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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-29810132-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=29810132&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "16",
      "pos": 29810132,
      "ref": "A",
      "alt": "G",
      "effect": "synonymous_variant",
      "transcript": "NM_002383.4",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.1335A>G",
          "hgvs_p": "p.Ala445Ala",
          "transcript": "NM_002383.4",
          "protein_id": "NP_002374.2",
          "transcript_support_level": null,
          "aa_start": 445,
          "aa_end": null,
          "aa_length": 477,
          "cds_start": 1335,
          "cds_end": null,
          "cds_length": 1434,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000322945.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002383.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.1335A>G",
          "hgvs_p": "p.Ala445Ala",
          "transcript": "ENST00000322945.11",
          "protein_id": "ENSP00000313362.6",
          "transcript_support_level": 1,
          "aa_start": 445,
          "aa_end": null,
          "aa_length": 477,
          "cds_start": 1335,
          "cds_end": null,
          "cds_length": 1434,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_002383.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000322945.11"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.1266A>G",
          "hgvs_p": "p.Ala422Ala",
          "transcript": "ENST00000545521.5",
          "protein_id": "ENSP00000443956.1",
          "transcript_support_level": 1,
          "aa_start": 422,
          "aa_end": null,
          "aa_length": 454,
          "cds_start": 1266,
          "cds_end": null,
          "cds_length": 1365,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000545521.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.*78A>G",
          "hgvs_p": null,
          "transcript": "ENST00000219782.11",
          "protein_id": "ENSP00000219782.6",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 493,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1482,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000219782.11"
        },
        {
          "aa_ref": "S",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.304A>G",
          "hgvs_p": "p.Ser102Gly",
          "transcript": "ENST00000563402.1",
          "protein_id": "ENSP00000457310.1",
          "transcript_support_level": 5,
          "aa_start": 102,
          "aa_end": null,
          "aa_length": 186,
          "cds_start": 304,
          "cds_end": null,
          "cds_length": 561,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000563402.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "G",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.298A>G",
          "hgvs_p": "p.Ser100Gly",
          "transcript": "ENST00000566906.6",
          "protein_id": "ENSP00000461174.1",
          "transcript_support_level": 5,
          "aa_start": 100,
          "aa_end": null,
          "aa_length": 184,
          "cds_start": 298,
          "cds_end": null,
          "cds_length": 555,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000566906.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.1266A>G",
          "hgvs_p": "p.Ala422Ala",
          "transcript": "NM_001276275.2",
          "protein_id": "NP_001263204.1",
          "transcript_support_level": null,
          "aa_start": 422,
          "aa_end": null,
          "aa_length": 454,
          "cds_start": 1266,
          "cds_end": null,
          "cds_length": 1365,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001276275.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.345A>G",
          "hgvs_p": "p.Ala115Ala",
          "transcript": "ENST00000568411.5",
          "protein_id": "ENSP00000455794.1",
          "transcript_support_level": 3,
          "aa_start": 115,
          "aa_end": null,
          "aa_length": 195,
          "cds_start": 345,
          "cds_end": null,
          "cds_length": 588,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000568411.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.420A>G",
          "hgvs_p": "p.Ala140Ala",
          "transcript": "NM_001276276.2",
          "protein_id": "NP_001263205.1",
          "transcript_support_level": null,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 172,
          "cds_start": 420,
          "cds_end": null,
          "cds_length": 519,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001276276.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.420A>G",
          "hgvs_p": "p.Ala140Ala",
          "transcript": "ENST00000562337.5",
          "protein_id": "ENSP00000455726.1",
          "transcript_support_level": 3,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 172,
          "cds_start": 420,
          "cds_end": null,
          "cds_length": 519,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000562337.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.360A>G",
          "hgvs_p": "p.Ala120Ala",
          "transcript": "ENST00000563012.1",
          "protein_id": "ENSP00000455913.1",
          "transcript_support_level": 3,
          "aa_start": 120,
          "aa_end": null,
          "aa_length": 152,
          "cds_start": 360,
          "cds_end": null,
          "cds_length": 459,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000563012.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.138A>G",
          "hgvs_p": "p.Ala46Ala",
          "transcript": "ENST00000568544.5",
          "protein_id": "ENSP00000455473.1",
          "transcript_support_level": 2,
          "aa_start": 46,
          "aa_end": null,
          "aa_length": 78,
          "cds_start": 138,
          "cds_end": null,
          "cds_length": 237,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000568544.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.*78A>G",
          "hgvs_p": null,
          "transcript": "NM_001042539.3",
          "protein_id": "NP_001036004.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 493,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1482,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001042539.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "c.*74A>G",
          "hgvs_p": null,
          "transcript": "ENST00000568282.1",
          "protein_id": "ENSP00000458201.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 94,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 285,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000568282.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "n.*229A>G",
          "hgvs_p": null,
          "transcript": "ENST00000561855.1",
          "protein_id": "ENSP00000456179.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000561855.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000280607",
          "gene_hgnc_id": null,
          "hgvs_c": "n.119A>G",
          "hgvs_p": null,
          "transcript": "ENST00000562594.2",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000562594.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "n.378A>G",
          "hgvs_p": null,
          "transcript": "ENST00000565777.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000565777.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MVP-DT",
          "gene_hgnc_id": 56029,
          "hgvs_c": "n.287T>C",
          "hgvs_p": null,
          "transcript": "ENST00000569039.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000569039.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MVP-DT",
          "gene_hgnc_id": 56029,
          "hgvs_c": "n.1854T>C",
          "hgvs_p": null,
          "transcript": "ENST00000569981.2",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000569981.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MVP-DT",
          "gene_hgnc_id": 56029,
          "hgvs_c": "n.669T>C",
          "hgvs_p": null,
          "transcript": "ENST00000818124.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000818124.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "MVP-DT",
          "gene_hgnc_id": 56029,
          "hgvs_c": "n.511T>C",
          "hgvs_p": null,
          "transcript": "ENST00000818125.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "pseudogene",
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        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
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          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "MVP-DT",
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          "hgvs_c": "n.464T>C",
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          "transcript": "ENST00000818126.1",
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        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": false,
          "consequences": [
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          "exon_rank": 3,
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          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "MVP-DT",
          "gene_hgnc_id": 56029,
          "hgvs_c": "n.462T>C",
          "hgvs_p": null,
          "transcript": "ENST00000818127.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cdna_start": null,
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          "biotype": "pseudogene",
          "feature": "ENST00000818127.1"
        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "n.657A>G",
          "hgvs_p": null,
          "transcript": "NR_074080.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "pseudogene",
          "feature": "NR_074080.2"
        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 3,
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          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "MVP-DT",
          "gene_hgnc_id": 56029,
          "hgvs_c": "n.288T>C",
          "hgvs_p": null,
          "transcript": "NR_186424.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "NR_186424.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "MAZ",
          "gene_hgnc_id": 6914,
          "hgvs_c": "n.*229A>G",
          "hgvs_p": null,
          "transcript": "ENST00000561855.1",
          "protein_id": "ENSP00000456179.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000561855.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MVP-DT",
          "gene_hgnc_id": 56029,
          "hgvs_c": "n.-34T>C",
          "hgvs_p": null,
          "transcript": "ENST00000818129.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000818129.1"
        }
      ],
      "gene_symbol": "MAZ",
      "gene_hgnc_id": 6914,
      "dbsnp": "rs370120877",
      "frequency_reference_population": 0.0009945477,
      "hom_count_reference_population": 2,
      "allele_count_reference_population": 1599,
      "gnomad_exomes_af": 0.00101965,
      "gnomad_genomes_af": 0.000753022,
      "gnomad_exomes_ac": 1485,
      "gnomad_genomes_ac": 114,
      "gnomad_exomes_homalt": 2,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.004021674394607544,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": 0.0753,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.44,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -2.116,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -11,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Moderate,BP7,BS2",
      "acmg_by_gene": [
        {
          "score": -11,
          "benign_score": 11,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Moderate",
            "BP7",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "NM_002383.4",
          "gene_symbol": "MAZ",
          "hgnc_id": 6914,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.1335A>G",
          "hgvs_p": "p.Ala445Ala"
        },
        {
          "score": -10,
          "benign_score": 10,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Moderate",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000569039.5",
          "gene_symbol": "MVP-DT",
          "hgnc_id": 56029,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.287T>C",
          "hgvs_p": null
        },
        {
          "score": -10,
          "benign_score": 10,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Moderate",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000562594.2",
          "gene_symbol": "ENSG00000280607",
          "hgnc_id": null,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.119A>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}