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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-81304249-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=81304249&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 81304249,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_001352686.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3420+599T>G",
"hgvs_p": null,
"transcript": "NM_172217.5",
"protein_id": "NP_757366.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1332,
"cds_start": null,
"cds_end": null,
"cds_length": 3999,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000683961.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_172217.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3420+599T>G",
"hgvs_p": null,
"transcript": "ENST00000683961.1",
"protein_id": "ENSP00000508085.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1332,
"cds_start": null,
"cds_end": null,
"cds_length": 3999,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_172217.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683961.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3561+599T>G",
"hgvs_p": null,
"transcript": "ENST00000302987.10",
"protein_id": "ENSP00000302935.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1378,
"cds_start": null,
"cds_end": null,
"cds_length": 4137,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000302987.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.1317+599T>G",
"hgvs_p": null,
"transcript": "ENST00000394652.6",
"protein_id": "ENSP00000378147.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 631,
"cds_start": null,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394652.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "n.*1399+599T>G",
"hgvs_p": null,
"transcript": "ENST00000558857.5",
"protein_id": "ENSP00000453131.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000558857.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3573+599T>G",
"hgvs_p": null,
"transcript": "NM_001352686.2",
"protein_id": "NP_001339615.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1382,
"cds_start": null,
"cds_end": null,
"cds_length": 4149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001352686.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3561+599T>G",
"hgvs_p": null,
"transcript": "NM_001438661.1",
"protein_id": "NP_001425590.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1379,
"cds_start": null,
"cds_end": null,
"cds_length": 4140,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438661.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3420+599T>G",
"hgvs_p": null,
"transcript": "ENST00000909975.1",
"protein_id": "ENSP00000580034.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1332,
"cds_start": null,
"cds_end": null,
"cds_length": 3999,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909975.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3420+599T>G",
"hgvs_p": null,
"transcript": "NM_001172128.2",
"protein_id": "NP_001165599.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1331,
"cds_start": null,
"cds_end": null,
"cds_length": 3996,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001172128.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3420+599T>G",
"hgvs_p": null,
"transcript": "ENST00000394660.6",
"protein_id": "ENSP00000378155.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 1331,
"cds_start": null,
"cds_end": null,
"cds_length": 3996,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394660.6"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 16,
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"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3420+599T>G",
"hgvs_p": null,
"transcript": "ENST00000706926.1",
"protein_id": "ENSP00000516648.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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},
{
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"canonical": false,
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"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
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"gene_symbol": "IL16",
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"hgvs_c": "c.3168+599T>G",
"hgvs_p": null,
"transcript": "ENST00000909976.1",
"protein_id": "ENSP00000580035.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000909976.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 17,
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"gene_symbol": "IL16",
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"hgvs_c": "c.2910+599T>G",
"hgvs_p": null,
"transcript": "NM_001352685.2",
"protein_id": "NP_001339614.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1161,
"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "NM_001352685.2"
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "IL16",
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"hgvs_c": "c.1590+599T>G",
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"transcript": "NM_001352684.2",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.1317+599T>G",
"hgvs_p": null,
"transcript": "NM_004513.6",
"protein_id": "NP_004504.3",
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004513.6"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 3,
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"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.1329+599T>G",
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"transcript": "ENST00000558332.3",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3612+599T>G",
"hgvs_p": null,
"transcript": "XM_047432447.1",
"protein_id": "XP_047288403.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3612+599T>G",
"hgvs_p": null,
"transcript": "XM_047432448.1",
"protein_id": "XP_047288404.1",
"transcript_support_level": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "IL16",
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"hgvs_c": "c.3561+599T>G",
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},
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],
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"intron_rank": 17,
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"gene_symbol": "IL16",
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"hgvs_c": "c.3612+599T>G",
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},
{
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"strand": true,
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],
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"gene_symbol": "IL16",
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"hgvs_c": "c.3612+599T>G",
"hgvs_p": null,
"transcript": "XM_047432452.1",
"protein_id": "XP_047288408.1",
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"biotype": "protein_coding",
"feature": "XM_047432452.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "IL16",
"gene_hgnc_id": 5980,
"hgvs_c": "c.3420+599T>G",
"hgvs_p": null,
"transcript": "XM_047432453.1",
"protein_id": "XP_047288409.1",
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047432453.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
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],
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}