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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-73178316-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=73178316&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 73178316,
"ref": "A",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000261908.11",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "NM_002499.4",
"protein_id": "NP_002490.2",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1461,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4386,
"cdna_start": 1393,
"cdna_end": null,
"cdna_length": 7108,
"mane_select": "ENST00000261908.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "ENST00000261908.11",
"protein_id": "ENSP00000261908.6",
"transcript_support_level": 1,
"aa_start": 394,
"aa_end": null,
"aa_length": 1461,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4386,
"cdna_start": 1393,
"cdna_end": null,
"cdna_length": 7108,
"mane_select": "NM_002499.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "ENST00000558964.5",
"protein_id": "ENSP00000453200.1",
"transcript_support_level": 1,
"aa_start": 394,
"aa_end": null,
"aa_length": 1450,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4353,
"cdna_start": 1246,
"cdna_end": null,
"cdna_length": 4441,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "ENST00000560262.5",
"protein_id": "ENSP00000453317.1",
"transcript_support_level": 1,
"aa_start": 394,
"aa_end": null,
"aa_length": 1408,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4227,
"cdna_start": 1246,
"cdna_end": null,
"cdna_length": 4315,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.208A>T",
"hgvs_p": "p.Asn70Tyr",
"transcript": "ENST00000560328.1",
"protein_id": "ENSP00000454024.1",
"transcript_support_level": 1,
"aa_start": 70,
"aa_end": null,
"aa_length": 1130,
"cds_start": 208,
"cds_end": null,
"cds_length": 3393,
"cdna_start": 208,
"cdna_end": null,
"cdna_length": 5895,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "NM_001419531.1",
"protein_id": "NP_001406460.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1481,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4446,
"cdna_start": 1435,
"cdna_end": null,
"cdna_length": 7210,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "ENST00000339362.9",
"protein_id": "ENSP00000341198.5",
"transcript_support_level": 5,
"aa_start": 394,
"aa_end": null,
"aa_length": 1461,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4386,
"cdna_start": 1627,
"cdna_end": null,
"cdna_length": 7342,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "NM_001172624.2",
"protein_id": "NP_001166095.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1450,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4353,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 7145,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "NM_001172623.2",
"protein_id": "NP_001166094.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1408,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4227,
"cdna_start": 1393,
"cdna_end": null,
"cdna_length": 6949,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_011521628.3",
"protein_id": "XP_011519930.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1481,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4446,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 7239,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_011521629.3",
"protein_id": "XP_011519931.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1470,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4413,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 7206,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_011521630.3",
"protein_id": "XP_011519932.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1465,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4398,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 7191,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_047432586.1",
"protein_id": "XP_047288542.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1461,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4386,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 7179,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_017022232.2",
"protein_id": "XP_016877721.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1454,
"cds_start": 1180,
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"cdna_start": 1435,
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"cdna_length": 7130,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_047432587.1",
"protein_id": "XP_047288543.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1454,
"cds_start": 1180,
"cds_end": null,
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"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 7158,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_047432591.1",
"protein_id": "XP_047288547.1",
"transcript_support_level": null,
"aa_start": 394,
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"cdna_start": 1586,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_011521632.3",
"protein_id": "XP_011519934.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1447,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4344,
"cdna_start": 1463,
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"cdna_length": 7137,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_047432589.1",
"protein_id": "XP_047288545.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1445,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4338,
"cdna_start": 1463,
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"cdna_length": 7131,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_047432594.1",
"protein_id": "XP_047288550.1",
"transcript_support_level": null,
"aa_start": 394,
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"cdna_start": 1435,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_017022231.2",
"protein_id": "XP_016877720.1",
"transcript_support_level": null,
"aa_start": 394,
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"cds_start": 1180,
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"biotype": null,
"feature": null
},
{
"aa_ref": "N",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_047432597.1",
"protein_id": "XP_047288553.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1434,
"cds_start": 1180,
"cds_end": null,
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"cdna_start": 1435,
"cdna_end": null,
"cdna_length": 7070,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEO1",
"gene_hgnc_id": 7754,
"hgvs_c": "c.1180A>T",
"hgvs_p": "p.Asn394Tyr",
"transcript": "XM_047432590.1",
"protein_id": "XP_047288546.1",
"transcript_support_level": null,
"aa_start": 394,
"aa_end": null,
"aa_length": 1431,
"cds_start": 1180,
"cds_end": null,
"cds_length": 4296,
"cdna_start": 1463,
"cdna_end": null,
"cdna_length": 7089,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
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}