glu912Glu",
"transcript": "NM_001323936.2",
"protein_id": "NP_001310865.1",
"transcript_support_level": null,
"aa_start": 912,
"aa_end": null,
"aa_length": 971,
"cds_start": 2736,
"cds_end": null,
"cds_length": 2916,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001323936.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2736G>A",
"hgvs_p": "p.Glu912Glu",
"transcript": "NM_001323945.2",
"protein_id": "NP_001310874.1",
"transcript_support_level": null,
"aa_start": 912,
"aa_end": null,
"aa_length": 971,
"cds_start": 2736,
"cds_end": null,
"cds_length": 2916,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001323945.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2736G>A",
"hgvs_p": "p.Glu912Glu",
"transcript": "NM_133375.5",
"protein_id": "NP_588616.1",
"transcript_support_level": null,
"aa_start": 912,
"aa_end": null,
"aa_length": 971,
"cds_start": 2736,
"cds_end": null,
"cds_length": 2916,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_133375.5"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2607G>A",
"hgvs_p": "p.Glu869Glu",
"transcript": "NM_001323937.2",
"protein_id": "NP_001310866.1",
"transcript_support_level": null,
"aa_start": 869,
"aa_end": null,
"aa_length": 928,
"cds_start": 2607,
"cds_end": null,
"cds_length": 2787,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001323937.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2583G>A",
"hgvs_p": "p.Glu861Glu",
"transcript": "NM_001323938.2",
"protein_id": "NP_001310867.1",
"transcript_support_level": null,
"aa_start": 861,
"aa_end": null,
"aa_length": 920,
"cds_start": 2583,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001323938.2"
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DIS3L",
"gene_hgnc_id": 28698,
"hgvs_c": "c.2583G>A",
"hgvs_p": "p.Glu861Glu",
"transcript": "NM_001323939.2",
"protein_id": "NP_001310868.1",
"transcript_support_level": null,
"aa_start": 861,
"aa_end": null,
"aa_length": 920,
"cds_start": 2583,
"cds_end": null,
"cds_length": 2763,
"cdna_start": null,
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"cdna_length": null,
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"splice_prediction_selected": "Benign",
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"phylop100way_prediction": "Benign",
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"acmg_by_gene": [
{
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"BP7",
"BA1"
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"verdict": "Benign",
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"clinvar_disease": "",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}