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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-4506910-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=4506910&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 4506910,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000570646.6",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "NM_002134.4",
"protein_id": "NP_002125.3",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 233,
"cdna_end": null,
"cdna_length": 1673,
"mane_select": "ENST00000570646.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000570646.6",
"protein_id": "ENSP00000459214.1",
"transcript_support_level": 1,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 233,
"cdna_end": null,
"cdna_length": 1673,
"mane_select": "NM_002134.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.264G>A",
"hgvs_p": "p.Ser88Ser",
"transcript": "NM_001286267.2",
"protein_id": "NP_001273196.1",
"transcript_support_level": null,
"aa_start": 88,
"aa_end": null,
"aa_length": 370,
"cds_start": 264,
"cds_end": null,
"cds_length": 1113,
"cdna_start": 354,
"cdna_end": null,
"cdna_length": 1794,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.264G>A",
"hgvs_p": "p.Ser88Ser",
"transcript": "ENST00000613539.1",
"protein_id": "ENSP00000477572.1",
"transcript_support_level": 5,
"aa_start": 88,
"aa_end": null,
"aa_length": 370,
"cds_start": 264,
"cds_end": null,
"cds_length": 1113,
"cdna_start": 264,
"cdna_end": null,
"cdna_length": 1703,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "NM_001127204.2",
"protein_id": "NP_001120676.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 351,
"cdna_end": null,
"cdna_length": 1791,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "NM_001127205.2",
"protein_id": "NP_001120677.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 313,
"cdna_end": null,
"cdna_length": 1753,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "NM_001127206.3",
"protein_id": "NP_001120678.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 255,
"cdna_end": null,
"cdna_length": 1695,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "NM_001286268.2",
"protein_id": "NP_001273197.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 411,
"cdna_end": null,
"cdna_length": 1851,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "NM_001286269.2",
"protein_id": "NP_001273198.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 332,
"cdna_end": null,
"cdna_length": 1772,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "NM_001286270.2",
"protein_id": "NP_001273199.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 650,
"cdna_end": null,
"cdna_length": 2090,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000219700.10",
"protein_id": "ENSP00000219700.6",
"transcript_support_level": 5,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 182,
"cdna_end": null,
"cdna_length": 1621,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000398595.7",
"protein_id": "ENSP00000381595.3",
"transcript_support_level": 2,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 650,
"cdna_end": null,
"cdna_length": 1644,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000406590.6",
"protein_id": "ENSP00000385100.2",
"transcript_support_level": 5,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 288,
"cdna_end": null,
"cdna_length": 1727,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000414777.5",
"protein_id": "ENSP00000391637.1",
"transcript_support_level": 5,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 313,
"cdna_end": null,
"cdna_length": 1752,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000458134.7",
"protein_id": "ENSP00000394103.3",
"transcript_support_level": 5,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 409,
"cdna_end": null,
"cdna_length": 1797,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000619528.4",
"protein_id": "ENSP00000484423.1",
"transcript_support_level": 5,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 390,
"cdna_end": null,
"cdna_length": 1829,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000619913.4",
"protein_id": "ENSP00000484467.1",
"transcript_support_level": 5,
"aa_start": 34,
"aa_end": null,
"aa_length": 316,
"cds_start": 102,
"cds_end": null,
"cds_length": 951,
"cdna_start": 469,
"cdna_end": null,
"cdna_length": 1908,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.15G>A",
"hgvs_p": "p.Ser5Ser",
"transcript": "NM_001286271.2",
"protein_id": "NP_001273200.1",
"transcript_support_level": null,
"aa_start": 5,
"aa_end": null,
"aa_length": 287,
"cds_start": 15,
"cds_end": null,
"cds_length": 864,
"cdna_start": 106,
"cdna_end": null,
"cdna_length": 1546,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.15G>A",
"hgvs_p": "p.Ser5Ser",
"transcript": "ENST00000575120.5",
"protein_id": "ENSP00000460926.1",
"transcript_support_level": 3,
"aa_start": 5,
"aa_end": null,
"aa_length": 287,
"cds_start": 15,
"cds_end": null,
"cds_length": 864,
"cdna_start": 98,
"cdna_end": null,
"cdna_length": 1027,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000575051.5",
"protein_id": "ENSP00000458797.1",
"transcript_support_level": 5,
"aa_start": 34,
"aa_end": null,
"aa_length": 237,
"cds_start": 102,
"cds_end": null,
"cds_length": 715,
"cdna_start": 301,
"cdna_end": null,
"cdna_length": 914,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000570445.5",
"protein_id": "ENSP00000458592.1",
"transcript_support_level": 2,
"aa_start": 34,
"aa_end": null,
"aa_length": 228,
"cds_start": 102,
"cds_end": null,
"cds_length": 689,
"cdna_start": 290,
"cdna_end": null,
"cdna_length": 877,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000575129.5",
"protein_id": "ENSP00000460992.1",
"transcript_support_level": 2,
"aa_start": 34,
"aa_end": null,
"aa_length": 131,
"cds_start": 102,
"cds_end": null,
"cds_length": 396,
"cdna_start": 313,
"cdna_end": null,
"cdna_length": 607,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HMOX2",
"gene_hgnc_id": 5014,
"hgvs_c": "c.102G>A",
"hgvs_p": "p.Ser34Ser",
"transcript": "ENST00000576827.5",
"protein_id": "ENSP00000458824.1",
"transcript_support_level": 3,
"aa_start": 34,
"aa_end": null,
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}
],
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}