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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-4510928-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=4510928&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "16",
      "pos": 4510928,
      "ref": "G",
      "alt": "C",
      "effect": "3_prime_UTR_variant",
      "transcript": "NM_013399.3",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "NM_013399.3",
          "protein_id": "NP_037531.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000567695.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_013399.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000567695.6",
          "protein_id": "ENSP00000457877.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_013399.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000567695.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000399599.7",
          "protein_id": "ENSP00000382508.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000399599.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000563332.6",
          "protein_id": "ENSP00000454994.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000563332.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "NM_001199054.2",
          "protein_id": "NP_001185983.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001199054.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000857432.1",
          "protein_id": "ENSP00000527491.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000857432.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000857433.1",
          "protein_id": "ENSP00000527492.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000857433.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000857434.1",
          "protein_id": "ENSP00000527493.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000857434.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000857441.1",
          "protein_id": "ENSP00000527500.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 208,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 627,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000857441.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDIP1",
          "gene_hgnc_id": 13234,
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null,
          "transcript": "ENST00000857447.1",
          "protein_id": "ENSP00000527506.1",
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          "aa_start": null,
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          "aa_length": 208,
          "cds_start": null,
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          "cdna_start": null,
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          "mane_select": null,
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        },
        {
          "aa_ref": null,
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          "intron_rank": null,
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          "gene_symbol": "CDIP1",
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          "hgvs_c": "c.*1644C>G",
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          "protein_id": "ENSP00000527507.1",
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          "aa_start": null,
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          "cds_start": null,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
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          "consequences": [
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          "gene_symbol": "CDIP1",
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          "cds_start": null,
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        {
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          "gene_symbol": "CDIP1",
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        {
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          "intron_rank": null,
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          "gene_symbol": "CDIP1",
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        {
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        {
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          "gene_symbol": "CDIP1",
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        {
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          "gene_symbol": "CDIP1",
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        {
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        {
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          ],
          "exon_rank": 7,
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          "intron_rank": null,
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          "gene_symbol": "CDIP1",
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          "hgvs_c": "c.*1644C>G",
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          "transcript": "XM_047434044.1",
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          "feature": "XM_047434044.1"
        }
      ],
      "gene_symbol": "CDIP1",
      "gene_hgnc_id": 13234,
      "dbsnp": "rs7702",
      "frequency_reference_population": 0.7319865,
      "hom_count_reference_population": 41004,
      "allele_count_reference_population": 111382,
      "gnomad_exomes_af": 0.75,
      "gnomad_genomes_af": 0.731982,
      "gnomad_exomes_ac": 30,
      "gnomad_genomes_ac": 111352,
      "gnomad_exomes_homalt": 10,
      "gnomad_genomes_homalt": 40994,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.8999999761581421,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.9,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.221,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -12,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_by_gene": [
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "NM_013399.3",
          "gene_symbol": "CDIP1",
          "hgnc_id": 13234,
          "effects": [
            "3_prime_UTR_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.*1644C>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}