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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-29790783-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=29790783&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 29790783,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_007317.3",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "NM_007317.3",
"protein_id": "NP_015556.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 665,
"cds_start": 24,
"cds_end": null,
"cds_length": 1998,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000160827.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007317.3"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000160827.9",
"protein_id": "ENSP00000160827.5",
"transcript_support_level": 1,
"aa_start": 8,
"aa_end": null,
"aa_length": 665,
"cds_start": 24,
"cds_end": null,
"cds_length": 1998,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_007317.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000160827.9"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000569382.3",
"protein_id": "ENSP00000456165.3",
"transcript_support_level": 5,
"aa_start": 8,
"aa_end": null,
"aa_length": 679,
"cds_start": 24,
"cds_end": null,
"cds_length": 2040,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000569382.3"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936369.1",
"protein_id": "ENSP00000606428.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 679,
"cds_start": 24,
"cds_end": null,
"cds_length": 2040,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936369.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936371.1",
"protein_id": "ENSP00000606430.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 672,
"cds_start": 24,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936371.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936373.1",
"protein_id": "ENSP00000606432.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 667,
"cds_start": 24,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936373.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936374.1",
"protein_id": "ENSP00000606433.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 666,
"cds_start": 24,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936374.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936370.1",
"protein_id": "ENSP00000606429.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 663,
"cds_start": 24,
"cds_end": null,
"cds_length": 1992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936370.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936372.1",
"protein_id": "ENSP00000606431.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 656,
"cds_start": 24,
"cds_end": null,
"cds_length": 1971,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936372.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000689660.1",
"protein_id": "ENSP00000509285.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 649,
"cds_start": 24,
"cds_end": null,
"cds_length": 1950,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000689660.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000689107.1",
"protein_id": "ENSP00000509175.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 645,
"cds_start": 24,
"cds_end": null,
"cds_length": 1938,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000689107.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936380.1",
"protein_id": "ENSP00000606439.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 642,
"cds_start": 24,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936380.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936378.1",
"protein_id": "ENSP00000606437.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 639,
"cds_start": 24,
"cds_end": null,
"cds_length": 1920,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936378.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936379.1",
"protein_id": "ENSP00000606438.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 636,
"cds_start": 24,
"cds_end": null,
"cds_length": 1911,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936379.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936377.1",
"protein_id": "ENSP00000606436.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 610,
"cds_start": 24,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936377.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936375.1",
"protein_id": "ENSP00000606434.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 595,
"cds_start": 24,
"cds_end": null,
"cds_length": 1788,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936375.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "ENST00000936376.1",
"protein_id": "ENSP00000606435.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 574,
"cds_start": 24,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936376.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "XM_047434094.1",
"protein_id": "XP_047290050.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 542,
"cds_start": 24,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047434094.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.24G>A",
"hgvs_p": "p.Gln8Gln",
"transcript": "XM_047434095.1",
"protein_id": "XP_047290051.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 442,
"cds_start": 24,
"cds_end": null,
"cds_length": 1329,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047434095.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.-230G>A",
"hgvs_p": null,
"transcript": "NM_001256269.2",
"protein_id": "NP_001243198.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 597,
"cds_start": null,
"cds_end": null,
"cds_length": 1794,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256269.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "c.-230G>A",
"hgvs_p": null,
"transcript": "ENST00000690258.1",
"protein_id": "ENSP00000509977.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 597,
"cds_start": null,
"cds_end": null,
"cds_length": 1794,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000690258.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIF22",
"gene_hgnc_id": 6391,
"hgvs_c": "n.53G>A",
"hgvs_p": null,
"transcript": "ENST00000563666.2",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
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}