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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-74799310-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=74799310&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 74799310,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_004383.3",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_004383.3",
"protein_id": "NP_004374.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000220003.14",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004383.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000220003.14",
"protein_id": "ENSP00000220003.9",
"transcript_support_level": 1,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004383.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000220003.14"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001127190.2",
"protein_id": "NP_001120662.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127190.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001354988.2",
"protein_id": "NP_001341917.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354988.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387089.1",
"protein_id": "NP_001374018.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387089.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387090.1",
"protein_id": "NP_001374019.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387090.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387091.1",
"protein_id": "NP_001374020.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387091.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387092.1",
"protein_id": "NP_001374021.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387092.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387093.1",
"protein_id": "NP_001374022.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387093.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000439220.6",
"protein_id": "ENSP00000414764.2",
"transcript_support_level": 2,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000439220.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000567571.5",
"protein_id": "ENSP00000454906.1",
"transcript_support_level": 2,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000567571.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000858351.1",
"protein_id": "ENSP00000528410.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858351.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000858352.1",
"protein_id": "ENSP00000528411.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858352.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000858354.1",
"protein_id": "ENSP00000528413.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858354.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000858355.1",
"protein_id": "ENSP00000528414.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858355.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000858356.1",
"protein_id": "ENSP00000528415.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858356.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000858357.1",
"protein_id": "ENSP00000528416.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858357.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000931146.1",
"protein_id": "ENSP00000601205.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931146.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "ENST00000951979.1",
"protein_id": "ENSP00000622038.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 450,
"cds_start": 281,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951979.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387094.1",
"protein_id": "NP_001374023.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 449,
"cds_start": 281,
"cds_end": null,
"cds_length": 1350,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387094.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387095.1",
"protein_id": "NP_001374024.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 449,
"cds_start": 281,
"cds_end": null,
"cds_length": 1350,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387095.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CSK",
"gene_hgnc_id": 2444,
"hgvs_c": "c.281G>T",
"hgvs_p": "p.Arg94Leu",
"transcript": "NM_001387096.1",
"protein_id": "NP_001374025.1",
"transcript_support_level": null,
"aa_start": 94,
"aa_end": null,
"aa_length": 436,
"cds_start": 281,
"cds_end": null,
"cds_length": 1311,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387096.1"
},
{
"aa_ref": "R",
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{
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}
],
"message": null
}