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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-259156-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=259156&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 259156,
"ref": "C",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000399932.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "NM_032039.4",
"protein_id": "NP_114428.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": -4,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2909,
"mane_select": "ENST00000399932.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000399932.8",
"protein_id": "ENSP00000382814.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": -4,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2909,
"mane_select": "NM_032039.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000301678.7",
"protein_id": "ENSP00000301678.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": -4,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2901,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "NM_001284497.2",
"protein_id": "NP_001271426.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": -4,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2902,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000301679.7",
"protein_id": "ENSP00000301679.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 540,
"cds_start": -4,
"cds_end": null,
"cds_length": 1623,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3326,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000449945.5",
"protein_id": "ENSP00000407669.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 241,
"cds_start": -4,
"cds_end": null,
"cds_length": 728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 887,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000453430.5",
"protein_id": "ENSP00000399150.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 235,
"cds_start": -4,
"cds_end": null,
"cds_length": 708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 984,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.53-327C>G",
"hgvs_p": null,
"transcript": "ENST00000421000.1",
"protein_id": "ENSP00000412581.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 233,
"cds_start": -4,
"cds_end": null,
"cds_length": 702,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 739,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000420046.5",
"protein_id": "ENSP00000398433.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 232,
"cds_start": -4,
"cds_end": null,
"cds_length": 699,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1006,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000438220.5",
"protein_id": "ENSP00000402119.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 130,
"cds_start": -4,
"cds_end": null,
"cds_length": 393,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 554,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-813C>G",
"hgvs_p": null,
"transcript": "ENST00000420500.5",
"protein_id": "ENSP00000409309.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
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"gene_symbol": "FAM234A",
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"transcript": "ENST00000419173.5",
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"cdna_start": null,
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"feature": null
},
{
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"strand": true,
"consequences": [
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],
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"exon_count": 2,
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"gene_symbol": "FAM234A",
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"hgvs_c": "n.561-327C>G",
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"transcript": "ENST00000496874.1",
"protein_id": null,
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},
{
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"strand": true,
"consequences": [
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],
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"exon_count": 13,
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"gene_symbol": "FAM234A",
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"hgvs_c": "n.269-327C>G",
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"transcript": "ENST00000600536.1",
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},
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],
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"transcript": "ENST00000653392.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "FAM234A",
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"hgvs_c": "n.269-327C>G",
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"transcript": "ENST00000654053.1",
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},
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],
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"gene_symbol": "FAM234A",
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"hgvs_c": "n.269-327C>G",
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"transcript": "ENST00000659283.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "n.269-327C>G",
"hgvs_p": null,
"transcript": "ENST00000666018.1",
"protein_id": "ENSP00000499687.1",
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},
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "n.445-327C>G",
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"transcript": "NR_104317.2",
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},
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],
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"hgvs_c": "c.269-327C>G",
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"protein_id": "XP_005255679.1",
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],
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},
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"strand": true,
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],
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"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "XM_011522692.2",
"protein_id": "XP_011520994.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FAM234A",
"gene_hgnc_id": 14163,
"hgvs_c": "c.269-327C>G",
"hgvs_p": null,
"transcript": "XM_017023760.3",
"protein_id": "XP_016879249.1",
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},
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