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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-1362526-A-ACCCC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=1362526&ref=A&alt=ACCCC&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "16",
      "pos": 1362526,
      "ref": "A",
      "alt": "ACCCC",
      "effect": "frameshift_variant,splice_region_variant",
      "transcript": "NM_032520.5",
      "consequences": [
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.604_607dupCCCC",
          "hgvs_p": "p.Gln203fs",
          "transcript": "NM_032520.5",
          "protein_id": "NP_115909.1",
          "transcript_support_level": null,
          "aa_start": 203,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": 608,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000204679.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_032520.5"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.604_607dupCCCC",
          "hgvs_p": "p.Gln203fs",
          "transcript": "ENST00000204679.9",
          "protein_id": "ENSP00000204679.4",
          "transcript_support_level": 1,
          "aa_start": 203,
          "aa_end": null,
          "aa_length": 305,
          "cds_start": 608,
          "cds_end": null,
          "cds_length": 918,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_032520.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000204679.9"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.724_727dupCCCC",
          "hgvs_p": "p.Gln243fs",
          "transcript": "ENST00000891792.1",
          "protein_id": "ENSP00000561851.1",
          "transcript_support_level": null,
          "aa_start": 243,
          "aa_end": null,
          "aa_length": 345,
          "cds_start": 728,
          "cds_end": null,
          "cds_length": 1038,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891792.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.688_691dupCCCC",
          "hgvs_p": "p.Gln231fs",
          "transcript": "ENST00000529110.2",
          "protein_id": "ENSP00000435349.2",
          "transcript_support_level": 2,
          "aa_start": 231,
          "aa_end": null,
          "aa_length": 333,
          "cds_start": 692,
          "cds_end": null,
          "cds_length": 1002,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000529110.2"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.661_664dupCCCC",
          "hgvs_p": "p.Gln222fs",
          "transcript": "ENST00000891785.1",
          "protein_id": "ENSP00000561844.1",
          "transcript_support_level": null,
          "aa_start": 222,
          "aa_end": null,
          "aa_length": 324,
          "cds_start": 665,
          "cds_end": null,
          "cds_length": 975,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891785.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.652_655dupCCCC",
          "hgvs_p": "p.Gln219fs",
          "transcript": "ENST00000683887.1",
          "protein_id": "ENSP00000506886.1",
          "transcript_support_level": null,
          "aa_start": 219,
          "aa_end": null,
          "aa_length": 321,
          "cds_start": 656,
          "cds_end": null,
          "cds_length": 966,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000683887.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.643_646dupCCCC",
          "hgvs_p": "p.Gln216fs",
          "transcript": "ENST00000947151.1",
          "protein_id": "ENSP00000617210.1",
          "transcript_support_level": null,
          "aa_start": 216,
          "aa_end": null,
          "aa_length": 318,
          "cds_start": 647,
          "cds_end": null,
          "cds_length": 957,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000947151.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.604_607dupCCCC",
          "hgvs_p": "p.Gln203fs",
          "transcript": "ENST00000891787.1",
          "protein_id": "ENSP00000561846.1",
          "transcript_support_level": null,
          "aa_start": 203,
          "aa_end": null,
          "aa_length": 315,
          "cds_start": 608,
          "cds_end": null,
          "cds_length": 948,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891787.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.634_637dupCCCC",
          "hgvs_p": "p.Gln213fs",
          "transcript": "ENST00000891793.1",
          "protein_id": "ENSP00000561852.1",
          "transcript_support_level": null,
          "aa_start": 213,
          "aa_end": null,
          "aa_length": 315,
          "cds_start": 638,
          "cds_end": null,
          "cds_length": 948,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891793.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.589_592dupCCCC",
          "hgvs_p": "p.Gln198fs",
          "transcript": "ENST00000891789.1",
          "protein_id": "ENSP00000561848.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 300,
          "cds_start": 593,
          "cds_end": null,
          "cds_length": 903,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891789.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.586_589dupCCCC",
          "hgvs_p": "p.Gln197fs",
          "transcript": "ENST00000891784.1",
          "protein_id": "ENSP00000561843.1",
          "transcript_support_level": null,
          "aa_start": 197,
          "aa_end": null,
          "aa_length": 299,
          "cds_start": 590,
          "cds_end": null,
          "cds_length": 900,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891784.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.604_607dupCCCC",
          "hgvs_p": "p.Gln203fs",
          "transcript": "ENST00000891788.1",
          "protein_id": "ENSP00000561847.1",
          "transcript_support_level": null,
          "aa_start": 203,
          "aa_end": null,
          "aa_length": 287,
          "cds_start": 608,
          "cds_end": null,
          "cds_length": 864,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891788.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.520_523dupCCCC",
          "hgvs_p": "p.Gln175fs",
          "transcript": "ENST00000891790.1",
          "protein_id": "ENSP00000561849.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 277,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 834,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891790.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "PP?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.478_481dupCCCC",
          "hgvs_p": "p.Gln161fs",
          "transcript": "ENST00000891791.1",
          "protein_id": "ENSP00000561850.1",
          "transcript_support_level": null,
          "aa_start": 161,
          "aa_end": null,
          "aa_length": 263,
          "cds_start": 482,
          "cds_end": null,
          "cds_length": 792,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891791.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 8,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.570+34_570+37dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000891786.1",
          "protein_id": "ENSP00000561845.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 292,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 879,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000891786.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "c.412-82_412-79dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000928980.1",
          "protein_id": "ENSP00000599039.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 239,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 720,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928980.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.1751_1754dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000527076.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000527076.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.703_706dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000527168.6",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000527168.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.662_665dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000529957.6",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000529957.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.*336_*339dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000683366.1",
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          "cdna_start": null,
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          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000683366.1"
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.598_601dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000684100.1",
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          "transcript_support_level": null,
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          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000684100.1"
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.662_665dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000684126.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000684126.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.1229_1232dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000684688.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000684688.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GNPTG",
          "gene_hgnc_id": 23026,
          "hgvs_c": "n.*336_*339dupCCCC",
          "hgvs_p": null,
          "transcript": "ENST00000683366.1",
          "protein_id": "ENSP00000507283.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000683366.1"
        }
      ],
      "gene_symbol": "GNPTG",
      "gene_hgnc_id": 23026,
      "dbsnp": "rs756225251",
      "frequency_reference_population": 6.840759e-7,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 1,
      "gnomad_exomes_af": 6.84076e-7,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 7.215,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 10,
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PVS1,PM2",
      "acmg_by_gene": [
        {
          "score": 10,
          "benign_score": 0,
          "pathogenic_score": 10,
          "criteria": [
            "PVS1",
            "PM2"
          ],
          "verdict": "Pathogenic",
          "transcript": "NM_032520.5",
          "gene_symbol": "GNPTG",
          "hgnc_id": 23026,
          "effects": [
            "frameshift_variant",
            "splice_region_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.604_607dupCCCC",
          "hgvs_p": "p.Gln203fs"
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}