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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-69426090-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=69426090&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 69426090,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000679126.1",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Leu266Pro",
"transcript": "NM_001367805.3",
"protein_id": "NP_001354734.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 974,
"cds_start": 797,
"cds_end": null,
"cds_length": 2925,
"cdna_start": 914,
"cdna_end": null,
"cdna_length": 3660,
"mane_select": "ENST00000679126.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Leu266Pro",
"transcript": "ENST00000679126.1",
"protein_id": "ENSP00000504770.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 974,
"cds_start": 797,
"cds_end": null,
"cds_length": 2925,
"cdna_start": 914,
"cdna_end": null,
"cdna_length": 3660,
"mane_select": "NM_001367805.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "ENST00000260363.9",
"protein_id": "ENSP00000260363.4",
"transcript_support_level": 1,
"aa_start": 252,
"aa_end": null,
"aa_length": 960,
"cds_start": 755,
"cds_end": null,
"cds_length": 2883,
"cdna_start": 975,
"cdna_end": null,
"cdna_length": 3723,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "ENST00000352331.8",
"protein_id": "ENSP00000304978.6",
"transcript_support_level": 1,
"aa_start": 252,
"aa_end": null,
"aa_length": 856,
"cds_start": 755,
"cds_end": null,
"cds_length": 2571,
"cdna_start": 917,
"cdna_end": null,
"cdna_length": 3351,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Leu266Pro",
"transcript": "ENST00000559279.6",
"protein_id": "ENSP00000453386.2",
"transcript_support_level": 1,
"aa_start": 266,
"aa_end": null,
"aa_length": 810,
"cds_start": 797,
"cds_end": null,
"cds_length": 2433,
"cdna_start": 904,
"cdna_end": null,
"cdna_length": 3129,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "n.797T>C",
"hgvs_p": null,
"transcript": "ENST00000558346.5",
"protein_id": "ENSP00000453576.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1656,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "n.*288T>C",
"hgvs_p": null,
"transcript": "ENST00000561089.5",
"protein_id": "ENSP00000453629.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2743,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "n.*288T>C",
"hgvs_p": null,
"transcript": "ENST00000561089.5",
"protein_id": "ENSP00000453629.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2743,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "NM_138555.4",
"protein_id": "NP_612565.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 960,
"cds_start": 755,
"cds_end": null,
"cds_length": 2883,
"cdna_start": 872,
"cdna_end": null,
"cdna_length": 3620,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "ENST00000647715.1",
"protein_id": "ENSP00000497065.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 960,
"cds_start": 755,
"cds_end": null,
"cds_length": 2883,
"cdna_start": 872,
"cdna_end": null,
"cdna_length": 3620,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "ENST00000395392.6",
"protein_id": "ENSP00000378790.2",
"transcript_support_level": 5,
"aa_start": 252,
"aa_end": null,
"aa_length": 952,
"cds_start": 755,
"cds_end": null,
"cds_length": 2859,
"cdna_start": 928,
"cdna_end": null,
"cdna_length": 3357,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "NM_001367804.2",
"protein_id": "NP_001354733.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 911,
"cds_start": 755,
"cds_end": null,
"cds_length": 2736,
"cdna_start": 872,
"cdna_end": null,
"cdna_length": 3538,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "NM_004856.7",
"protein_id": "NP_004847.2",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 856,
"cds_start": 755,
"cds_end": null,
"cds_length": 2571,
"cdna_start": 872,
"cdna_end": null,
"cdna_length": 3308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.425T>C",
"hgvs_p": "p.Leu142Pro",
"transcript": "NM_001281301.2",
"protein_id": "NP_001268230.1",
"transcript_support_level": null,
"aa_start": 142,
"aa_end": null,
"aa_length": 766,
"cds_start": 425,
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"cds_length": 2301,
"cdna_start": 735,
"cdna_end": null,
"cdna_length": 3231,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Leu266Pro",
"transcript": "XM_005254797.4",
"protein_id": "XP_005254854.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 925,
"cds_start": 797,
"cds_end": null,
"cds_length": 2778,
"cdna_start": 914,
"cdna_end": null,
"cdna_length": 3580,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Leu266Pro",
"transcript": "XM_005254798.4",
"protein_id": "XP_005254855.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 890,
"cds_start": 797,
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"cdna_start": 914,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.755T>C",
"hgvs_p": "p.Leu252Pro",
"transcript": "XM_047433367.1",
"protein_id": "XP_047289323.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 876,
"cds_start": 755,
"cds_end": null,
"cds_length": 2631,
"cdna_start": 872,
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"cdna_length": 3368,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.797T>C",
"hgvs_p": "p.Leu266Pro",
"transcript": "XM_005254799.4",
"protein_id": "XP_005254856.1",
"transcript_support_level": null,
"aa_start": 266,
"aa_end": null,
"aa_length": 870,
"cds_start": 797,
"cds_end": null,
"cds_length": 2613,
"cdna_start": 914,
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"cdna_length": 3350,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.467T>C",
"hgvs_p": "p.Leu156Pro",
"transcript": "XM_047433368.1",
"protein_id": "XP_047289324.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
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"cds_start": 467,
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"cdna_start": 579,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.434T>C",
"hgvs_p": "p.Leu145Pro",
"transcript": "XM_047433369.1",
"protein_id": "XP_047289325.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
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"cds_start": 434,
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"cdna_start": 868,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.425T>C",
"hgvs_p": "p.Leu142Pro",
"transcript": "XM_047433370.1",
"protein_id": "XP_047289326.1",
"transcript_support_level": null,
"aa_start": 142,
"aa_end": null,
"aa_length": 850,
"cds_start": 425,
"cds_end": null,
"cds_length": 2553,
"cdna_start": 537,
"cdna_end": null,
"cdna_length": 3285,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.467T>C",
"hgvs_p": "p.Leu156Pro",
"transcript": "XM_047433371.1",
"protein_id": "XP_047289327.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 760,
"cds_start": 467,
"cds_end": null,
"cds_length": 2283,
"cdna_start": 579,
"cdna_end": null,
"cdna_length": 3015,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF23",
"gene_hgnc_id": 6392,
"hgvs_c": "c.797T>C",
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{
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}
],
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}