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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-31718231-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=31718231&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 31718231,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000316491.14",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.4-4395A>T",
"hgvs_p": null,
"transcript": "NM_001130913.2",
"protein_id": "NP_001124385.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 126,
"cds_start": -4,
"cds_end": null,
"cds_length": 381,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2759,
"mane_select": "ENST00000316491.14",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.4-4395A>T",
"hgvs_p": null,
"transcript": "ENST00000316491.14",
"protein_id": "ENSP00000319222.9",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 126,
"cds_start": -4,
"cds_end": null,
"cds_length": 381,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2759,
"mane_select": "NM_001130913.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.126+3814A>T",
"hgvs_p": null,
"transcript": "ENST00000530881.5",
"protein_id": "ENSP00000435171.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 145,
"cds_start": -4,
"cds_end": null,
"cds_length": 440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 570,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "n.17-4395A>T",
"hgvs_p": null,
"transcript": "ENST00000534277.5",
"protein_id": "ENSP00000434091.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5994,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.10-4395A>T",
"hgvs_p": null,
"transcript": "NM_001394173.1",
"protein_id": "NP_001381102.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 543,
"cds_start": -4,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5995,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.4-4395A>T",
"hgvs_p": null,
"transcript": "NM_001394174.1",
"protein_id": "NP_001381103.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 541,
"cds_start": -4,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5982,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.4-4395A>T",
"hgvs_p": null,
"transcript": "ENST00000529515.2",
"protein_id": "ENSP00000437310.2",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 541,
"cds_start": -4,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5982,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-94+3941A>T",
"hgvs_p": null,
"transcript": "NM_001394175.1",
"protein_id": "NP_001381104.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 509,
"cds_start": -4,
"cds_end": null,
"cds_length": 1530,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6188,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.3+4796A>T",
"hgvs_p": null,
"transcript": "NM_001394176.1",
"protein_id": "NP_001381105.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 487,
"cds_start": -4,
"cds_end": null,
"cds_length": 1464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5820,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-256-4395A>T",
"hgvs_p": null,
"transcript": "NM_001394177.1",
"protein_id": "NP_001381106.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 475,
"cds_start": -4,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6115,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-34+3941A>T",
"hgvs_p": null,
"transcript": "NM_001394178.1",
"protein_id": "NP_001381107.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 475,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 6026,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-312-4395A>T",
"hgvs_p": null,
"transcript": "NM_001394179.1",
"protein_id": "NP_001381108.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-257+3814A>T",
"hgvs_p": null,
"transcript": "NM_001394180.1",
"protein_id": "NP_001381109.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-234-682A>T",
"hgvs_p": null,
"transcript": "NM_001394181.1",
"protein_id": "NP_001381110.1",
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"aa_start": null,
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},
{
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"strand": true,
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],
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"exon_count": 3,
"intron_rank": 1,
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"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.4-4395A>T",
"hgvs_p": null,
"transcript": "NM_001394182.1",
"protein_id": "NP_001381111.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-234-682A>T",
"hgvs_p": null,
"transcript": "NM_001394183.1",
"protein_id": "NP_001381112.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-453-4395A>T",
"hgvs_p": null,
"transcript": "NM_001394184.1",
"protein_id": "NP_001381113.1",
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"cds_start": -4,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.16+4783A>T",
"hgvs_p": null,
"transcript": "ENST00000398696.3",
"protein_id": "ENSP00000443758.1",
"transcript_support_level": 4,
"aa_start": null,
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"aa_length": 178,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.4-4395A>T",
"hgvs_p": null,
"transcript": "NM_001394185.1",
"protein_id": "NP_001381114.1",
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},
{
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"strand": true,
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],
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"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.3+4796A>T",
"hgvs_p": null,
"transcript": "ENST00000534369.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRABD5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-234-682A>T",
"hgvs_p": null,
"transcript": "NM_001394186.1",
"protein_id": "NP_001381115.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.-94+3941A>T",
"hgvs_p": null,
"transcript": "ENST00000689850.1",
"protein_id": "ENSP00000509660.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KRBOX5",
"gene_hgnc_id": 26987,
"hgvs_c": "c.16+4783A>T",
"hgvs_p": null,
"transcript": "ENST00000539915.5",
"protein_id": "ENSP00000441893.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
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}