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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 15-71877125-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=71877125&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "15",
      "pos": 71877125,
      "ref": "G",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "NM_006901.4",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": 31,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.5931+915C>G",
          "hgvs_p": null,
          "transcript": "NM_006901.4",
          "protein_id": "NP_008832.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 2548,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 7647,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000356056.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_006901.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": 31,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.5931+915C>G",
          "hgvs_p": null,
          "transcript": "ENST00000356056.10",
          "protein_id": "ENSP00000348349.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 2548,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 7647,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_006901.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000356056.10"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": 31,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.5931+915C>G",
          "hgvs_p": null,
          "transcript": "ENST00000564571.5",
          "protein_id": "ENSP00000456192.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 2396,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 7191,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000564571.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": 8,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.2478+915C>G",
          "hgvs_p": null,
          "transcript": "ENST00000561618.5",
          "protein_id": "ENSP00000457945.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1397,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4194,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000561618.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": 33,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.6063+915C>G",
          "hgvs_p": null,
          "transcript": "ENST00000971716.1",
          "protein_id": "ENSP00000641775.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 2592,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 7779,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000971716.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": 29,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.5970+915C>G",
          "hgvs_p": null,
          "transcript": "ENST00000922047.1",
          "protein_id": "ENSP00000592106.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 2561,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 7686,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000922047.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": 30,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.5874+915C>G",
          "hgvs_p": null,
          "transcript": "ENST00000971717.1",
          "protein_id": "ENSP00000641776.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 2529,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 7590,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000971717.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": 32,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.6147+915C>G",
          "hgvs_p": null,
          "transcript": "XM_011521613.4",
          "protein_id": "XP_011519915.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 2638,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 7917,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_011521613.4"
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        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 45,
          "intron_rank": 33,
          "intron_rank_end": null,
          "gene_symbol": "MYO9A",
          "gene_hgnc_id": 7608,
          "hgvs_c": "c.6147+915C>G",
          "hgvs_p": null,
          "transcript": "XM_011521614.4",
          "protein_id": "XP_011519916.1",
          "transcript_support_level": null,
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          "aa_length": 2638,
          "cds_start": null,
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          "cdna_start": null,
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        {
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          "consequences": [
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          ],
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          "gene_symbol": "MYO9A",
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          "hgvs_c": "c.6147+915C>G",
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          "cds_start": null,
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}