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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-82683530-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=82683530&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 82683530,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000535359.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.361-1950T>G",
"hgvs_p": null,
"transcript": "NM_001278512.2",
"protein_id": "NP_001265441.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1101,
"cds_start": -4,
"cds_end": null,
"cds_length": 3306,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3754,
"mane_select": "ENST00000535359.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.361-1950T>G",
"hgvs_p": null,
"transcript": "ENST00000535359.6",
"protein_id": "ENSP00000440984.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1101,
"cds_start": -4,
"cds_end": null,
"cds_length": 3306,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3754,
"mane_select": "NM_001278512.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.361-1950T>G",
"hgvs_p": null,
"transcript": "ENST00000261722.8",
"protein_id": "ENSP00000261722.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1088,
"cds_start": -4,
"cds_end": null,
"cds_length": 3267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3738,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.265-1950T>G",
"hgvs_p": null,
"transcript": "ENST00000535348.5",
"protein_id": "ENSP00000438721.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1050,
"cds_start": -4,
"cds_end": null,
"cds_length": 3153,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3254,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "n.507-1950T>G",
"hgvs_p": null,
"transcript": "ENST00000537735.2",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "CPEB1-AS1",
"gene_hgnc_id": 27523,
"hgvs_c": "n.1329-8481A>C",
"hgvs_p": null,
"transcript": "ENST00000560650.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2138,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.361-1950T>G",
"hgvs_p": null,
"transcript": "ENST00000652847.1",
"protein_id": "ENSP00000499785.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1130,
"cds_start": -4,
"cds_end": null,
"cds_length": 3393,
"cdna_start": null,
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"cdna_length": 3714,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.490-1950T>G",
"hgvs_p": null,
"transcript": "ENST00000642989.2",
"protein_id": "ENSP00000493485.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1125,
"cds_start": -4,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3683,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.361-1950T>G",
"hgvs_p": null,
"transcript": "NM_004644.5",
"protein_id": "NP_004635.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1082,
"cds_start": -4,
"cds_end": null,
"cds_length": 3249,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3697,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": 4,
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"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.361-1950T>G",
"hgvs_p": null,
"transcript": "ENST00000668990.2",
"protein_id": "ENSP00000499235.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 3,
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"gene_symbol": "AP3B2",
"gene_hgnc_id": 567,
"hgvs_c": "c.265-1950T>G",
"hgvs_p": null,
"transcript": "NM_001278511.2",
"protein_id": "NP_001265440.1",
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},
{
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"protein_coding": true,
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"consequences": [
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],
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"exon_count": 24,
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"gene_symbol": "AP3B2",
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},
{
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],
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},
{
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],
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"gene_symbol": "AP3B2",
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],
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},
{
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],
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},
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],
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"hgvs_c": "n.564-1950T>G",
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"transcript": "ENST00000543938.6",
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},
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],
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"intron_rank": 5,
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"gene_symbol": "AP3B2",
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"hgvs_c": "n.438-1950T>G",
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],
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],
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"intron_rank": 4,
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"gene_symbol": "AP3B2",
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"transcript": "ENST00000668385.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 4,
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"gene_symbol": "AP3B2",
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"hgvs_c": "n.300-1950T>G",
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}