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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-74890087-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=74890087&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 74890087,
"ref": "G",
"alt": "C",
"effect": "missense_variant,splice_region_variant",
"transcript": "ENST00000352410.9",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "NM_002435.3",
"protein_id": "NP_002426.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 423,
"cds_start": 14,
"cds_end": null,
"cds_length": 1272,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 5793,
"mane_select": "ENST00000352410.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000352410.9",
"protein_id": "ENSP00000318318.6",
"transcript_support_level": 1,
"aa_start": 5,
"aa_end": null,
"aa_length": 423,
"cds_start": 14,
"cds_end": null,
"cds_length": 1272,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 5793,
"mane_select": "NM_002435.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000323744.10",
"protein_id": "ENSP00000318192.6",
"transcript_support_level": 1,
"aa_start": 5,
"aa_end": null,
"aa_length": 362,
"cds_start": 14,
"cds_end": null,
"cds_length": 1089,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 1619,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000563422.5",
"protein_id": "ENSP00000457885.1",
"transcript_support_level": 1,
"aa_start": 5,
"aa_end": null,
"aa_length": 339,
"cds_start": 14,
"cds_end": null,
"cds_length": 1020,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 1481,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000566377.5",
"protein_id": "ENSP00000455405.1",
"transcript_support_level": 1,
"aa_start": 5,
"aa_end": null,
"aa_length": 287,
"cds_start": 14,
"cds_end": null,
"cds_length": 864,
"cdna_start": 49,
"cdna_end": null,
"cdna_length": 2809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-136G>C",
"hgvs_p": null,
"transcript": "NM_001330372.2",
"protein_id": "NP_001317301.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 403,
"cds_start": -4,
"cds_end": null,
"cds_length": 1212,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5882,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-136G>C",
"hgvs_p": null,
"transcript": "ENST00000563786.5",
"protein_id": "ENSP00000455241.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 403,
"cds_start": -4,
"cds_end": null,
"cds_length": 1212,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-9G>C",
"hgvs_p": null,
"transcript": "NM_001289156.2",
"protein_id": "NP_001276085.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 373,
"cds_start": -4,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-9G>C",
"hgvs_p": null,
"transcript": "ENST00000535694.5",
"protein_id": "ENSP00000440447.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 373,
"cds_start": -4,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1523,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "NM_001289157.2",
"protein_id": "NP_001276086.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 362,
"cds_start": 14,
"cds_end": null,
"cds_length": 1089,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 5610,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-21G>C",
"hgvs_p": null,
"transcript": "ENST00000562606.5",
"protein_id": "ENSP00000457020.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 319,
"cds_start": -4,
"cds_end": null,
"cds_length": 960,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1052,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-21G>C",
"hgvs_p": null,
"transcript": "ENST00000569931.5",
"protein_id": "ENSP00000455161.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 287,
"cds_start": -4,
"cds_end": null,
"cds_length": 866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 969,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "NM_001289155.2",
"protein_id": "NP_001276084.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 287,
"cds_start": 14,
"cds_end": null,
"cds_length": 864,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 5584,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000565576.5",
"protein_id": "ENSP00000454619.1",
"transcript_support_level": 2,
"aa_start": 5,
"aa_end": null,
"aa_length": 264,
"cds_start": 14,
"cds_end": null,
"cds_length": 795,
"cdna_start": 26,
"cdna_end": null,
"cdna_length": 1148,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-9G>C",
"hgvs_p": null,
"transcript": "ENST00000564003.5",
"protein_id": "ENSP00000454312.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 228,
"cds_start": -4,
"cds_end": null,
"cds_length": 687,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1195,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000568828.5",
"protein_id": "ENSP00000455065.1",
"transcript_support_level": 4,
"aa_start": 5,
"aa_end": null,
"aa_length": 184,
"cds_start": 14,
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"cds_length": 556,
"cdna_start": 36,
"cdna_end": null,
"cdna_length": 578,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000567132.5",
"protein_id": "ENSP00000455972.1",
"transcript_support_level": 4,
"aa_start": 5,
"aa_end": null,
"aa_length": 174,
"cds_start": 14,
"cds_end": null,
"cds_length": 527,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 559,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000569233.5",
"protein_id": "ENSP00000454622.1",
"transcript_support_level": 4,
"aa_start": 5,
"aa_end": null,
"aa_length": 173,
"cds_start": 14,
"cds_end": null,
"cds_length": 523,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 555,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.-18G>C",
"hgvs_p": null,
"transcript": "ENST00000564633.5",
"protein_id": "ENSP00000455383.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 172,
"cds_start": -4,
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"cds_length": 520,
"cdna_start": null,
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"cdna_length": 583,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000568907.5",
"protein_id": "ENSP00000457494.1",
"transcript_support_level": 4,
"aa_start": 5,
"aa_end": null,
"aa_length": 167,
"cds_start": 14,
"cds_end": null,
"cds_length": 505,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "c.14G>C",
"hgvs_p": "p.Arg5Pro",
"transcript": "ENST00000562800.5",
"protein_id": "ENSP00000457619.1",
"transcript_support_level": 3,
"aa_start": 5,
"aa_end": null,
"aa_length": 124,
"cds_start": 14,
"cds_end": null,
"cds_length": 375,
"cdna_start": 46,
"cdna_end": null,
"cdna_length": 407,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "n.14G>C",
"hgvs_p": null,
"transcript": "ENST00000561470.5",
"protein_id": "ENSP00000454267.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 851,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MPI",
"gene_hgnc_id": 7216,
"hgvs_c": "n.45G>C",
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}
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"message": null
}