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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-78931505-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=78931505&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 78931505,
"ref": "G",
"alt": "A",
"effect": "missense_variant,splice_region_variant",
"transcript": "NM_004390.5",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.494C>T",
"hgvs_p": "p.Ala165Val",
"transcript": "NM_004390.5",
"protein_id": "NP_004381.2",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 335,
"cds_start": 494,
"cds_end": null,
"cds_length": 1008,
"cdna_start": 559,
"cdna_end": null,
"cdna_length": 2145,
"mane_select": "ENST00000220166.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.494C>T",
"hgvs_p": "p.Ala165Val",
"transcript": "ENST00000220166.10",
"protein_id": "ENSP00000220166.6",
"transcript_support_level": 1,
"aa_start": 165,
"aa_end": null,
"aa_length": 335,
"cds_start": 494,
"cds_end": null,
"cds_length": 1008,
"cdna_start": 559,
"cdna_end": null,
"cdna_length": 2145,
"mane_select": "NM_004390.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.494C>T",
"hgvs_p": "p.Ala165Val",
"transcript": "ENST00000615999.5",
"protein_id": "ENSP00000483303.2",
"transcript_support_level": 1,
"aa_start": 165,
"aa_end": null,
"aa_length": 358,
"cds_start": 494,
"cds_end": null,
"cds_length": 1077,
"cdna_start": 498,
"cdna_end": null,
"cdna_length": 1286,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "n.542C>T",
"hgvs_p": null,
"transcript": "ENST00000527715.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "n.*978C>T",
"hgvs_p": null,
"transcript": "ENST00000533777.5",
"protein_id": "ENSP00000431879.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2101,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "n.*978C>T",
"hgvs_p": null,
"transcript": "ENST00000533777.5",
"protein_id": "ENSP00000431879.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2101,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.92C>T",
"hgvs_p": "p.Ala31Val",
"transcript": "NM_001319137.2",
"protein_id": "NP_001306066.1",
"transcript_support_level": null,
"aa_start": 31,
"aa_end": null,
"aa_length": 201,
"cds_start": 92,
"cds_end": null,
"cds_length": 606,
"cdna_start": 1232,
"cdna_end": null,
"cdna_length": 2818,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.827C>T",
"hgvs_p": "p.Ala276Val",
"transcript": "ENST00000677534.1",
"protein_id": "ENSP00000503261.1",
"transcript_support_level": null,
"aa_start": 276,
"aa_end": null,
"aa_length": 446,
"cds_start": 827,
"cds_end": null,
"cds_length": 1341,
"cdna_start": 892,
"cdna_end": null,
"cdna_length": 1760,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.590C>T",
"hgvs_p": "p.Ala197Val",
"transcript": "ENST00000676880.1",
"protein_id": "ENSP00000504341.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 367,
"cds_start": 590,
"cds_end": null,
"cds_length": 1104,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 1513,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.494C>T",
"hgvs_p": "p.Ala165Val",
"transcript": "ENST00000677936.1",
"protein_id": "ENSP00000502988.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 311,
"cds_start": 494,
"cds_end": null,
"cds_length": 936,
"cdna_start": 548,
"cdna_end": null,
"cdna_length": 2127,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.407C>T",
"hgvs_p": "p.Ala136Val",
"transcript": "ENST00000677789.1",
"protein_id": "ENSP00000503073.1",
"transcript_support_level": null,
"aa_start": 136,
"aa_end": null,
"aa_length": 306,
"cds_start": 407,
"cds_end": null,
"cds_length": 921,
"cdna_start": 444,
"cdna_end": null,
"cdna_length": 1198,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.380C>T",
"hgvs_p": "p.Ala127Val",
"transcript": "NM_001411095.1",
"protein_id": "NP_001398024.1",
"transcript_support_level": null,
"aa_start": 127,
"aa_end": null,
"aa_length": 297,
"cds_start": 380,
"cds_end": null,
"cds_length": 894,
"cdna_start": 672,
"cdna_end": null,
"cdna_length": 2258,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.380C>T",
"hgvs_p": "p.Ala127Val",
"transcript": "ENST00000528741.6",
"protein_id": "ENSP00000435329.2",
"transcript_support_level": 5,
"aa_start": 127,
"aa_end": null,
"aa_length": 297,
"cds_start": 380,
"cds_end": null,
"cds_length": 894,
"cdna_start": 471,
"cdna_end": null,
"cdna_length": 1341,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.380C>T",
"hgvs_p": "p.Ala127Val",
"transcript": "ENST00000677316.1",
"protein_id": "ENSP00000504051.1",
"transcript_support_level": null,
"aa_start": 127,
"aa_end": null,
"aa_length": 297,
"cds_start": 380,
"cds_end": null,
"cds_length": 894,
"cdna_start": 665,
"cdna_end": null,
"cdna_length": 1540,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.494C>T",
"hgvs_p": "p.Ala165Val",
"transcript": "ENST00000677810.1",
"protein_id": "ENSP00000503585.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 293,
"cds_start": 494,
"cds_end": null,
"cds_length": 882,
"cdna_start": 559,
"cdna_end": null,
"cdna_length": 2019,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.266C>T",
"hgvs_p": "p.Ala89Val",
"transcript": "ENST00000677011.1",
"protein_id": "ENSP00000504778.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 259,
"cds_start": 266,
"cds_end": null,
"cds_length": 780,
"cdna_start": 583,
"cdna_end": null,
"cdna_length": 2169,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.266C>T",
"hgvs_p": "p.Ala89Val",
"transcript": "ENST00000678644.1",
"protein_id": "ENSP00000503269.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 259,
"cds_start": 266,
"cds_end": null,
"cds_length": 780,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 1601,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.242C>T",
"hgvs_p": "p.Ala81Val",
"transcript": "ENST00000677207.1",
"protein_id": "ENSP00000504828.1",
"transcript_support_level": null,
"aa_start": 81,
"aa_end": null,
"aa_length": 251,
"cds_start": 242,
"cds_end": null,
"cds_length": 756,
"cdna_start": 464,
"cdna_end": null,
"cdna_length": 1339,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "c.440C>T",
"hgvs_p": "p.Ala147Val",
"transcript": "XM_017021951.2",
"protein_id": "XP_016877440.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 317,
"cds_start": 440,
"cds_end": null,
"cds_length": 954,
"cdna_start": 697,
"cdna_end": null,
"cdna_length": 2283,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "n.*372C>T",
"hgvs_p": null,
"transcript": "ENST00000525807.6",
"protein_id": "ENSP00000432935.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1386,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "n.1026C>T",
"hgvs_p": null,
"transcript": "ENST00000527138.6",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5163,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSH",
"gene_hgnc_id": 2535,
"hgvs_c": "n.*154C>T",
"hgvs_p": null,
"transcript": "ENST00000528191.6",
"protein_id": "ENSP00000503084.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1458,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
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