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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-20348509-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=20348509&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 20348509,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001378234.1",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "NM_003361.4",
"protein_id": "NP_003352.2",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000396138.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003361.4"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000396138.9",
"protein_id": "ENSP00000379442.5",
"transcript_support_level": 5,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003361.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396138.9"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.891G>A",
"hgvs_p": "p.Val297Val",
"transcript": "ENST00000396134.6",
"protein_id": "ENSP00000379438.2",
"transcript_support_level": 2,
"aa_start": 297,
"aa_end": null,
"aa_length": 673,
"cds_start": 891,
"cds_end": null,
"cds_length": 2022,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396134.6"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.954G>A",
"hgvs_p": "p.Val318Val",
"transcript": "ENST00000863077.1",
"protein_id": "ENSP00000533136.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 694,
"cds_start": 954,
"cds_end": null,
"cds_length": 2085,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863077.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863084.1",
"protein_id": "ENSP00000533143.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 691,
"cds_start": 792,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863084.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863087.1",
"protein_id": "ENSP00000533146.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 691,
"cds_start": 792,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863087.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "NM_001378234.1",
"protein_id": "NP_001365163.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 687,
"cds_start": 792,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378234.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "NM_001378235.1",
"protein_id": "NP_001365164.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 687,
"cds_start": 792,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378235.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.891G>A",
"hgvs_p": "p.Val297Val",
"transcript": "NM_001278614.2",
"protein_id": "NP_001265543.1",
"transcript_support_level": null,
"aa_start": 297,
"aa_end": null,
"aa_length": 673,
"cds_start": 891,
"cds_end": null,
"cds_length": 2022,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001278614.2"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.861G>A",
"hgvs_p": "p.Val287Val",
"transcript": "ENST00000863082.1",
"protein_id": "ENSP00000533141.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 663,
"cds_start": 861,
"cds_end": null,
"cds_length": 1992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863082.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "NM_001008389.3",
"protein_id": "NP_001008390.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001008389.3"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "NM_001378232.1",
"protein_id": "NP_001365161.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378232.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "NM_001378233.1",
"protein_id": "NP_001365162.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378233.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000570689.5",
"protein_id": "ENSP00000460548.1",
"transcript_support_level": 5,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000570689.5"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863071.1",
"protein_id": "ENSP00000533130.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863071.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863072.1",
"protein_id": "ENSP00000533131.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863072.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863073.1",
"protein_id": "ENSP00000533132.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863073.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863075.1",
"protein_id": "ENSP00000533134.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863075.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863076.1",
"protein_id": "ENSP00000533135.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863076.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863078.1",
"protein_id": "ENSP00000533137.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863078.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863080.1",
"protein_id": "ENSP00000533139.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863080.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UMOD",
"gene_hgnc_id": 12559,
"hgvs_c": "c.792G>A",
"hgvs_p": "p.Val264Val",
"transcript": "ENST00000863081.1",
"protein_id": "ENSP00000533140.1",
"transcript_support_level": null,
"aa_start": 264,
"aa_end": null,
"aa_length": 640,
"cds_start": 792,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863081.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
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}