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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-670960-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=670960&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 670960,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000315082.9",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.708C>T",
"hgvs_p": "p.Asn236Asn",
"transcript": "NM_138769.3",
"protein_id": "NP_620124.1",
"transcript_support_level": null,
"aa_start": 236,
"aa_end": null,
"aa_length": 618,
"cds_start": 708,
"cds_end": null,
"cds_length": 1857,
"cdna_start": 776,
"cdna_end": null,
"cdna_length": 2490,
"mane_select": "ENST00000315082.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.708C>T",
"hgvs_p": "p.Asn236Asn",
"transcript": "ENST00000315082.9",
"protein_id": "ENSP00000321971.4",
"transcript_support_level": 1,
"aa_start": 236,
"aa_end": null,
"aa_length": 618,
"cds_start": 708,
"cds_end": null,
"cds_length": 1857,
"cdna_start": 776,
"cdna_end": null,
"cdna_length": 2490,
"mane_select": "NM_138769.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352287.1",
"protein_id": "NP_001339216.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352288.2",
"protein_id": "NP_001339217.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2550,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352289.2",
"protein_id": "NP_001339218.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2591,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352290.2",
"protein_id": "NP_001339219.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2572,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352291.2",
"protein_id": "NP_001339220.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2501,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352292.2",
"protein_id": "NP_001339221.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2555,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352293.2",
"protein_id": "NP_001339222.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.-38C>T",
"hgvs_p": null,
"transcript": "NM_001352294.2",
"protein_id": "NP_001339223.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": -4,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2473,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.711C>T",
"hgvs_p": "p.Asn237Asn",
"transcript": "NM_001352275.2",
"protein_id": "NP_001339204.1",
"transcript_support_level": null,
"aa_start": 237,
"aa_end": null,
"aa_length": 619,
"cds_start": 711,
"cds_end": null,
"cds_length": 1860,
"cdna_start": 779,
"cdna_end": null,
"cdna_length": 2493,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.711C>T",
"hgvs_p": "p.Asn237Asn",
"transcript": "ENST00000697194.1",
"protein_id": "ENSP00000513180.1",
"transcript_support_level": null,
"aa_start": 237,
"aa_end": null,
"aa_length": 619,
"cds_start": 711,
"cds_end": null,
"cds_length": 1860,
"cdna_start": 811,
"cdna_end": null,
"cdna_length": 2513,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.657C>T",
"hgvs_p": "p.Asn219Asn",
"transcript": "NM_001352276.2",
"protein_id": "NP_001339205.1",
"transcript_support_level": null,
"aa_start": 219,
"aa_end": null,
"aa_length": 601,
"cds_start": 657,
"cds_end": null,
"cds_length": 1806,
"cdna_start": 725,
"cdna_end": null,
"cdna_length": 2439,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.654C>T",
"hgvs_p": "p.Asn218Asn",
"transcript": "NM_001352277.2",
"protein_id": "NP_001339206.1",
"transcript_support_level": null,
"aa_start": 218,
"aa_end": null,
"aa_length": 600,
"cds_start": 654,
"cds_end": null,
"cds_length": 1803,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 2436,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asn203Asn",
"transcript": "NM_001352278.2",
"protein_id": "NP_001339207.1",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 585,
"cds_start": 609,
"cds_end": null,
"cds_length": 1758,
"cdna_start": 677,
"cdna_end": null,
"cdna_length": 2391,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.555C>T",
"hgvs_p": "p.Asn185Asn",
"transcript": "NM_001352279.2",
"protein_id": "NP_001339208.1",
"transcript_support_level": null,
"aa_start": 185,
"aa_end": null,
"aa_length": 567,
"cds_start": 555,
"cds_end": null,
"cds_length": 1704,
"cdna_start": 623,
"cdna_end": null,
"cdna_length": 2337,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.390C>T",
"hgvs_p": "p.Asn130Asn",
"transcript": "NM_001352280.2",
"protein_id": "NP_001339209.1",
"transcript_support_level": null,
"aa_start": 130,
"aa_end": null,
"aa_length": 512,
"cds_start": 390,
"cds_end": null,
"cds_length": 1539,
"cdna_start": 762,
"cdna_end": null,
"cdna_length": 2476,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.387C>T",
"hgvs_p": "p.Asn129Asn",
"transcript": "NM_001352281.2",
"protein_id": "NP_001339210.1",
"transcript_support_level": null,
"aa_start": 129,
"aa_end": null,
"aa_length": 511,
"cds_start": 387,
"cds_end": null,
"cds_length": 1536,
"cdna_start": 759,
"cdna_end": null,
"cdna_length": 2473,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.387C>T",
"hgvs_p": "p.Asn129Asn",
"transcript": "NM_001352282.2",
"protein_id": "NP_001339211.1",
"transcript_support_level": null,
"aa_start": 129,
"aa_end": null,
"aa_length": 511,
"cds_start": 387,
"cds_end": null,
"cds_length": 1536,
"cdna_start": 705,
"cdna_end": null,
"cdna_length": 2419,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.327C>T",
"hgvs_p": "p.Asn109Asn",
"transcript": "NM_001352283.2",
"protein_id": "NP_001339212.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 491,
"cds_start": 327,
"cds_end": null,
"cds_length": 1476,
"cdna_start": 771,
"cdna_end": null,
"cdna_length": 2485,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.291C>T",
"hgvs_p": "p.Asn97Asn",
"transcript": "NM_001352284.2",
"protein_id": "NP_001339213.1",
"transcript_support_level": null,
"aa_start": 97,
"aa_end": null,
"aa_length": 479,
"cds_start": 291,
"cds_end": null,
"cds_length": 1440,
"cdna_start": 663,
"cdna_end": null,
"cdna_length": 2377,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
"gene_hgnc_id": 21169,
"hgvs_c": "c.288C>T",
"hgvs_p": "p.Asn96Asn",
"transcript": "NM_001352285.2",
"protein_id": "NP_001339214.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 478,
"cds_start": 288,
"cds_end": null,
"cds_length": 1437,
"cdna_start": 660,
"cdna_end": null,
"cdna_length": 2374,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT2",
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}