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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-3068006-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=3068006&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 3068006,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001308078.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.137T>C",
"hgvs_p": "p.Leu46Pro",
"transcript": "NM_001376923.1",
"protein_id": "NP_001363852.1",
"transcript_support_level": null,
"aa_start": 46,
"aa_end": null,
"aa_length": 188,
"cds_start": 137,
"cds_end": null,
"cds_length": 567,
"cdna_start": 213,
"cdna_end": null,
"cdna_length": 818,
"mane_select": "ENST00000525643.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376923.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.137T>C",
"hgvs_p": "p.Leu46Pro",
"transcript": "ENST00000525643.7",
"protein_id": "ENSP00000432218.3",
"transcript_support_level": 1,
"aa_start": 46,
"aa_end": null,
"aa_length": 188,
"cds_start": 137,
"cds_end": null,
"cds_length": 567,
"cdna_start": 213,
"cdna_end": null,
"cdna_length": 818,
"mane_select": "NM_001376923.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525643.7"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000396890.6",
"protein_id": "ENSP00000380099.2",
"transcript_support_level": 1,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 352,
"cdna_end": null,
"cdna_length": 1067,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396890.6"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.137T>C",
"hgvs_p": "p.Leu46Pro",
"transcript": "ENST00000325568.9",
"protein_id": "ENSP00000324742.5",
"transcript_support_level": 1,
"aa_start": 46,
"aa_end": null,
"aa_length": 188,
"cds_start": 137,
"cds_end": null,
"cds_length": 567,
"cdna_start": 363,
"cdna_end": null,
"cdna_length": 1105,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000325568.9"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.107T>C",
"hgvs_p": "p.Leu36Pro",
"transcript": "ENST00000531965.5",
"protein_id": "ENSP00000433177.1",
"transcript_support_level": 1,
"aa_start": 36,
"aa_end": null,
"aa_length": 178,
"cds_start": 107,
"cds_end": null,
"cds_length": 537,
"cdna_start": 295,
"cdna_end": null,
"cdna_length": 746,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000531965.5"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.137T>C",
"hgvs_p": "p.Leu46Pro",
"transcript": "ENST00000529699.5",
"protein_id": "ENSP00000436937.1",
"transcript_support_level": 1,
"aa_start": 46,
"aa_end": null,
"aa_length": 168,
"cds_start": 137,
"cds_end": null,
"cds_length": 507,
"cdna_start": 302,
"cdna_end": null,
"cdna_length": 672,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000529699.5"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.77T>C",
"hgvs_p": "p.Leu26Pro",
"transcript": "ENST00000548246.1",
"protein_id": "ENSP00000447979.1",
"transcript_support_level": 1,
"aa_start": 26,
"aa_end": null,
"aa_length": 148,
"cds_start": 77,
"cds_end": null,
"cds_length": 447,
"cdna_start": 77,
"cdna_end": null,
"cdna_length": 447,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000548246.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.137T>C",
"hgvs_p": "p.Leu46Pro",
"transcript": "ENST00000396887.7",
"protein_id": "ENSP00000380096.3",
"transcript_support_level": 1,
"aa_start": 46,
"aa_end": null,
"aa_length": 131,
"cds_start": 137,
"cds_end": null,
"cds_length": 396,
"cdna_start": 338,
"cdna_end": null,
"cdna_length": 789,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396887.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "n.722T>C",
"hgvs_p": null,
"transcript": "ENST00000532247.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1381,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000532247.5"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "NM_001308078.4",
"protein_id": "NP_001295007.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 351,
"cdna_end": null,
"cdna_length": 956,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001308078.4"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "NM_001369587.3",
"protein_id": "NP_001356516.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 398,
"cdna_end": null,
"cdna_length": 1003,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001369587.3"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "NM_001369588.3",
"protein_id": "NP_001356517.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 395,
"cdna_end": null,
"cdna_length": 1000,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001369588.3"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000534507.5",
"protein_id": "ENSP00000431775.1",
"transcript_support_level": 2,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 486,
"cdna_end": null,
"cdna_length": 1112,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000534507.5"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000548476.5",
"protein_id": "ENSP00000449483.1",
"transcript_support_level": 2,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 425,
"cdna_end": null,
"cdna_length": 1014,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000548476.5"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000878151.1",
"protein_id": "ENSP00000548210.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 384,
"cdna_end": null,
"cdna_length": 2059,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878151.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000878152.1",
"protein_id": "ENSP00000548211.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 352,
"cdna_end": null,
"cdna_length": 2033,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878152.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000878157.1",
"protein_id": "ENSP00000548216.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 328,
"cdna_end": null,
"cdna_length": 1049,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878157.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000878158.1",
"protein_id": "ENSP00000548217.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 383,
"cdna_end": null,
"cdna_length": 1095,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878158.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000878159.1",
"protein_id": "ENSP00000548218.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 386,
"cdna_end": null,
"cdna_length": 1010,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878159.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000878165.1",
"protein_id": "ENSP00000548224.1",
"transcript_support_level": null,
"aa_start": 92,
"aa_end": null,
"aa_length": 234,
"cds_start": 275,
"cds_end": null,
"cds_length": 705,
"cdna_start": 375,
"cdna_end": null,
"cdna_length": 998,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878165.1"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000548807.5",
"protein_id": "ENSP00000448354.1",
"transcript_support_level": 3,
"aa_start": 92,
"aa_end": null,
"aa_length": 224,
"cds_start": 275,
"cds_end": null,
"cds_length": 676,
"cdna_start": 409,
"cdna_end": null,
"cdna_length": 810,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000548807.5"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IL32",
"gene_hgnc_id": 16830,
"hgvs_c": "c.275T>C",
"hgvs_p": "p.Leu92Pro",
"transcript": "ENST00000525377.6",
"protein_id": "ENSP00000433866.3",
"transcript_support_level": 5,
"aa_start": 92,
"aa_end": null,
"aa_length": 221,
"cds_start": 275,
"cds_end": null,
"cds_length": 666,
"cdna_start": 373,
"cdna_end": null,
"cdna_length": 997,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525377.6"
},
{
"aa_ref": "L",
"aa_alt": "P",
"canonical": false,
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}
],
"message": null
}