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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-66908465-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=66908465&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 66908465,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_004062.4",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2417C>T",
"hgvs_p": "p.Thr806Ile",
"transcript": "NM_004062.4",
"protein_id": "NP_004053.1",
"transcript_support_level": null,
"aa_start": 806,
"aa_end": null,
"aa_length": 829,
"cds_start": 2417,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000299752.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004062.4"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2417C>T",
"hgvs_p": "p.Thr806Ile",
"transcript": "ENST00000299752.9",
"protein_id": "ENSP00000299752.4",
"transcript_support_level": 1,
"aa_start": 806,
"aa_end": null,
"aa_length": 829,
"cds_start": 2417,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004062.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000299752.9"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2351C>T",
"hgvs_p": "p.Thr784Ile",
"transcript": "ENST00000394055.7",
"protein_id": "ENSP00000377619.3",
"transcript_support_level": 1,
"aa_start": 784,
"aa_end": null,
"aa_length": 807,
"cds_start": 2351,
"cds_end": null,
"cds_length": 2424,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394055.7"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2126C>T",
"hgvs_p": "p.Thr709Ile",
"transcript": "ENST00000568632.5",
"protein_id": "ENSP00000455263.1",
"transcript_support_level": 1,
"aa_start": 709,
"aa_end": null,
"aa_length": 732,
"cds_start": 2126,
"cds_end": null,
"cds_length": 2199,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000568632.5"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2660C>T",
"hgvs_p": "p.Thr887Ile",
"transcript": "ENST00000867170.1",
"protein_id": "ENSP00000537229.1",
"transcript_support_level": null,
"aa_start": 887,
"aa_end": null,
"aa_length": 910,
"cds_start": 2660,
"cds_end": null,
"cds_length": 2733,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867170.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2450C>T",
"hgvs_p": "p.Thr817Ile",
"transcript": "ENST00000867174.1",
"protein_id": "ENSP00000537233.1",
"transcript_support_level": null,
"aa_start": 817,
"aa_end": null,
"aa_length": 840,
"cds_start": 2450,
"cds_end": null,
"cds_length": 2523,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867174.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2417C>T",
"hgvs_p": "p.Thr806Ile",
"transcript": "ENST00000867160.1",
"protein_id": "ENSP00000537219.1",
"transcript_support_level": null,
"aa_start": 806,
"aa_end": null,
"aa_length": 829,
"cds_start": 2417,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867160.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2417C>T",
"hgvs_p": "p.Thr806Ile",
"transcript": "ENST00000867165.1",
"protein_id": "ENSP00000537224.1",
"transcript_support_level": null,
"aa_start": 806,
"aa_end": null,
"aa_length": 829,
"cds_start": 2417,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867165.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2414C>T",
"hgvs_p": "p.Thr805Ile",
"transcript": "ENST00000867169.1",
"protein_id": "ENSP00000537228.1",
"transcript_support_level": null,
"aa_start": 805,
"aa_end": null,
"aa_length": 828,
"cds_start": 2414,
"cds_end": null,
"cds_length": 2487,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867169.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2414C>T",
"hgvs_p": "p.Thr805Ile",
"transcript": "ENST00000867180.1",
"protein_id": "ENSP00000537239.1",
"transcript_support_level": null,
"aa_start": 805,
"aa_end": null,
"aa_length": 828,
"cds_start": 2414,
"cds_end": null,
"cds_length": 2487,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867180.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2387C>T",
"hgvs_p": "p.Thr796Ile",
"transcript": "ENST00000867164.1",
"protein_id": "ENSP00000537223.1",
"transcript_support_level": null,
"aa_start": 796,
"aa_end": null,
"aa_length": 819,
"cds_start": 2387,
"cds_end": null,
"cds_length": 2460,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867164.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2387C>T",
"hgvs_p": "p.Thr796Ile",
"transcript": "ENST00000867178.1",
"protein_id": "ENSP00000537237.1",
"transcript_support_level": null,
"aa_start": 796,
"aa_end": null,
"aa_length": 819,
"cds_start": 2387,
"cds_end": null,
"cds_length": 2460,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867178.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2372C>T",
"hgvs_p": "p.Thr791Ile",
"transcript": "ENST00000867171.1",
"protein_id": "ENSP00000537230.1",
"transcript_support_level": null,
"aa_start": 791,
"aa_end": null,
"aa_length": 814,
"cds_start": 2372,
"cds_end": null,
"cds_length": 2445,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867171.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2351C>T",
"hgvs_p": "p.Thr784Ile",
"transcript": "NM_001204744.2",
"protein_id": "NP_001191673.1",
"transcript_support_level": null,
"aa_start": 784,
"aa_end": null,
"aa_length": 807,
"cds_start": 2351,
"cds_end": null,
"cds_length": 2424,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001204744.2"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2351C>T",
"hgvs_p": "p.Thr784Ile",
"transcript": "ENST00000867179.1",
"protein_id": "ENSP00000537238.1",
"transcript_support_level": null,
"aa_start": 784,
"aa_end": null,
"aa_length": 807,
"cds_start": 2351,
"cds_end": null,
"cds_length": 2424,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867179.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2336C>T",
"hgvs_p": "p.Thr779Ile",
"transcript": "ENST00000951240.1",
"protein_id": "ENSP00000621299.1",
"transcript_support_level": null,
"aa_start": 779,
"aa_end": null,
"aa_length": 802,
"cds_start": 2336,
"cds_end": null,
"cds_length": 2409,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951240.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2333C>T",
"hgvs_p": "p.Thr778Ile",
"transcript": "ENST00000867168.1",
"protein_id": "ENSP00000537227.1",
"transcript_support_level": null,
"aa_start": 778,
"aa_end": null,
"aa_length": 801,
"cds_start": 2333,
"cds_end": null,
"cds_length": 2406,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867168.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2300C>T",
"hgvs_p": "p.Thr767Ile",
"transcript": "NM_001204745.2",
"protein_id": "NP_001191674.1",
"transcript_support_level": null,
"aa_start": 767,
"aa_end": null,
"aa_length": 790,
"cds_start": 2300,
"cds_end": null,
"cds_length": 2373,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001204745.2"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2300C>T",
"hgvs_p": "p.Thr767Ile",
"transcript": "ENST00000565796.5",
"protein_id": "ENSP00000454784.1",
"transcript_support_level": 2,
"aa_start": 767,
"aa_end": null,
"aa_length": 790,
"cds_start": 2300,
"cds_end": null,
"cds_length": 2373,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000565796.5"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2300C>T",
"hgvs_p": "p.Thr767Ile",
"transcript": "ENST00000867163.1",
"protein_id": "ENSP00000537222.1",
"transcript_support_level": null,
"aa_start": 767,
"aa_end": null,
"aa_length": 790,
"cds_start": 2300,
"cds_end": null,
"cds_length": 2373,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867163.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2270C>T",
"hgvs_p": "p.Thr757Ile",
"transcript": "ENST00000867167.1",
"protein_id": "ENSP00000537226.1",
"transcript_support_level": null,
"aa_start": 757,
"aa_end": null,
"aa_length": 780,
"cds_start": 2270,
"cds_end": null,
"cds_length": 2343,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867167.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDH16",
"gene_hgnc_id": 1755,
"hgvs_c": "c.2270C>T",
"hgvs_p": "p.Thr757Ile",
"transcript": "ENST00000867176.1",
"protein_id": "ENSP00000537235.1",
"transcript_support_level": null,
"aa_start": 757,
"aa_end": null,
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