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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-78542191-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=78542191&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 78542191,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_002789.6",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "NM_002789.6",
"protein_id": "NP_002780.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000044462.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002789.6"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000044462.12",
"protein_id": "ENSP00000044462.7",
"transcript_support_level": 1,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002789.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000044462.12"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.-33C>T",
"hgvs_p": null,
"transcript": "ENST00000413382.6",
"protein_id": "ENSP00000402118.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 190,
"cds_start": null,
"cds_end": null,
"cds_length": 573,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000413382.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "n.368C>T",
"hgvs_p": null,
"transcript": "ENST00000558635.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000558635.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "n.1748C>T",
"hgvs_p": null,
"transcript": "ENST00000559934.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000559934.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "n.390C>T",
"hgvs_p": null,
"transcript": "ENST00000560842.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000560842.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "NM_001102667.2",
"protein_id": "NP_001096137.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001102667.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "NM_001330676.2",
"protein_id": "NP_001317605.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001330676.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000559082.5",
"protein_id": "ENSP00000453887.1",
"transcript_support_level": 5,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000559082.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000859802.1",
"protein_id": "ENSP00000529861.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859802.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000859804.1",
"protein_id": "ENSP00000529863.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859804.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000859805.1",
"protein_id": "ENSP00000529864.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859805.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000859809.1",
"protein_id": "ENSP00000529868.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 261,
"cds_start": 18,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859809.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000920050.1",
"protein_id": "ENSP00000590109.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 256,
"cds_start": 18,
"cds_end": null,
"cds_length": 771,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920050.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000560737.5",
"protein_id": "ENSP00000453080.1",
"transcript_support_level": 5,
"aa_start": 6,
"aa_end": null,
"aa_length": 235,
"cds_start": 18,
"cds_end": null,
"cds_length": 710,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000560737.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000859807.1",
"protein_id": "ENSP00000529866.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 235,
"cds_start": 18,
"cds_end": null,
"cds_length": 708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859807.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000920051.1",
"protein_id": "ENSP00000590110.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 235,
"cds_start": 18,
"cds_end": null,
"cds_length": 708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920051.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "NM_001330675.2",
"protein_id": "NP_001317604.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 230,
"cds_start": 18,
"cds_end": null,
"cds_length": 693,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001330675.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000560217.5",
"protein_id": "ENSP00000453829.1",
"transcript_support_level": 5,
"aa_start": 6,
"aa_end": null,
"aa_length": 230,
"cds_start": 18,
"cds_end": null,
"cds_length": 693,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000560217.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000859803.1",
"protein_id": "ENSP00000529862.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 230,
"cds_start": 18,
"cds_end": null,
"cds_length": 693,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859803.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000859808.1",
"protein_id": "ENSP00000529867.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 230,
"cds_start": 18,
"cds_end": null,
"cds_length": 693,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859808.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PSMA4",
"gene_hgnc_id": 9533,
"hgvs_c": "c.18C>T",
"hgvs_p": "p.Asp6Asp",
"transcript": "ENST00000920052.1",
"protein_id": "ENSP00000590111.1",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 230,
"cds_start": 18,
"cds_end": null,
"cds_length": 693,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920052.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
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}