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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-2975773-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=2975773&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "16",
      "pos": 2975773,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "ENST00000262300.13",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys",
          "transcript": "NM_004203.5",
          "protein_id": "NP_004194.3",
          "transcript_support_level": null,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 499,
          "cds_start": 418,
          "cds_end": null,
          "cds_length": 1500,
          "cdna_start": 834,
          "cdna_end": null,
          "cdna_length": 2061,
          "mane_select": "ENST00000262300.13",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys",
          "transcript": "ENST00000262300.13",
          "protein_id": "ENSP00000262300.8",
          "transcript_support_level": 1,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 499,
          "cds_start": 418,
          "cds_end": null,
          "cds_length": 1500,
          "cdna_start": 834,
          "cdna_end": null,
          "cdna_length": 2061,
          "mane_select": "NM_004203.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys",
          "transcript": "ENST00000431515.6",
          "protein_id": "ENSP00000392855.2",
          "transcript_support_level": 2,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 568,
          "cds_start": 418,
          "cds_end": null,
          "cds_length": 1707,
          "cdna_start": 804,
          "cdna_end": null,
          "cdna_length": 2308,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys",
          "transcript": "NM_001438149.1",
          "protein_id": "NP_001425078.1",
          "transcript_support_level": null,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 499,
          "cds_start": 418,
          "cds_end": null,
          "cds_length": 1500,
          "cdna_start": 878,
          "cdna_end": null,
          "cdna_length": 2105,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys",
          "transcript": "NM_001438150.1",
          "protein_id": "NP_001425079.1",
          "transcript_support_level": null,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 499,
          "cds_start": 418,
          "cds_end": null,
          "cds_length": 1500,
          "cdna_start": 901,
          "cdna_end": null,
          "cdna_length": 2128,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys",
          "transcript": "NM_001438151.1",
          "protein_id": "NP_001425080.1",
          "transcript_support_level": null,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 499,
          "cds_start": 418,
          "cds_end": null,
          "cds_length": 1500,
          "cdna_start": 915,
          "cdna_end": null,
          "cdna_length": 2142,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.391C>T",
          "hgvs_p": "p.Arg131Cys",
          "transcript": "NM_001258451.2",
          "protein_id": "NP_001245380.1",
          "transcript_support_level": null,
          "aa_start": 131,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": 391,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": 698,
          "cdna_end": null,
          "cdna_length": 1925,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.391C>T",
          "hgvs_p": "p.Arg131Cys",
          "transcript": "NM_001437991.1",
          "protein_id": "NP_001424920.1",
          "transcript_support_level": null,
          "aa_start": 131,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": 391,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": 674,
          "cdna_end": null,
          "cdna_length": 1901,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.391C>T",
          "hgvs_p": "p.Arg131Cys",
          "transcript": "ENST00000573944.5",
          "protein_id": "ENSP00000459123.1",
          "transcript_support_level": 5,
          "aa_start": 131,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": 391,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": 707,
          "cdna_end": null,
          "cdna_length": 1891,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.391C>T",
          "hgvs_p": "p.Arg131Cys",
          "transcript": "ENST00000574385.5",
          "protein_id": "ENSP00000458943.1",
          "transcript_support_level": 2,
          "aa_start": 131,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": 391,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": 676,
          "cdna_end": null,
          "cdna_length": 1892,
          "mane_select": null,
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          "biotype": null,
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        },
        {
          "aa_ref": "R",
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          "strand": false,
          "consequences": [
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys",
          "transcript": "NM_182687.3",
          "protein_id": "NP_872629.1",
          "transcript_support_level": null,
          "aa_start": 140,
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          "cds_start": 418,
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          "cds_length": 1443,
          "cdna_start": 834,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 4,
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          "intron_rank": null,
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          "gene_symbol": "PKMYT1",
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          "hgvs_c": "c.418C>T",
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          "transcript": "ENST00000440027.6",
          "protein_id": "ENSP00000397739.2",
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          "cdna_start": 779,
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          "mane_select": null,
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        {
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          "consequences": [
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          ],
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          "gene_symbol": "PKMYT1",
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          "hgvs_c": "c.211C>T",
          "hgvs_p": "p.Arg71Cys",
          "transcript": "NM_001258450.2",
          "protein_id": "NP_001245379.1",
          "transcript_support_level": null,
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          "cdna_start": 627,
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        {
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          "strand": false,
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          ],
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          "intron_rank": null,
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          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.211C>T",
          "hgvs_p": "p.Arg71Cys",
          "transcript": "ENST00000574730.5",
          "protein_id": "ENSP00000460868.1",
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          "cds_start": 211,
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          "cdna_start": 620,
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        },
        {
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        {
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          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.526C>T",
          "hgvs_p": "p.Arg176Cys",
          "transcript": "ENST00000574415.5",
          "protein_id": "ENSP00000460598.1",
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          "cds_start": 526,
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        {
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          "intron_rank": null,
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          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
          "hgvs_c": "c.418C>T",
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          "transcript": "ENST00000575632.5",
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        {
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        {
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          "gene_symbol": "PKMYT1",
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          "hgvs_c": "c.445C>T",
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        {
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          "gene_symbol": "PKMYT1",
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          "hgvs_c": "c.445C>T",
          "hgvs_p": "p.Arg149Cys",
          "transcript": "XM_047434869.1",
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          "biotype": null,
          "feature": null
        },
        {
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          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "PKMYT1",
          "gene_hgnc_id": 29650,
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        {
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          "hgvs_c": "n.391C>T",
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          "transcript": "ENST00000382240.9",
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      ],
      "gene_symbol": "PKMYT1",
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      "dbsnp": "rs4149796",
      "frequency_reference_population": 0.00015942243,
      "hom_count_reference_population": 1,
      "allele_count_reference_population": 255,
      "gnomad_exomes_af": 0.000147877,
      "gnomad_genomes_af": 0.000269078,
      "gnomad_exomes_ac": 214,
      "gnomad_genomes_ac": 41,
      "gnomad_exomes_homalt": 1,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.013270825147628784,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.019999999552965164,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.31,
      "revel_prediction": "Uncertain_significance",
      "alphamissense_score": 0.1104,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": 0.05,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 2.427,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.02,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -4,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -4,
          "benign_score": 4,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000262300.13",
          "gene_symbol": "PKMYT1",
          "hgnc_id": 29650,
          "effects": [
            "missense_variant"
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          "inheritance_mode": "AR",
          "hgvs_c": "c.418C>T",
          "hgvs_p": "p.Arg140Cys"
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      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}