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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-1351972-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=1351972&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 1351972,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_032520.5",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "NM_032520.5",
"protein_id": "NP_115909.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 305,
"cds_start": 7,
"cds_end": null,
"cds_length": 918,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000204679.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032520.5"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000204679.9",
"protein_id": "ENSP00000204679.4",
"transcript_support_level": 1,
"aa_start": 3,
"aa_end": null,
"aa_length": 305,
"cds_start": 7,
"cds_end": null,
"cds_length": 918,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032520.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000204679.9"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891792.1",
"protein_id": "ENSP00000561851.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 345,
"cds_start": 7,
"cds_end": null,
"cds_length": 1038,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891792.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000529110.2",
"protein_id": "ENSP00000435349.2",
"transcript_support_level": 2,
"aa_start": 3,
"aa_end": null,
"aa_length": 333,
"cds_start": 7,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000529110.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891785.1",
"protein_id": "ENSP00000561844.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 324,
"cds_start": 7,
"cds_end": null,
"cds_length": 975,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891785.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000683887.1",
"protein_id": "ENSP00000506886.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 321,
"cds_start": 7,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683887.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000947151.1",
"protein_id": "ENSP00000617210.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 318,
"cds_start": 7,
"cds_end": null,
"cds_length": 957,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947151.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891787.1",
"protein_id": "ENSP00000561846.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 315,
"cds_start": 7,
"cds_end": null,
"cds_length": 948,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891787.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891793.1",
"protein_id": "ENSP00000561852.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 315,
"cds_start": 7,
"cds_end": null,
"cds_length": 948,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891793.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891789.1",
"protein_id": "ENSP00000561848.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 300,
"cds_start": 7,
"cds_end": null,
"cds_length": 903,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891789.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891784.1",
"protein_id": "ENSP00000561843.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 299,
"cds_start": 7,
"cds_end": null,
"cds_length": 900,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891784.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891786.1",
"protein_id": "ENSP00000561845.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 292,
"cds_start": 7,
"cds_end": null,
"cds_length": 879,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891786.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891788.1",
"protein_id": "ENSP00000561847.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 287,
"cds_start": 7,
"cds_end": null,
"cds_length": 864,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891788.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891790.1",
"protein_id": "ENSP00000561849.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 277,
"cds_start": 7,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891790.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000891791.1",
"protein_id": "ENSP00000561850.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 263,
"cds_start": 7,
"cds_end": null,
"cds_length": 792,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891791.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000928980.1",
"protein_id": "ENSP00000599039.1",
"transcript_support_level": null,
"aa_start": 3,
"aa_end": null,
"aa_length": 239,
"cds_start": 7,
"cds_end": null,
"cds_length": 720,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928980.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "c.7G>T",
"hgvs_p": "p.Ala3Ser",
"transcript": "ENST00000527137.2",
"protein_id": "ENSP00000480060.1",
"transcript_support_level": 2,
"aa_start": 3,
"aa_end": null,
"aa_length": 61,
"cds_start": 7,
"cds_end": null,
"cds_length": 186,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000527137.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "n.7G>T",
"hgvs_p": null,
"transcript": "ENST00000526820.5",
"protein_id": "ENSP00000434413.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000526820.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "n.27G>T",
"hgvs_p": null,
"transcript": "ENST00000527168.6",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000527168.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "n.29G>T",
"hgvs_p": null,
"transcript": "ENST00000527876.5",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000527876.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "n.25G>T",
"hgvs_p": null,
"transcript": "ENST00000534197.5",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000534197.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GNPTG",
"gene_hgnc_id": 23026,
"hgvs_c": "n.7G>T",
"hgvs_p": null,
"transcript": "ENST00000683366.1",
"protein_id": "ENSP00000507283.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000683366.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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{
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],
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}
],
"message": null
}