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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-67692480-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=67692480&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 67692480,
"ref": "C",
"alt": "T",
"effect": "splice_region_variant,synonymous_variant",
"transcript": "NM_145160.3",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "NM_145160.3",
"protein_id": "NP_660143.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 448,
"cds_start": 849,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000178640.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_145160.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000178640.10",
"protein_id": "ENSP00000178640.5",
"transcript_support_level": 1,
"aa_start": 283,
"aa_end": null,
"aa_length": 448,
"cds_start": 849,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_145160.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000178640.10"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000395476.6",
"protein_id": "ENSP00000378859.2",
"transcript_support_level": 1,
"aa_start": 283,
"aa_end": null,
"aa_length": 438,
"cds_start": 849,
"cds_end": null,
"cds_length": 1317,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000395476.6"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000952141.1",
"protein_id": "ENSP00000622200.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 505,
"cds_start": 849,
"cds_end": null,
"cds_length": 1518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952141.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879775.1",
"protein_id": "ENSP00000549834.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 490,
"cds_start": 849,
"cds_end": null,
"cds_length": 1473,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879775.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879770.1",
"protein_id": "ENSP00000549829.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 480,
"cds_start": 849,
"cds_end": null,
"cds_length": 1443,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879770.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000952139.1",
"protein_id": "ENSP00000622198.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 468,
"cds_start": 849,
"cds_end": null,
"cds_length": 1407,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952139.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879777.1",
"protein_id": "ENSP00000549836.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 463,
"cds_start": 849,
"cds_end": null,
"cds_length": 1392,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879777.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879778.1",
"protein_id": "ENSP00000549837.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 458,
"cds_start": 849,
"cds_end": null,
"cds_length": 1377,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879778.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879773.1",
"protein_id": "ENSP00000549832.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 453,
"cds_start": 849,
"cds_end": null,
"cds_length": 1362,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879773.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000952140.1",
"protein_id": "ENSP00000622199.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 447,
"cds_start": 849,
"cds_end": null,
"cds_length": 1344,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952140.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879774.1",
"protein_id": "ENSP00000549833.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 439,
"cds_start": 849,
"cds_end": null,
"cds_length": 1320,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879774.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "NM_002757.4",
"protein_id": "NP_002748.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 438,
"cds_start": 849,
"cds_end": null,
"cds_length": 1317,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002757.4"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879769.1",
"protein_id": "ENSP00000549828.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 429,
"cds_start": 849,
"cds_end": null,
"cds_length": 1290,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879769.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000952137.1",
"protein_id": "ENSP00000622196.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 428,
"cds_start": 849,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952137.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000879772.1",
"protein_id": "ENSP00000549831.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 424,
"cds_start": 849,
"cds_end": null,
"cds_length": 1275,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879772.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000952135.1",
"protein_id": "ENSP00000622194.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 418,
"cds_start": 849,
"cds_end": null,
"cds_length": 1257,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952135.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.849C>T",
"hgvs_p": "p.Asp283Asp",
"transcript": "ENST00000952136.1",
"protein_id": "ENSP00000622195.1",
"transcript_support_level": null,
"aa_start": 283,
"aa_end": null,
"aa_length": 414,
"cds_start": 849,
"cds_end": null,
"cds_length": 1245,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952136.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.744C>T",
"hgvs_p": "p.Asp248Asp",
"transcript": "ENST00000879780.1",
"protein_id": "ENSP00000549839.1",
"transcript_support_level": null,
"aa_start": 248,
"aa_end": null,
"aa_length": 413,
"cds_start": 744,
"cds_end": null,
"cds_length": 1242,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879780.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.741C>T",
"hgvs_p": "p.Asp247Asp",
"transcript": "NM_001206804.2",
"protein_id": "NP_001193733.1",
"transcript_support_level": null,
"aa_start": 247,
"aa_end": null,
"aa_length": 412,
"cds_start": 741,
"cds_end": null,
"cds_length": 1239,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001206804.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP2K5",
"gene_hgnc_id": 6845,
"hgvs_c": "c.741C>T",
"hgvs_p": "p.Asp247Asp",
"transcript": "ENST00000354498.9",
"protein_id": "ENSP00000346493.5",
"transcript_support_level": 2,
"aa_start": 247,
"aa_end": null,
"aa_length": 412,
"cds_start": 741,
"cds_end": null,
"cds_length": 1239,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354498.9"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
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{
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],
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"clinvar_classification": "Benign",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "B:1",
"phenotype_combined": "not provided",
"pathogenicity_classification_combined": "Benign",
"custom_annotations": null
}
],
"message": null
}