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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 15-76381427-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=76381427&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "15",
      "pos": 76381427,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "ENST00000563290.6",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3656G>A",
          "hgvs_p": "p.Ser1219Asn",
          "transcript": "NM_020843.4",
          "protein_id": "NP_065894.2",
          "transcript_support_level": null,
          "aa_start": 1219,
          "aa_end": null,
          "aa_length": 1400,
          "cds_start": 3656,
          "cds_end": null,
          "cds_length": 4203,
          "cdna_start": 3757,
          "cdna_end": null,
          "cdna_length": 5033,
          "mane_select": "ENST00000563290.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3656G>A",
          "hgvs_p": "p.Ser1219Asn",
          "transcript": "ENST00000563290.6",
          "protein_id": "ENSP00000454973.1",
          "transcript_support_level": 5,
          "aa_start": 1219,
          "aa_end": null,
          "aa_length": 1400,
          "cds_start": 3656,
          "cds_end": null,
          "cds_length": 4203,
          "cdna_start": 3757,
          "cdna_end": null,
          "cdna_length": 5033,
          "mane_select": "NM_020843.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3656G>A",
          "hgvs_p": "p.Ser1219Asn",
          "transcript": "ENST00000324767.11",
          "protein_id": "ENSP00000326924.7",
          "transcript_support_level": 1,
          "aa_start": 1219,
          "aa_end": null,
          "aa_length": 1400,
          "cds_start": 3656,
          "cds_end": null,
          "cds_length": 4203,
          "cdna_start": 3715,
          "cdna_end": null,
          "cdna_length": 4707,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.2918G>A",
          "hgvs_p": "p.Ser973Asn",
          "transcript": "ENST00000538941.6",
          "protein_id": "ENSP00000442190.2",
          "transcript_support_level": 1,
          "aa_start": 973,
          "aa_end": null,
          "aa_length": 1154,
          "cds_start": 2918,
          "cds_end": null,
          "cds_length": 3465,
          "cdna_start": 3858,
          "cdna_end": null,
          "cdna_length": 4853,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3674G>A",
          "hgvs_p": "p.Ser1225Asn",
          "transcript": "NM_001353009.2",
          "protein_id": "NP_001339938.1",
          "transcript_support_level": null,
          "aa_start": 1225,
          "aa_end": null,
          "aa_length": 1406,
          "cds_start": 3674,
          "cds_end": null,
          "cds_length": 4221,
          "cdna_start": 3953,
          "cdna_end": null,
          "cdna_length": 5229,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3272G>A",
          "hgvs_p": "p.Ser1091Asn",
          "transcript": "NM_001353011.2",
          "protein_id": "NP_001339940.1",
          "transcript_support_level": null,
          "aa_start": 1091,
          "aa_end": null,
          "aa_length": 1272,
          "cds_start": 3272,
          "cds_end": null,
          "cds_length": 3819,
          "cdna_start": 3893,
          "cdna_end": null,
          "cdna_length": 5169,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3254G>A",
          "hgvs_p": "p.Ser1085Asn",
          "transcript": "NM_001353010.2",
          "protein_id": "NP_001339939.1",
          "transcript_support_level": null,
          "aa_start": 1085,
          "aa_end": null,
          "aa_length": 1266,
          "cds_start": 3254,
          "cds_end": null,
          "cds_length": 3801,
          "cdna_start": 3918,
          "cdna_end": null,
          "cdna_length": 5194,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3254G>A",
          "hgvs_p": "p.Ser1085Asn",
          "transcript": "NM_001353012.2",
          "protein_id": "NP_001339941.1",
          "transcript_support_level": null,
          "aa_start": 1085,
          "aa_end": null,
          "aa_length": 1266,
          "cds_start": 3254,
          "cds_end": null,
          "cds_length": 3801,
          "cdna_start": 3845,
          "cdna_end": null,
          "cdna_length": 5121,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.2918G>A",
          "hgvs_p": "p.Ser973Asn",
          "transcript": "NM_001145923.2",
          "protein_id": "NP_001139395.1",
          "transcript_support_level": null,
          "aa_start": 973,
          "aa_end": null,
          "aa_length": 1154,
          "cds_start": 2918,
          "cds_end": null,
          "cds_length": 3465,
          "cdna_start": 3858,
          "cdna_end": null,
          "cdna_length": 5134,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3749G>A",
          "hgvs_p": "p.Ser1250Asn",
          "transcript": "XM_047432620.1",
          "protein_id": "XP_047288576.1",
          "transcript_support_level": null,
          "aa_start": 1250,
          "aa_end": null,
          "aa_length": 1431,
          "cds_start": 3749,
          "cds_end": null,
          "cds_length": 4296,
          "cdna_start": 3835,
          "cdna_end": null,
          "cdna_length": 5111,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3731G>A",
          "hgvs_p": "p.Ser1244Asn",
          "transcript": "XM_047432621.1",
          "protein_id": "XP_047288577.1",
          "transcript_support_level": null,
          "aa_start": 1244,
          "aa_end": null,
          "aa_length": 1425,
          "cds_start": 3731,
          "cds_end": null,
          "cds_length": 4278,
          "cdna_start": 3817,
          "cdna_end": null,
          "cdna_length": 5093,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3626G>A",
          "hgvs_p": "p.Ser1209Asn",
          "transcript": "XM_047432622.1",
          "protein_id": "XP_047288578.1",
          "transcript_support_level": null,
          "aa_start": 1209,
          "aa_end": null,
          "aa_length": 1390,
          "cds_start": 3626,
          "cds_end": null,
          "cds_length": 4173,
          "cdna_start": 3763,
          "cdna_end": null,
          "cdna_length": 5039,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3608G>A",
          "hgvs_p": "p.Ser1203Asn",
          "transcript": "XM_047432623.1",
          "protein_id": "XP_047288579.1",
          "transcript_support_level": null,
          "aa_start": 1203,
          "aa_end": null,
          "aa_length": 1384,
          "cds_start": 3608,
          "cds_end": null,
          "cds_length": 4155,
          "cdna_start": 3745,
          "cdna_end": null,
          "cdna_length": 5021,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3593G>A",
          "hgvs_p": "p.Ser1198Asn",
          "transcript": "XM_047432624.1",
          "protein_id": "XP_047288580.1",
          "transcript_support_level": null,
          "aa_start": 1198,
          "aa_end": null,
          "aa_length": 1379,
          "cds_start": 3593,
          "cds_end": null,
          "cds_length": 4140,
          "cdna_start": 3679,
          "cdna_end": null,
          "cdna_length": 4955,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3575G>A",
          "hgvs_p": "p.Ser1192Asn",
          "transcript": "XM_047432625.1",
          "protein_id": "XP_047288581.1",
          "transcript_support_level": null,
          "aa_start": 1192,
          "aa_end": null,
          "aa_length": 1373,
          "cds_start": 3575,
          "cds_end": null,
          "cds_length": 4122,
          "cdna_start": 3661,
          "cdna_end": null,
          "cdna_length": 4937,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 26,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3500G>A",
          "hgvs_p": "p.Ser1167Asn",
          "transcript": "XM_047432626.1",
          "protein_id": "XP_047288582.1",
          "transcript_support_level": null,
          "aa_start": 1167,
          "aa_end": null,
          "aa_length": 1348,
          "cds_start": 3500,
          "cds_end": null,
          "cds_length": 4047,
          "cdna_start": 3559,
          "cdna_end": null,
          "cdna_length": 4835,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3272G>A",
          "hgvs_p": "p.Ser1091Asn",
          "transcript": "XM_011521653.4",
          "protein_id": "XP_011519955.1",
          "transcript_support_level": null,
          "aa_start": 1091,
          "aa_end": null,
          "aa_length": 1272,
          "cds_start": 3272,
          "cds_end": null,
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          "cdna_start": 3657,
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          "cdna_length": 4933,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.3254G>A",
          "hgvs_p": "p.Ser1085Asn",
          "transcript": "XM_017022273.2",
          "protein_id": "XP_016877762.1",
          "transcript_support_level": null,
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          "aa_end": null,
          "aa_length": 1266,
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          "cdna_start": 3639,
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          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
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          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.2936G>A",
          "hgvs_p": "p.Ser979Asn",
          "transcript": "XM_047432627.1",
          "protein_id": "XP_047288583.1",
          "transcript_support_level": null,
          "aa_start": 979,
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          "aa_length": 1160,
          "cds_start": 2936,
          "cds_end": null,
          "cds_length": 3483,
          "cdna_start": 3032,
          "cdna_end": null,
          "cdna_length": 4308,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.1814G>A",
          "hgvs_p": "p.Ser605Asn",
          "transcript": "XM_011521656.4",
          "protein_id": "XP_011519958.1",
          "transcript_support_level": null,
          "aa_start": 605,
          "aa_end": null,
          "aa_length": 786,
          "cds_start": 1814,
          "cds_end": null,
          "cds_length": 2361,
          "cdna_start": 1900,
          "cdna_end": null,
          "cdna_length": 3176,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "c.1580G>A",
          "hgvs_p": "p.Ser527Asn",
          "transcript": "XM_047432633.1",
          "protein_id": "XP_047288589.1",
          "transcript_support_level": null,
          "aa_start": 527,
          "aa_end": null,
          "aa_length": 708,
          "cds_start": 1580,
          "cds_end": null,
          "cds_length": 2127,
          "cdna_start": 2686,
          "cdna_end": null,
          "cdna_length": 3962,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "n.3720G>A",
          "hgvs_p": null,
          "transcript": "ENST00000303521.10",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5438,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 29,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "n.3864G>A",
          "hgvs_p": null,
          "transcript": "NR_148227.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5140,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCAPER",
          "gene_hgnc_id": 13081,
          "hgvs_c": "n.*137G>A",
          "hgvs_p": null,
          "transcript": "ENST00000567601.1",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 131,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "SCAPER",
      "gene_hgnc_id": 13081,
      "dbsnp": "rs1305542291",
      "frequency_reference_population": 0.0000018590678,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 3,
      "gnomad_exomes_af": 6.84197e-7,
      "gnomad_genomes_af": 0.0000131454,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": 2,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.38903266191482544,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.094,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.6565,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.35,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 7.52,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 2,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP5,BP4",
      "acmg_by_gene": [
        {
          "score": 2,
          "benign_score": 1,
          "pathogenic_score": 3,
          "criteria": [
            "PM2",
            "PP5",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000563290.6",
          "gene_symbol": "SCAPER",
          "hgnc_id": 13081,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD,AR",
          "hgvs_c": "c.3656G>A",
          "hgvs_p": "p.Ser1219Asn"
        }
      ],
      "clinvar_disease": " IDDRP, moderate,Intellectual developmental disorder and retinitis pigmentosa,Intellectual disability,Rod-cone dystrophy",
      "clinvar_classification": "Pathogenic/Likely pathogenic",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Intellectual disability, moderate;Rod-cone dystrophy|Intellectual developmental disorder and retinitis pigmentosa; IDDRP",
      "pathogenicity_classification_combined": "Pathogenic/Likely pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}