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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-1507605-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=1507605&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 1507605,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_016111.4",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "NM_016111.4",
"protein_id": "NP_057195.2",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000262319.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_016111.4"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000262319.11",
"protein_id": "ENSP00000262319.6",
"transcript_support_level": 1,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_016111.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000262319.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "n.588G>A",
"hgvs_p": null,
"transcript": "ENST00000568240.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000568240.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2437G>A",
"hgvs_p": "p.Val813Met",
"transcript": "ENST00000889741.1",
"protein_id": "ENSP00000559800.1",
"transcript_support_level": null,
"aa_start": 813,
"aa_end": null,
"aa_length": 884,
"cds_start": 2437,
"cds_end": null,
"cds_length": 2655,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889741.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2437G>A",
"hgvs_p": "p.Val813Met",
"transcript": "ENST00000914530.1",
"protein_id": "ENSP00000584589.1",
"transcript_support_level": null,
"aa_start": 813,
"aa_end": null,
"aa_length": 884,
"cds_start": 2437,
"cds_end": null,
"cds_length": 2655,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914530.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889740.1",
"protein_id": "ENSP00000559799.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 878,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2637,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889740.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889743.1",
"protein_id": "ENSP00000559802.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 878,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2637,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889743.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000962544.1",
"protein_id": "ENSP00000632603.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 878,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2637,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962544.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2326G>A",
"hgvs_p": "p.Val776Met",
"transcript": "ENST00000914534.1",
"protein_id": "ENSP00000584593.1",
"transcript_support_level": null,
"aa_start": 776,
"aa_end": null,
"aa_length": 847,
"cds_start": 2326,
"cds_end": null,
"cds_length": 2544,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914534.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2320G>A",
"hgvs_p": "p.Val774Met",
"transcript": "ENST00000962546.1",
"protein_id": "ENSP00000632605.1",
"transcript_support_level": null,
"aa_start": 774,
"aa_end": null,
"aa_length": 845,
"cds_start": 2320,
"cds_end": null,
"cds_length": 2538,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962546.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2314G>A",
"hgvs_p": "p.Val772Met",
"transcript": "ENST00000962543.1",
"protein_id": "ENSP00000632602.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 843,
"cds_start": 2314,
"cds_end": null,
"cds_length": 2532,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962543.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "NM_001351846.2",
"protein_id": "NP_001338775.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351846.2"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889735.1",
"protein_id": "ENSP00000559794.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889735.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889736.1",
"protein_id": "ENSP00000559795.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889736.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889738.1",
"protein_id": "ENSP00000559797.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889738.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889739.1",
"protein_id": "ENSP00000559798.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889739.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889742.1",
"protein_id": "ENSP00000559801.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889742.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000889744.1",
"protein_id": "ENSP00000559803.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889744.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000914532.1",
"protein_id": "ENSP00000584591.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914532.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000914535.1",
"protein_id": "ENSP00000584594.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914535.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000962545.1",
"protein_id": "ENSP00000632604.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2514,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962545.1"
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TELO2",
"gene_hgnc_id": 29099,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Val766Met",
"transcript": "ENST00000962547.1",
"protein_id": "ENSP00000632606.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 837,
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