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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-66349394-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=66349394&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 66349394,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_017858.3",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "NM_017858.3",
"protein_id": "NP_060328.3",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000261881.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_017858.3"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000261881.9",
"protein_id": "ENSP00000261881.4",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_017858.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000261881.9"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "NM_001398281.1",
"protein_id": "NP_001385210.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001398281.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "NM_001398282.1",
"protein_id": "NP_001385211.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001398282.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "NM_001398283.1",
"protein_id": "NP_001385212.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001398283.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "NM_001398284.1",
"protein_id": "NP_001385213.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001398284.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000851323.1",
"protein_id": "ENSP00000521382.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851323.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000851324.1",
"protein_id": "ENSP00000521383.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851324.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912702.1",
"protein_id": "ENSP00000582761.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912702.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912703.1",
"protein_id": "ENSP00000582762.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912703.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912704.1",
"protein_id": "ENSP00000582763.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912704.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912705.1",
"protein_id": "ENSP00000582764.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912705.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912706.1",
"protein_id": "ENSP00000582765.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912706.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912707.1",
"protein_id": "ENSP00000582766.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912707.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912708.1",
"protein_id": "ENSP00000582767.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912708.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912710.1",
"protein_id": "ENSP00000582769.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912710.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000912711.1",
"protein_id": "ENSP00000582770.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912711.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000955702.1",
"protein_id": "ENSP00000625761.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955702.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000955703.1",
"protein_id": "ENSP00000625762.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 301,
"cds_start": 332,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955703.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.332C>G",
"hgvs_p": "p.Ala111Gly",
"transcript": "ENST00000562124.5",
"protein_id": "ENSP00000457406.1",
"transcript_support_level": 5,
"aa_start": 111,
"aa_end": null,
"aa_length": 293,
"cds_start": 332,
"cds_end": null,
"cds_length": 883,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000562124.5"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.29C>G",
"hgvs_p": "p.Ala10Gly",
"transcript": "NM_001289986.2",
"protein_id": "NP_001276915.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 200,
"cds_start": 29,
"cds_end": null,
"cds_length": 603,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001289986.2"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TIPIN",
"gene_hgnc_id": 30750,
"hgvs_c": "c.29C>G",
"hgvs_p": "p.Ala10Gly",
"transcript": "NM_001398285.1",
"protein_id": "NP_001385214.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 200,
"cds_start": 29,
"cds_end": null,
"cds_length": 603,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001398285.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
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}
],
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}