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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-11896708-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=11896708&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 11896708,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_002094.4",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "NM_002094.4",
"protein_id": "NP_002085.3",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 637,
"cds_start": 514,
"cds_end": null,
"cds_length": 1914,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000434724.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002094.4"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000434724.7",
"protein_id": "ENSP00000398131.2",
"transcript_support_level": 1,
"aa_start": 172,
"aa_end": null,
"aa_length": 637,
"cds_start": 514,
"cds_end": null,
"cds_length": 1914,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002094.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000434724.7"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.511G>A",
"hgvs_p": "p.Gly171Ser",
"transcript": "ENST00000439887.6",
"protein_id": "ENSP00000408399.2",
"transcript_support_level": 1,
"aa_start": 171,
"aa_end": null,
"aa_length": 636,
"cds_start": 511,
"cds_end": null,
"cds_length": 1911,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000439887.6"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.100G>A",
"hgvs_p": "p.Gly34Ser",
"transcript": "ENST00000420576.6",
"protein_id": "ENSP00000399539.2",
"transcript_support_level": 1,
"aa_start": 34,
"aa_end": null,
"aa_length": 499,
"cds_start": 100,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000420576.6"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000895134.1",
"protein_id": "ENSP00000565193.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 643,
"cds_start": 514,
"cds_end": null,
"cds_length": 1932,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895134.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.511G>A",
"hgvs_p": "p.Gly171Ser",
"transcript": "NM_001130006.2",
"protein_id": "NP_001123478.2",
"transcript_support_level": null,
"aa_start": 171,
"aa_end": null,
"aa_length": 636,
"cds_start": 511,
"cds_end": null,
"cds_length": 1911,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001130006.2"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000895137.1",
"protein_id": "ENSP00000565196.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 635,
"cds_start": 514,
"cds_end": null,
"cds_length": 1908,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895137.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000913282.1",
"protein_id": "ENSP00000583341.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 628,
"cds_start": 514,
"cds_end": null,
"cds_length": 1887,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913282.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.472G>A",
"hgvs_p": "p.Gly158Ser",
"transcript": "ENST00000913281.1",
"protein_id": "ENSP00000583340.1",
"transcript_support_level": null,
"aa_start": 158,
"aa_end": null,
"aa_length": 623,
"cds_start": 472,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913281.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.469G>A",
"hgvs_p": "p.Gly157Ser",
"transcript": "ENST00000895140.1",
"protein_id": "ENSP00000565199.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 622,
"cds_start": 469,
"cds_end": null,
"cds_length": 1869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895140.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000945601.1",
"protein_id": "ENSP00000615660.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 621,
"cds_start": 514,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945601.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.511G>A",
"hgvs_p": "p.Gly171Ser",
"transcript": "ENST00000945600.1",
"protein_id": "ENSP00000615659.1",
"transcript_support_level": null,
"aa_start": 171,
"aa_end": null,
"aa_length": 620,
"cds_start": 511,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945600.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000913280.1",
"protein_id": "ENSP00000583339.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 610,
"cds_start": 514,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913280.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.430G>A",
"hgvs_p": "p.Gly144Ser",
"transcript": "ENST00000895138.1",
"protein_id": "ENSP00000565197.1",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 609,
"cds_start": 430,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895138.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.511G>A",
"hgvs_p": "p.Gly171Ser",
"transcript": "ENST00000913283.1",
"protein_id": "ENSP00000583342.1",
"transcript_support_level": null,
"aa_start": 171,
"aa_end": null,
"aa_length": 609,
"cds_start": 511,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913283.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.427G>A",
"hgvs_p": "p.Gly143Ser",
"transcript": "ENST00000913284.1",
"protein_id": "ENSP00000583343.1",
"transcript_support_level": null,
"aa_start": 143,
"aa_end": null,
"aa_length": 608,
"cds_start": 427,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913284.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000895139.1",
"protein_id": "ENSP00000565198.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 607,
"cds_start": 514,
"cds_end": null,
"cds_length": 1824,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895139.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.514G>A",
"hgvs_p": "p.Gly172Ser",
"transcript": "ENST00000895133.1",
"protein_id": "ENSP00000565192.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 579,
"cds_start": 514,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895133.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.100G>A",
"hgvs_p": "p.Gly34Ser",
"transcript": "NM_001130007.2",
"protein_id": "NP_001123479.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 499,
"cds_start": 100,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001130007.2"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.100G>A",
"hgvs_p": "p.Gly34Ser",
"transcript": "ENST00000563468.5",
"protein_id": "ENSP00000454351.1",
"transcript_support_level": 2,
"aa_start": 34,
"aa_end": null,
"aa_length": 499,
"cds_start": 100,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000563468.5"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.115G>A",
"hgvs_p": "p.Gly39Ser",
"transcript": "ENST00000565267.5",
"protein_id": "ENSP00000456057.1",
"transcript_support_level": 5,
"aa_start": 39,
"aa_end": null,
"aa_length": 474,
"cds_start": 115,
"cds_end": null,
"cds_length": 1425,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000565267.5"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GSPT1",
"gene_hgnc_id": 4621,
"hgvs_c": "c.193G>A",
"hgvs_p": "p.Gly65Ser",
"transcript": "ENST00000568849.5",
"protein_id": "ENSP00000456897.1",
"transcript_support_level": 3,
"aa_start": 65,
"aa_end": null,
"aa_length": 198,
"cds_start": 193,
"cds_end": null,
"cds_length": 599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000568849.5"
},
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}
],
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}