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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-28606999-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=28606999&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 28606999,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000314752.12",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_001055.4",
"protein_id": "NP_001046.2",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 569,
"cdna_end": null,
"cdna_length": 1569,
"mane_select": "ENST00000314752.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "ENST00000314752.12",
"protein_id": "ENSP00000321988.7",
"transcript_support_level": 1,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 569,
"cdna_end": null,
"cdna_length": 1569,
"mane_select": "NM_001055.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "ENST00000569554.5",
"protein_id": "ENSP00000457912.1",
"transcript_support_level": 1,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 516,
"cdna_end": null,
"cdna_length": 1578,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000289755",
"gene_hgnc_id": null,
"hgvs_c": "n.1210G>C",
"hgvs_p": null,
"transcript": "ENST00000562058.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1876,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000289755",
"gene_hgnc_id": null,
"hgvs_c": "n.982G>C",
"hgvs_p": null,
"transcript": "ENST00000564818.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1653,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_001394421.1",
"protein_id": "NP_001381350.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 1105,
"cdna_end": null,
"cdna_length": 2105,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_001394422.1",
"protein_id": "NP_001381351.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 1904,
"cdna_end": null,
"cdna_length": 2904,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_001394423.1",
"protein_id": "NP_001381352.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 1235,
"cdna_end": null,
"cdna_length": 2235,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_001394424.1",
"protein_id": "NP_001381353.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 802,
"cdna_end": null,
"cdna_length": 1802,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_001394425.1",
"protein_id": "NP_001381354.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 1032,
"cdna_end": null,
"cdna_length": 2032,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_177529.3",
"protein_id": "NP_803565.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 600,
"cdna_end": null,
"cdna_length": 1600,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_177530.4",
"protein_id": "NP_803566.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 1441,
"cdna_end": null,
"cdna_length": 2441,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "NM_177534.4",
"protein_id": "NP_803878.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 295,
"cds_start": 451,
"cds_end": null,
"cds_length": 888,
"cdna_start": 1640,
"cdna_end": null,
"cdna_length": 2640,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "ENST00000566189.5",
"protein_id": "ENSP00000456459.1",
"transcript_support_level": 5,
"aa_start": 151,
"aa_end": null,
"aa_length": 280,
"cds_start": 451,
"cds_end": null,
"cds_length": 844,
"cdna_start": 546,
"cdna_end": null,
"cdna_length": 939,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.148G>C",
"hgvs_p": "p.Glu50Gln",
"transcript": "NM_177536.5",
"protein_id": "NP_803880.2",
"transcript_support_level": null,
"aa_start": 50,
"aa_end": null,
"aa_length": 194,
"cds_start": 148,
"cds_end": null,
"cds_length": 585,
"cdna_start": 395,
"cdna_end": null,
"cdna_length": 1395,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.325G>C",
"hgvs_p": "p.Glu109Gln",
"transcript": "ENST00000567512.1",
"protein_id": "ENSP00000455979.1",
"transcript_support_level": 3,
"aa_start": 109,
"aa_end": null,
"aa_length": 168,
"cds_start": 325,
"cds_end": null,
"cds_length": 509,
"cdna_start": 431,
"cdna_end": null,
"cdna_length": 615,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "XM_017023604.2",
"protein_id": "XP_016879093.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 301,
"cds_start": 451,
"cds_end": null,
"cds_length": 906,
"cdna_start": 645,
"cdna_end": null,
"cdna_length": 1663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "XM_017023605.2",
"protein_id": "XP_016879094.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 301,
"cds_start": 451,
"cds_end": null,
"cds_length": 906,
"cdna_start": 642,
"cdna_end": null,
"cdna_length": 1660,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "XM_017023608.2",
"protein_id": "XP_016879097.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 301,
"cds_start": 451,
"cds_end": null,
"cds_length": 906,
"cdna_start": 569,
"cdna_end": null,
"cdna_length": 1587,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "XM_017023610.2",
"protein_id": "XP_016879099.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 301,
"cds_start": 451,
"cds_end": null,
"cds_length": 906,
"cdna_start": 764,
"cdna_end": null,
"cdna_length": 1782,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "XM_047434544.1",
"protein_id": "XP_047290500.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 301,
"cds_start": 451,
"cds_end": null,
"cds_length": 906,
"cdna_start": 649,
"cdna_end": null,
"cdna_length": 1667,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "XM_047434545.1",
"protein_id": "XP_047290501.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 301,
"cds_start": 451,
"cds_end": null,
"cds_length": 906,
"cdna_start": 733,
"cdna_end": null,
"cdna_length": 1751,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SULT1A1",
"gene_hgnc_id": 11453,
"hgvs_c": "c.451G>C",
"hgvs_p": "p.Glu151Gln",
"transcript": "XM_047434546.1",
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],
"message": null
}