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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 15-82759503-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=15&pos=82759503&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "15",
"pos": 82759503,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001007122.4",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2095A>G",
"hgvs_p": "p.Lys699Glu",
"transcript": "NM_001007122.4",
"protein_id": "NP_001007123.1",
"transcript_support_level": null,
"aa_start": 699,
"aa_end": null,
"aa_length": 749,
"cds_start": 2095,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000334574.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001007122.4"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2095A>G",
"hgvs_p": "p.Lys699Glu",
"transcript": "ENST00000334574.12",
"protein_id": "ENSP00000335651.8",
"transcript_support_level": 1,
"aa_start": 699,
"aa_end": null,
"aa_length": 749,
"cds_start": 2095,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001007122.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000334574.12"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1960A>G",
"hgvs_p": "p.Lys654Glu",
"transcript": "ENST00000541889.1",
"protein_id": "ENSP00000444078.1",
"transcript_support_level": 1,
"aa_start": 654,
"aa_end": null,
"aa_length": 704,
"cds_start": 1960,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000541889.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2095A>G",
"hgvs_p": "p.Lys699Glu",
"transcript": "ENST00000961201.1",
"protein_id": "ENSP00000631260.1",
"transcript_support_level": null,
"aa_start": 699,
"aa_end": null,
"aa_length": 749,
"cds_start": 2095,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961201.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2065A>G",
"hgvs_p": "p.Lys689Glu",
"transcript": "ENST00000961199.1",
"protein_id": "ENSP00000631258.1",
"transcript_support_level": null,
"aa_start": 689,
"aa_end": null,
"aa_length": 739,
"cds_start": 2065,
"cds_end": null,
"cds_length": 2220,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961199.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2053A>G",
"hgvs_p": "p.Lys685Glu",
"transcript": "ENST00000961203.1",
"protein_id": "ENSP00000631262.1",
"transcript_support_level": null,
"aa_start": 685,
"aa_end": null,
"aa_length": 735,
"cds_start": 2053,
"cds_end": null,
"cds_length": 2208,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961203.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1978A>G",
"hgvs_p": "p.Lys660Glu",
"transcript": "ENST00000961204.1",
"protein_id": "ENSP00000631263.1",
"transcript_support_level": null,
"aa_start": 660,
"aa_end": null,
"aa_length": 710,
"cds_start": 1978,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961204.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1972A>G",
"hgvs_p": "p.Lys658Glu",
"transcript": "ENST00000961202.1",
"protein_id": "ENSP00000631261.1",
"transcript_support_level": null,
"aa_start": 658,
"aa_end": null,
"aa_length": 708,
"cds_start": 1972,
"cds_end": null,
"cds_length": 2127,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961202.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1960A>G",
"hgvs_p": "p.Lys654Glu",
"transcript": "NM_001281805.2",
"protein_id": "NP_001268734.1",
"transcript_support_level": null,
"aa_start": 654,
"aa_end": null,
"aa_length": 704,
"cds_start": 1960,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001281805.2"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1960A>G",
"hgvs_p": "p.Lys654Glu",
"transcript": "NM_001281806.2",
"protein_id": "NP_001268735.1",
"transcript_support_level": null,
"aa_start": 654,
"aa_end": null,
"aa_length": 704,
"cds_start": 1960,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001281806.2"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1960A>G",
"hgvs_p": "p.Lys654Glu",
"transcript": "ENST00000961200.1",
"protein_id": "ENSP00000631259.1",
"transcript_support_level": null,
"aa_start": 654,
"aa_end": null,
"aa_length": 704,
"cds_start": 1960,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961200.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1930A>G",
"hgvs_p": "p.Lys644Glu",
"transcript": "ENST00000961205.1",
"protein_id": "ENSP00000631264.1",
"transcript_support_level": null,
"aa_start": 644,
"aa_end": null,
"aa_length": 694,
"cds_start": 1930,
"cds_end": null,
"cds_length": 2085,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961205.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1864A>G",
"hgvs_p": "p.Lys622Glu",
"transcript": "ENST00000878624.1",
"protein_id": "ENSP00000548683.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 672,
"cds_start": 1864,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878624.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1804A>G",
"hgvs_p": "p.Lys602Glu",
"transcript": "ENST00000878625.1",
"protein_id": "ENSP00000548684.1",
"transcript_support_level": null,
"aa_start": 602,
"aa_end": null,
"aa_length": 652,
"cds_start": 1804,
"cds_end": null,
"cds_length": 1959,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878625.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1729A>G",
"hgvs_p": "p.Lys577Glu",
"transcript": "ENST00000878626.1",
"protein_id": "ENSP00000548685.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 627,
"cds_start": 1729,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878626.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1675A>G",
"hgvs_p": "p.Lys559Glu",
"transcript": "ENST00000961198.1",
"protein_id": "ENSP00000631257.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
"aa_length": 609,
"cds_start": 1675,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961198.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1573A>G",
"hgvs_p": "p.Lys525Glu",
"transcript": "ENST00000878627.1",
"protein_id": "ENSP00000548686.1",
"transcript_support_level": null,
"aa_start": 525,
"aa_end": null,
"aa_length": 575,
"cds_start": 1573,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878627.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1444A>G",
"hgvs_p": "p.Lys482Glu",
"transcript": "ENST00000961206.1",
"protein_id": "ENSP00000631265.1",
"transcript_support_level": null,
"aa_start": 482,
"aa_end": null,
"aa_length": 532,
"cds_start": 1444,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961206.1"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2095A>G",
"hgvs_p": "p.Lys699Glu",
"transcript": "XM_005272425.6",
"protein_id": "XP_005272482.1",
"transcript_support_level": null,
"aa_start": 699,
"aa_end": null,
"aa_length": 749,
"cds_start": 2095,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005272425.6"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2095A>G",
"hgvs_p": "p.Lys699Glu",
"transcript": "XM_024449844.2",
"protein_id": "XP_024305612.1",
"transcript_support_level": null,
"aa_start": 699,
"aa_end": null,
"aa_length": 749,
"cds_start": 2095,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024449844.2"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.2095A>G",
"hgvs_p": "p.Lys699Glu",
"transcript": "XM_024449845.2",
"protein_id": "XP_024305613.1",
"transcript_support_level": null,
"aa_start": 699,
"aa_end": null,
"aa_length": 749,
"cds_start": 2095,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024449845.2"
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"hgvs_c": "c.1864A>G",
"hgvs_p": "p.Lys622Glu",
"transcript": "XM_011521235.4",
"protein_id": "XP_011519537.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 672,
"cds_start": 1864,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011521235.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SNHG21",
"gene_hgnc_id": 50284,
"hgvs_c": "n.434+4719T>C",
"hgvs_p": null,
"transcript": "ENST00000834480.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000834480.1"
}
],
"gene_symbol": "FSD2",
"gene_hgnc_id": 18024,
"dbsnp": "rs760080782",
"frequency_reference_population": 0.000064497726,
"hom_count_reference_population": 0,
"allele_count_reference_population": 104,
"gnomad_exomes_af": 0.0000684818,
"gnomad_genomes_af": 0.0000262781,
"gnomad_exomes_ac": 100,
"gnomad_genomes_ac": 4,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.18031737208366394,
"computational_prediction_selected": "Benign",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.193,
"revel_prediction": "Benign",
"alphamissense_score": 0.2027,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.19,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 4.459,
"phylop100way_prediction": "Uncertain_significance",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": 0,
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,BP4_Moderate",
"acmg_by_gene": [
{
"score": 0,
"benign_score": 2,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "NM_001007122.4",
"gene_symbol": "FSD2",
"hgnc_id": 18024,
"effects": [
"missense_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.2095A>G",
"hgvs_p": "p.Lys699Glu"
},
{
"score": 0,
"benign_score": 2,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "ENST00000834480.1",
"gene_symbol": "SNHG21",
"hgnc_id": 50284,
"effects": [
"intron_variant"
],
"inheritance_mode": "",
"hgvs_c": "n.434+4719T>C",
"hgvs_p": null
}
],
"clinvar_disease": "not specified",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}