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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-56902407-CGT-TGC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=56902407&ref=CGT&alt=TGC&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PP2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "SLC12A3",
          "hgnc_id": 10912,
          "hgvs_c": "c.2782_2784delCGTinsTGC",
          "hgvs_p": "p.Arg928Cys",
          "inheritance_mode": "AR",
          "pathogenic_score": 1,
          "score": 1,
          "transcript": "NM_000339.3",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PP2",
      "acmg_score": 1,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "TGC",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "16",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1021,
          "aa_ref": "R",
          "aa_start": 919,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5540,
          "cdna_start": 2784,
          "cds_end": null,
          "cds_length": 3066,
          "cds_start": 2755,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001126108.2",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2755_2757delCGTinsTGC",
          "hgvs_p": "p.Arg919Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000563236.6",
          "protein_coding": true,
          "protein_id": "NP_001119580.2",
          "strand": true,
          "transcript": "NM_001126108.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1021,
          "aa_ref": "R",
          "aa_start": 919,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 5540,
          "cdna_start": 2784,
          "cds_end": null,
          "cds_length": 3066,
          "cds_start": 2755,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000563236.6",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2755_2757delCGTinsTGC",
          "hgvs_p": "p.Arg919Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001126108.2",
          "protein_coding": true,
          "protein_id": "ENSP00000456149.2",
          "strand": true,
          "transcript": "ENST00000563236.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1030,
          "aa_ref": "R",
          "aa_start": 928,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5567,
          "cdna_start": 2811,
          "cds_end": null,
          "cds_length": 3093,
          "cds_start": 2782,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000438926.6",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2782_2784delCGTinsTGC",
          "hgvs_p": "p.Arg928Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000402152.2",
          "strand": true,
          "transcript": "ENST00000438926.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1029,
          "aa_ref": "R",
          "aa_start": 927,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3119,
          "cdna_start": 2808,
          "cds_end": null,
          "cds_length": 3090,
          "cds_start": 2779,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000566786.5",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2779_2781delCGTinsTGC",
          "hgvs_p": "p.Arg927Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000457552.1",
          "strand": true,
          "transcript": "ENST00000566786.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1084,
          "aa_ref": "R",
          "aa_start": 918,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3434,
          "cdna_start": 2781,
          "cds_end": null,
          "cds_length": 3255,
          "cds_start": 2752,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898227.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2752_2754delCGTinsTGC",
          "hgvs_p": "p.Arg918Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568286.1",
          "strand": true,
          "transcript": "ENST00000898227.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1059,
          "aa_ref": "R",
          "aa_start": 957,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5652,
          "cdna_start": 2896,
          "cds_end": null,
          "cds_length": 3180,
          "cds_start": 2869,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898208.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2869_2871delCGTinsTGC",
          "hgvs_p": "p.Arg957Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568267.1",
          "strand": true,
          "transcript": "ENST00000898208.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1056,
          "aa_ref": "R",
          "aa_start": 954,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5645,
          "cdna_start": 2889,
          "cds_end": null,
          "cds_length": 3171,
          "cds_start": 2860,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898207.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2860_2862delCGTinsTGC",
          "hgvs_p": "p.Arg954Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568266.1",
          "strand": true,
          "transcript": "ENST00000898207.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1055,
          "aa_ref": "R",
          "aa_start": 953,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4315,
          "cdna_start": 2885,
          "cds_end": null,
          "cds_length": 3168,
          "cds_start": 2857,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898218.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2857_2859delCGTinsTGC",
          "hgvs_p": "p.Arg953Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568277.1",
          "strand": true,
          "transcript": "ENST00000898218.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1030,
          "aa_ref": "R",
          "aa_start": 928,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5567,
          "cdna_start": 2811,
          "cds_end": null,
          "cds_length": 3093,
          "cds_start": 2782,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_000339.3",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2782_2784delCGTinsTGC",
          "hgvs_p": "p.Arg928Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_000330.3",
          "strand": true,
          "transcript": "NM_000339.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1029,
          "aa_ref": "R",
          "aa_start": 927,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5564,
          "cdna_start": 2808,
          "cds_end": null,
          "cds_length": 3090,
          "cds_start": 2779,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001126107.2",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2779_2781delCGTinsTGC",
          "hgvs_p": "p.Arg927Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001119579.2",
          "strand": true,
          "transcript": "NM_001126107.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1026,
          "aa_ref": "R",
          "aa_start": 928,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4225,
          "cdna_start": 2809,
          "cds_end": null,
          "cds_length": 3081,
          "cds_start": 2782,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898221.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2782_2784delCGTinsTGC",
          "hgvs_p": "p.Arg928Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568280.1",
          "strand": true,
          "transcript": "ENST00000898221.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1020,
          "aa_ref": "R",
          "aa_start": 918,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5537,
          "cdna_start": 2781,
          "cds_end": null,
          "cds_length": 3063,
          "cds_start": 2752,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001410896.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2752_2754delCGTinsTGC",
          "hgvs_p": "p.Arg918Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001397825.1",
          "strand": true,
          "transcript": "NM_001410896.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1020,
          "aa_ref": "R",
          "aa_start": 918,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4208,
          "cdna_start": 2777,
          "cds_end": null,
          "cds_length": 3063,
          "cds_start": 2752,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000262502.5",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2752_2754delCGTinsTGC",
          "hgvs_p": "p.Arg918Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000262502.5",
          "strand": true,
          "transcript": "ENST00000262502.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1016,
          "aa_ref": "R",
          "aa_start": 918,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4196,
          "cdna_start": 2776,
          "cds_end": null,
          "cds_length": 3051,
          "cds_start": 2752,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898220.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2752_2754delCGTinsTGC",
          "hgvs_p": "p.Arg918Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568279.1",
          "strand": true,
          "transcript": "ENST00000898220.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1003,
          "aa_ref": "R",
          "aa_start": 901,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3656,
          "cdna_start": 2728,
          "cds_end": null,
          "cds_length": 3012,
          "cds_start": 2701,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898226.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2701_2703delCGTinsTGC",
          "hgvs_p": "p.Arg901Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568285.1",
          "strand": true,
          "transcript": "ENST00000898226.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 997,
          "aa_ref": "R",
          "aa_start": 895,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4140,
          "cdna_start": 2712,
          "cds_end": null,
          "cds_length": 2994,
          "cds_start": 2683,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898219.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2683_2685delCGTinsTGC",
          "hgvs_p": "p.Arg895Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568278.1",
          "strand": true,
          "transcript": "ENST00000898219.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 996,
          "aa_ref": "R",
          "aa_start": 894,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4139,
          "cdna_start": 2707,
          "cds_end": null,
          "cds_length": 2991,
          "cds_start": 2680,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898215.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2680_2682delCGTinsTGC",
          "hgvs_p": "p.Arg894Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568274.1",
          "strand": true,
          "transcript": "ENST00000898215.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 995,
          "aa_ref": "R",
          "aa_start": 893,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4136,
          "cdna_start": 2704,
          "cds_end": null,
          "cds_length": 2988,
          "cds_start": 2677,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000898213.1",
          "gene_hgnc_id": 10912,
          "gene_symbol": "SLC12A3",
          "hgvs_c": "c.2677_2679delCGTinsTGC",
          "hgvs_p": "p.Arg893Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568272.1",
          "strand": true,
          "transcript": "ENST00000898213.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 989,
          "aa_ref": "R",
          "aa_start": 887,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4118,
          "cdna_start": 2686,
          "cds_end": null,
          "cds_length": 2970,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.