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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-11891126-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=11891126&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 11891126,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_002094.4",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.712A>G",
"hgvs_p": "p.Met238Val",
"transcript": "NM_002094.4",
"protein_id": "NP_002085.3",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 637,
"cds_start": 712,
"cds_end": null,
"cds_length": 1914,
"cdna_start": 948,
"cdna_end": null,
"cdna_length": 7141,
"mane_select": "ENST00000434724.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002094.4"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.712A>G",
"hgvs_p": "p.Met238Val",
"transcript": "ENST00000434724.7",
"protein_id": "ENSP00000398131.2",
"transcript_support_level": 1,
"aa_start": 238,
"aa_end": null,
"aa_length": 637,
"cds_start": 712,
"cds_end": null,
"cds_length": 1914,
"cdna_start": 948,
"cdna_end": null,
"cdna_length": 7141,
"mane_select": "NM_002094.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000434724.7"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.709A>G",
"hgvs_p": "p.Met237Val",
"transcript": "ENST00000439887.6",
"protein_id": "ENSP00000408399.2",
"transcript_support_level": 1,
"aa_start": 237,
"aa_end": null,
"aa_length": 636,
"cds_start": 709,
"cds_end": null,
"cds_length": 1911,
"cdna_start": 867,
"cdna_end": null,
"cdna_length": 2509,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000439887.6"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.298A>G",
"hgvs_p": "p.Met100Val",
"transcript": "ENST00000420576.6",
"protein_id": "ENSP00000399539.2",
"transcript_support_level": 1,
"aa_start": 100,
"aa_end": null,
"aa_length": 499,
"cds_start": 298,
"cds_end": null,
"cds_length": 1500,
"cdna_start": 401,
"cdna_end": null,
"cdna_length": 1603,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000420576.6"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.712A>G",
"hgvs_p": "p.Met238Val",
"transcript": "ENST00000895134.1",
"protein_id": "ENSP00000565193.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 643,
"cds_start": 712,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 909,
"cdna_end": null,
"cdna_length": 2703,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895134.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.709A>G",
"hgvs_p": "p.Met237Val",
"transcript": "NM_001130006.2",
"protein_id": "NP_001123478.2",
"transcript_support_level": null,
"aa_start": 237,
"aa_end": null,
"aa_length": 636,
"cds_start": 709,
"cds_end": null,
"cds_length": 1911,
"cdna_start": 945,
"cdna_end": null,
"cdna_length": 7138,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001130006.2"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.712A>G",
"hgvs_p": "p.Met238Val",
"transcript": "ENST00000895137.1",
"protein_id": "ENSP00000565196.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 635,
"cds_start": 712,
"cds_end": null,
"cds_length": 1908,
"cdna_start": 944,
"cdna_end": null,
"cdna_length": 2590,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895137.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.670A>G",
"hgvs_p": "p.Met224Val",
"transcript": "ENST00000913281.1",
"protein_id": "ENSP00000583340.1",
"transcript_support_level": null,
"aa_start": 224,
"aa_end": null,
"aa_length": 623,
"cds_start": 670,
"cds_end": null,
"cds_length": 1872,
"cdna_start": 905,
"cdna_end": null,
"cdna_length": 7098,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913281.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.667A>G",
"hgvs_p": "p.Met223Val",
"transcript": "ENST00000895140.1",
"protein_id": "ENSP00000565199.1",
"transcript_support_level": null,
"aa_start": 223,
"aa_end": null,
"aa_length": 622,
"cds_start": 667,
"cds_end": null,
"cds_length": 1869,
"cdna_start": 864,
"cdna_end": null,
"cdna_length": 2506,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895140.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.664A>G",
"hgvs_p": "p.Met222Val",
"transcript": "ENST00000945601.1",
"protein_id": "ENSP00000615660.1",
"transcript_support_level": null,
"aa_start": 222,
"aa_end": null,
"aa_length": 621,
"cds_start": 664,
"cds_end": null,
"cds_length": 1866,
"cdna_start": 848,
"cdna_end": null,
"cdna_length": 2484,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945601.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.661A>G",
"hgvs_p": "p.Met221Val",
"transcript": "ENST00000945600.1",
"protein_id": "ENSP00000615659.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 620,
"cds_start": 661,
"cds_end": null,
"cds_length": 1863,
"cdna_start": 714,
"cdna_end": null,
"cdna_length": 2824,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945600.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.712A>G",
"hgvs_p": "p.Met238Val",
"transcript": "ENST00000913280.1",
"protein_id": "ENSP00000583339.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 610,
"cds_start": 712,
"cds_end": null,
"cds_length": 1833,
"cdna_start": 970,
"cdna_end": null,
"cdna_length": 7082,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913280.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.628A>G",
"hgvs_p": "p.Met210Val",
"transcript": "ENST00000895138.1",
"protein_id": "ENSP00000565197.1",
"transcript_support_level": null,
"aa_start": 210,
"aa_end": null,
"aa_length": 609,
"cds_start": 628,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 856,
"cdna_end": null,
"cdna_length": 2502,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895138.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.709A>G",
"hgvs_p": "p.Met237Val",
"transcript": "ENST00000913283.1",
"protein_id": "ENSP00000583342.1",
"transcript_support_level": null,
"aa_start": 237,
"aa_end": null,
"aa_length": 609,
"cds_start": 709,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 941,
"cdna_end": null,
"cdna_length": 2979,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913283.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.625A>G",
"hgvs_p": "p.Met209Val",
"transcript": "ENST00000913284.1",
"protein_id": "ENSP00000583343.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 608,
"cds_start": 625,
"cds_end": null,
"cds_length": 1827,
"cdna_start": 819,
"cdna_end": null,
"cdna_length": 2479,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913284.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.712A>G",
"hgvs_p": "p.Met238Val",
"transcript": "ENST00000895139.1",
"protein_id": "ENSP00000565198.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 607,
"cds_start": 712,
"cds_end": null,
"cds_length": 1824,
"cdna_start": 942,
"cdna_end": null,
"cdna_length": 2491,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895139.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.712A>G",
"hgvs_p": "p.Met238Val",
"transcript": "ENST00000895133.1",
"protein_id": "ENSP00000565192.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 579,
"cds_start": 712,
"cds_end": null,
"cds_length": 1740,
"cdna_start": 948,
"cdna_end": null,
"cdna_length": 2893,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895133.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.484A>G",
"hgvs_p": "p.Met162Val",
"transcript": "ENST00000895136.1",
"protein_id": "ENSP00000565195.1",
"transcript_support_level": null,
"aa_start": 162,
"aa_end": null,
"aa_length": 561,
"cds_start": 484,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 740,
"cdna_end": null,
"cdna_length": 2382,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895136.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.400A>G",
"hgvs_p": "p.Met134Val",
"transcript": "ENST00000895135.1",
"protein_id": "ENSP00000565194.1",
"transcript_support_level": null,
"aa_start": 134,
"aa_end": null,
"aa_length": 533,
"cds_start": 400,
"cds_end": null,
"cds_length": 1602,
"cdna_start": 659,
"cdna_end": null,
"cdna_length": 2317,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895135.1"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.298A>G",
"hgvs_p": "p.Met100Val",
"transcript": "NM_001130007.2",
"protein_id": "NP_001123479.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 499,
"cds_start": 298,
"cds_end": null,
"cds_length": 1500,
"cdna_start": 973,
"cdna_end": null,
"cdna_length": 7166,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001130007.2"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.298A>G",
"hgvs_p": "p.Met100Val",
"transcript": "ENST00000563468.5",
"protein_id": "ENSP00000454351.1",
"transcript_support_level": 2,
"aa_start": 100,
"aa_end": null,
"aa_length": 499,
"cds_start": 298,
"cds_end": null,
"cds_length": 1500,
"cdna_start": 325,
"cdna_end": null,
"cdna_length": 1962,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000563468.5"
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Met105Val",
"transcript": "ENST00000565267.5",
"protein_id": "ENSP00000456057.1",
"transcript_support_level": 5,
"aa_start": 105,
"aa_end": null,
"aa_length": 474,
"cds_start": 313,
"cds_end": null,
"cds_length": 1425,
"cdna_start": 315,
"cdna_end": null,
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"phenotype_combined": "not specified",
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}
],
"message": null
}