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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-3223938-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=3223938&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 3223938,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_003454.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "NM_198088.3",
"protein_id": "NP_932354.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000414144.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_198088.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000414144.7",
"protein_id": "ENSP00000405786.2",
"transcript_support_level": 1,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_198088.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000414144.7"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000431561.7",
"protein_id": "ENSP00000395723.3",
"transcript_support_level": 1,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000431561.7"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000396868.7",
"protein_id": "ENSP00000380077.3",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396868.7"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000396870.8",
"protein_id": "ENSP00000380079.4",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396870.8"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000396871.8",
"protein_id": "ENSP00000380080.4",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396871.8"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000575948.1",
"protein_id": "ENSP00000458508.1",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000575948.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1259G>T",
"hgvs_p": "p.Arg420Leu",
"transcript": "ENST00000854062.1",
"protein_id": "ENSP00000524121.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 434,
"cds_start": 1259,
"cds_end": null,
"cds_length": 1305,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854062.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1256G>T",
"hgvs_p": "p.Arg419Leu",
"transcript": "ENST00000854059.1",
"protein_id": "ENSP00000524118.1",
"transcript_support_level": null,
"aa_start": 419,
"aa_end": null,
"aa_length": 433,
"cds_start": 1256,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854059.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "NM_003454.4",
"protein_id": "NP_003445.2",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003454.4"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000854057.1",
"protein_id": "ENSP00000524116.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854057.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000854058.1",
"protein_id": "ENSP00000524117.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854058.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000854060.1",
"protein_id": "ENSP00000524119.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854060.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000854061.1",
"protein_id": "ENSP00000524120.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854061.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000854063.1",
"protein_id": "ENSP00000524122.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854063.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000946755.1",
"protein_id": "ENSP00000616814.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946755.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1142G>T",
"hgvs_p": "p.Arg381Leu",
"transcript": "ENST00000946756.1",
"protein_id": "ENSP00000616815.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 395,
"cds_start": 1142,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946756.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "NM_001145446.2",
"protein_id": "NP_001138918.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145446.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "NM_001145447.2",
"protein_id": "NP_001138919.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145447.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "NM_001145448.2",
"protein_id": "NP_001138920.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145448.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "NM_198087.3",
"protein_id": "NP_932353.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_198087.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF200",
"gene_hgnc_id": 12993,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000854056.1",
"protein_id": "ENSP00000524115.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 394,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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}
],
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}