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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-16079364-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=16079364&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 16079364,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000399410.8",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "NM_004996.4",
"protein_id": "NP_004987.2",
"transcript_support_level": null,
"aa_start": 667,
"aa_end": null,
"aa_length": 1531,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4596,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 6504,
"mane_select": "ENST00000399410.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "ENST00000399410.8",
"protein_id": "ENSP00000382342.3",
"transcript_support_level": 1,
"aa_start": 667,
"aa_end": null,
"aa_length": 1531,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4596,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 6504,
"mane_select": "NM_004996.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "ENST00000572882.3",
"protein_id": "ENSP00000461615.2",
"transcript_support_level": 1,
"aa_start": 667,
"aa_end": null,
"aa_length": 1472,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4419,
"cdna_start": 2176,
"cdna_end": null,
"cdna_length": 6387,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "ENST00000399408.7",
"protein_id": "ENSP00000382340.4",
"transcript_support_level": 5,
"aa_start": 667,
"aa_end": null,
"aa_length": 1541,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4626,
"cdna_start": 2176,
"cdna_end": null,
"cdna_length": 6594,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1875C>T",
"hgvs_p": "p.Ser625Ser",
"transcript": "NM_019901.2",
"protein_id": "NP_063956.2",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 1489,
"cds_start": 1875,
"cds_end": null,
"cds_length": 4470,
"cdna_start": 2011,
"cdna_end": null,
"cdna_length": 6378,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1854C>T",
"hgvs_p": "p.Ser618Ser",
"transcript": "NM_019902.2",
"protein_id": "NP_063957.2",
"transcript_support_level": null,
"aa_start": 618,
"aa_end": null,
"aa_length": 1482,
"cds_start": 1854,
"cds_end": null,
"cds_length": 4449,
"cdna_start": 1990,
"cdna_end": null,
"cdna_length": 6357,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "NM_019898.3",
"protein_id": "NP_063953.2",
"transcript_support_level": null,
"aa_start": 667,
"aa_end": null,
"aa_length": 1475,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4428,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 6336,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "NM_019862.3",
"protein_id": "NP_063915.2",
"transcript_support_level": null,
"aa_start": 667,
"aa_end": null,
"aa_length": 1472,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4419,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 6327,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "NM_001438755.1",
"protein_id": "NP_001425684.1",
"transcript_support_level": null,
"aa_start": 667,
"aa_end": null,
"aa_length": 1466,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4401,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 6309,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1728C>T",
"hgvs_p": "p.Ser576Ser",
"transcript": "NM_001438715.1",
"protein_id": "NP_001425644.1",
"transcript_support_level": null,
"aa_start": 576,
"aa_end": null,
"aa_length": 1440,
"cds_start": 1728,
"cds_end": null,
"cds_length": 4323,
"cdna_start": 1864,
"cdna_end": null,
"cdna_length": 6231,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2001C>T",
"hgvs_p": "p.Ser667Ser",
"transcript": "NM_019899.3",
"protein_id": "NP_063954.2",
"transcript_support_level": null,
"aa_start": 667,
"aa_end": null,
"aa_length": 1416,
"cds_start": 2001,
"cds_end": null,
"cds_length": 4251,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 6159,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1590C>T",
"hgvs_p": "p.Ser530Ser",
"transcript": "NM_001438717.1",
"protein_id": "NP_001425646.1",
"transcript_support_level": null,
"aa_start": 530,
"aa_end": null,
"aa_length": 1394,
"cds_start": 1590,
"cds_end": null,
"cds_length": 4185,
"cdna_start": 1726,
"cdna_end": null,
"cdna_length": 6093,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1716C>T",
"hgvs_p": "p.Ser572Ser",
"transcript": "NM_001438718.1",
"protein_id": "NP_001425647.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 1377,
"cds_start": 1716,
"cds_end": null,
"cds_length": 4134,
"cdna_start": 1852,
"cdna_end": null,
"cdna_length": 6042,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1875C>T",
"hgvs_p": "p.Ser625Ser",
"transcript": "NM_001438719.1",
"protein_id": "NP_001425648.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 1374,
"cds_start": 1875,
"cds_end": null,
"cds_length": 4125,
"cdna_start": 2011,
"cdna_end": null,
"cdna_length": 6033,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1875C>T",
"hgvs_p": "p.Ser625Ser",
"transcript": "ENST00000677164.1",
"protein_id": "ENSP00000502873.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 1374,
"cds_start": 1875,
"cds_end": null,
"cds_length": 4125,
"cdna_start": 2050,
"cdna_end": null,
"cdna_length": 6276,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.1854C>T",
"hgvs_p": "p.Ser618Ser",
"transcript": "NM_001438720.1",
"protein_id": "NP_001425649.1",
"transcript_support_level": null,
"aa_start": 618,
"aa_end": null,
"aa_length": 1367,
"cds_start": 1854,
"cds_end": null,
"cds_length": 4104,
"cdna_start": 1990,
"cdna_end": null,
"cdna_length": 6012,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2160C>T",
"hgvs_p": "p.Ser720Ser",
"transcript": "XM_047434131.1",
"protein_id": "XP_047290087.1",
"transcript_support_level": null,
"aa_start": 720,
"aa_end": null,
"aa_length": 1584,
"cds_start": 2160,
"cds_end": null,
"cds_length": 4755,
"cdna_start": 3557,
"cdna_end": null,
"cdna_length": 7924,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2055C>T",
"hgvs_p": "p.Ser685Ser",
"transcript": "XM_017023237.2",
"protein_id": "XP_016878726.1",
"transcript_support_level": null,
"aa_start": 685,
"aa_end": null,
"aa_length": 1549,
"cds_start": 2055,
"cds_end": null,
"cds_length": 4650,
"cdna_start": 2058,
"cdna_end": null,
"cdna_length": 6425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2034C>T",
"hgvs_p": "p.Ser678Ser",
"transcript": "XM_047434132.1",
"protein_id": "XP_047290088.1",
"transcript_support_level": null,
"aa_start": 678,
"aa_end": null,
"aa_length": 1542,
"cds_start": 2034,
"cds_end": null,
"cds_length": 4629,
"cdna_start": 3431,
"cdna_end": null,
"cdna_length": 7798,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2022C>T",
"hgvs_p": "p.Ser674Ser",
"transcript": "XM_047434133.1",
"protein_id": "XP_047290089.1",
"transcript_support_level": null,
"aa_start": 674,
"aa_end": null,
"aa_length": 1538,
"cds_start": 2022,
"cds_end": null,
"cds_length": 4617,
"cdna_start": 3419,
"cdna_end": null,
"cdna_length": 7786,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2019C>T",
"hgvs_p": "p.Ser673Ser",
"transcript": "XM_047434134.1",
"protein_id": "XP_047290090.1",
"transcript_support_level": null,
"aa_start": 673,
"aa_end": null,
"aa_length": 1537,
"cds_start": 2019,
"cds_end": null,
"cds_length": 4614,
"cdna_start": 2071,
"cdna_end": null,
"cdna_length": 6438,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2013C>T",
"hgvs_p": "p.Ser671Ser",
"transcript": "XM_047434135.1",
"protein_id": "XP_047290091.1",
"transcript_support_level": null,
"aa_start": 671,
"aa_end": null,
"aa_length": 1535,
"cds_start": 2013,
"cds_end": null,
"cds_length": 4608,
"cdna_start": 3410,
"cdna_end": null,
"cdna_length": 7777,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABCC1",
"gene_hgnc_id": 51,
"hgvs_c": "c.2160C>T",
"hgvs_p": "p.Ser720Ser",
"transcript": "XM_047434136.1",
"protein_id": "XP_047290092.1",
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}