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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-15599021-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=15599021&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 15599021,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_014647.4",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4817C>T",
"hgvs_p": "p.Pro1606Leu",
"transcript": "NM_014647.4",
"protein_id": "NP_055462.2",
"transcript_support_level": null,
"aa_start": 1606,
"aa_end": null,
"aa_length": 1742,
"cds_start": 4817,
"cds_end": null,
"cds_length": 5229,
"cdna_start": 5012,
"cdna_end": null,
"cdna_length": 7730,
"mane_select": "ENST00000396368.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4817C>T",
"hgvs_p": "p.Pro1606Leu",
"transcript": "ENST00000396368.8",
"protein_id": "ENSP00000379654.3",
"transcript_support_level": 1,
"aa_start": 1606,
"aa_end": null,
"aa_length": 1742,
"cds_start": 4817,
"cds_end": null,
"cds_length": 5229,
"cdna_start": 5012,
"cdna_end": null,
"cdna_length": 7730,
"mane_select": "NM_014647.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4817C>T",
"hgvs_p": "p.Pro1606Leu",
"transcript": "ENST00000551742.5",
"protein_id": "ENSP00000450309.1",
"transcript_support_level": 1,
"aa_start": 1606,
"aa_end": null,
"aa_length": 1742,
"cds_start": 4817,
"cds_end": null,
"cds_length": 5229,
"cdna_start": 4966,
"cdna_end": null,
"cdna_length": 5900,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4808C>T",
"hgvs_p": "p.Pro1603Leu",
"transcript": "ENST00000548025.5",
"protein_id": "ENSP00000449376.1",
"transcript_support_level": 1,
"aa_start": 1603,
"aa_end": null,
"aa_length": 1739,
"cds_start": 4808,
"cds_end": null,
"cds_length": 5220,
"cdna_start": 4957,
"cdna_end": null,
"cdna_length": 5891,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4817C>T",
"hgvs_p": "p.Pro1606Leu",
"transcript": "NM_001184998.2",
"protein_id": "NP_001171927.1",
"transcript_support_level": null,
"aa_start": 1606,
"aa_end": null,
"aa_length": 1742,
"cds_start": 4817,
"cds_end": null,
"cds_length": 5229,
"cdna_start": 5012,
"cdna_end": null,
"cdna_length": 7730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4808C>T",
"hgvs_p": "p.Pro1603Leu",
"transcript": "NM_001184999.2",
"protein_id": "NP_001171928.1",
"transcript_support_level": null,
"aa_start": 1603,
"aa_end": null,
"aa_length": 1739,
"cds_start": 4808,
"cds_end": null,
"cds_length": 5220,
"cdna_start": 5003,
"cdna_end": null,
"cdna_length": 7721,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4322C>T",
"hgvs_p": "p.Pro1441Leu",
"transcript": "ENST00000540441.6",
"protein_id": "ENSP00000439819.2",
"transcript_support_level": 5,
"aa_start": 1441,
"aa_end": null,
"aa_length": 1577,
"cds_start": 4322,
"cds_end": null,
"cds_length": 4734,
"cdna_start": 4387,
"cdna_end": null,
"cdna_length": 7105,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4820C>T",
"hgvs_p": "p.Pro1607Leu",
"transcript": "XM_005255704.2",
"protein_id": "XP_005255761.1",
"transcript_support_level": null,
"aa_start": 1607,
"aa_end": null,
"aa_length": 1743,
"cds_start": 4820,
"cds_end": null,
"cds_length": 5232,
"cdna_start": 5015,
"cdna_end": null,
"cdna_length": 7733,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4820C>T",
"hgvs_p": "p.Pro1607Leu",
"transcript": "XM_017023900.3",
"protein_id": "XP_016879389.1",
"transcript_support_level": null,
"aa_start": 1607,
"aa_end": null,
"aa_length": 1743,
"cds_start": 4820,
"cds_end": null,
"cds_length": 5232,
"cdna_start": 5042,
"cdna_end": null,
"cdna_length": 7760,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4817C>T",
"hgvs_p": "p.Pro1606Leu",
"transcript": "XM_017023901.3",
"protein_id": "XP_016879390.1",
"transcript_support_level": null,
"aa_start": 1606,
"aa_end": null,
"aa_length": 1742,
"cds_start": 4817,
"cds_end": null,
"cds_length": 5229,
"cdna_start": 5039,
"cdna_end": null,
"cdna_length": 7757,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4817C>T",
"hgvs_p": "p.Pro1606Leu",
"transcript": "XM_047434938.1",
"protein_id": "XP_047290894.1",
"transcript_support_level": null,
"aa_start": 1606,
"aa_end": null,
"aa_length": 1742,
"cds_start": 4817,
"cds_end": null,
"cds_length": 5229,
"cdna_start": 5039,
"cdna_end": null,
"cdna_length": 7757,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4814C>T",
"hgvs_p": "p.Pro1605Leu",
"transcript": "XM_005255706.3",
"protein_id": "XP_005255763.1",
"transcript_support_level": null,
"aa_start": 1605,
"aa_end": null,
"aa_length": 1741,
"cds_start": 4814,
"cds_end": null,
"cds_length": 5226,
"cdna_start": 5009,
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"cdna_length": 7727,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4814C>T",
"hgvs_p": "p.Pro1605Leu",
"transcript": "XM_047434939.1",
"protein_id": "XP_047290895.1",
"transcript_support_level": null,
"aa_start": 1605,
"aa_end": null,
"aa_length": 1741,
"cds_start": 4814,
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"cds_length": 5226,
"cdna_start": 5036,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4790C>T",
"hgvs_p": "p.Pro1597Leu",
"transcript": "XM_005255707.3",
"protein_id": "XP_005255764.1",
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"aa_start": 1597,
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"cds_start": 4790,
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"cdna_start": 4985,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4790C>T",
"hgvs_p": "p.Pro1597Leu",
"transcript": "XM_047434940.1",
"protein_id": "XP_047290896.1",
"transcript_support_level": null,
"aa_start": 1597,
"aa_end": null,
"aa_length": 1733,
"cds_start": 4790,
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"cds_length": 5202,
"cdna_start": 5012,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4787C>T",
"hgvs_p": "p.Pro1596Leu",
"transcript": "XM_047434941.1",
"protein_id": "XP_047290897.1",
"transcript_support_level": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4787C>T",
"hgvs_p": "p.Pro1596Leu",
"transcript": "XM_047434942.1",
"protein_id": "XP_047290898.1",
"transcript_support_level": null,
"aa_start": 1596,
"aa_end": null,
"aa_length": 1732,
"cds_start": 4787,
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"cds_length": 5199,
"cdna_start": 5009,
"cdna_end": null,
"cdna_length": 7727,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4658C>T",
"hgvs_p": "p.Pro1553Leu",
"transcript": "XM_017023902.3",
"protein_id": "XP_016879391.1",
"transcript_support_level": null,
"aa_start": 1553,
"aa_end": null,
"aa_length": 1689,
"cds_start": 4658,
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"cdna_start": 4853,
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"mane_select": null,
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"feature": null
},
{
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"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4655C>T",
"hgvs_p": "p.Pro1552Leu",
"transcript": "XM_047434943.1",
"protein_id": "XP_047290899.1",
"transcript_support_level": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4655C>T",
"hgvs_p": "p.Pro1552Leu",
"transcript": "XM_047434944.1",
"protein_id": "XP_047290900.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
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"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4391C>T",
"hgvs_p": "p.Pro1464Leu",
"transcript": "XM_017023903.3",
"protein_id": "XP_016879392.1",
"transcript_support_level": null,
"aa_start": 1464,
"aa_end": null,
"aa_length": 1600,
"cds_start": 4391,
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"cds_length": 4803,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MARF1",
"gene_hgnc_id": 29562,
"hgvs_c": "c.4388C>T",
"hgvs_p": "p.Pro1463Leu",
"transcript": "XM_017023904.3",
"protein_id": "XP_016879393.1",
"transcript_support_level": null,
"aa_start": 1463,
"aa_end": null,
"aa_length": 1599,
"cds_start": 4388,
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"cdna_start": 4583,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
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"phenotype_combined": "not specified",
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}
],
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}