← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-67230123-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=67230123&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "16",
      "pos": 67230123,
      "ref": "T",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_001318202.2",
      "consequences": [
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3157A>G",
          "hgvs_p": "p.Met1053Val",
          "transcript": "NM_013241.3",
          "protein_id": "NP_037373.2",
          "transcript_support_level": null,
          "aa_start": 1053,
          "aa_end": null,
          "aa_length": 1164,
          "cds_start": 3157,
          "cds_end": null,
          "cds_length": 3495,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000258201.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_013241.3"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3157A>G",
          "hgvs_p": "p.Met1053Val",
          "transcript": "ENST00000258201.9",
          "protein_id": "ENSP00000258201.4",
          "transcript_support_level": 1,
          "aa_start": 1053,
          "aa_end": null,
          "aa_length": 1164,
          "cds_start": 3157,
          "cds_end": null,
          "cds_length": 3495,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_013241.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000258201.9"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3439A>G",
          "hgvs_p": "p.Met1147Val",
          "transcript": "ENST00000932114.1",
          "protein_id": "ENSP00000602173.1",
          "transcript_support_level": null,
          "aa_start": 1147,
          "aa_end": null,
          "aa_length": 1258,
          "cds_start": 3439,
          "cds_end": null,
          "cds_length": 3777,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932114.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3427A>G",
          "hgvs_p": "p.Met1143Val",
          "transcript": "ENST00000910037.1",
          "protein_id": "ENSP00000580096.1",
          "transcript_support_level": null,
          "aa_start": 1143,
          "aa_end": null,
          "aa_length": 1254,
          "cds_start": 3427,
          "cds_end": null,
          "cds_length": 3765,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910037.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3262A>G",
          "hgvs_p": "p.Met1088Val",
          "transcript": "ENST00000910044.1",
          "protein_id": "ENSP00000580103.1",
          "transcript_support_level": null,
          "aa_start": 1088,
          "aa_end": null,
          "aa_length": 1199,
          "cds_start": 3262,
          "cds_end": null,
          "cds_length": 3600,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910044.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3235A>G",
          "hgvs_p": "p.Met1079Val",
          "transcript": "NM_001318202.2",
          "protein_id": "NP_001305131.1",
          "transcript_support_level": null,
          "aa_start": 1079,
          "aa_end": null,
          "aa_length": 1190,
          "cds_start": 3235,
          "cds_end": null,
          "cds_length": 3573,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001318202.2"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3235A>G",
          "hgvs_p": "p.Met1079Val",
          "transcript": "ENST00000910041.1",
          "protein_id": "ENSP00000580100.1",
          "transcript_support_level": null,
          "aa_start": 1079,
          "aa_end": null,
          "aa_length": 1190,
          "cds_start": 3235,
          "cds_end": null,
          "cds_length": 3573,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910041.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3211A>G",
          "hgvs_p": "p.Met1071Val",
          "transcript": "ENST00000910039.1",
          "protein_id": "ENSP00000580098.1",
          "transcript_support_level": null,
          "aa_start": 1071,
          "aa_end": null,
          "aa_length": 1182,
          "cds_start": 3211,
          "cds_end": null,
          "cds_length": 3549,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910039.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3235A>G",
          "hgvs_p": "p.Met1079Val",
          "transcript": "ENST00000966997.1",
          "protein_id": "ENSP00000637056.1",
          "transcript_support_level": null,
          "aa_start": 1079,
          "aa_end": null,
          "aa_length": 1178,
          "cds_start": 3235,
          "cds_end": null,
          "cds_length": 3537,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966997.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3184A>G",
          "hgvs_p": "p.Met1062Val",
          "transcript": "ENST00000910040.1",
          "protein_id": "ENSP00000580099.1",
          "transcript_support_level": null,
          "aa_start": 1062,
          "aa_end": null,
          "aa_length": 1173,
          "cds_start": 3184,
          "cds_end": null,
          "cds_length": 3522,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910040.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3154A>G",
          "hgvs_p": "p.Met1052Val",
          "transcript": "ENST00000932112.1",
          "protein_id": "ENSP00000602171.1",
          "transcript_support_level": null,
          "aa_start": 1052,
          "aa_end": null,
          "aa_length": 1163,
          "cds_start": 3154,
          "cds_end": null,
          "cds_length": 3492,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932112.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3127A>G",
          "hgvs_p": "p.Met1043Val",
          "transcript": "ENST00000910045.1",
          "protein_id": "ENSP00000580104.1",
          "transcript_support_level": null,
          "aa_start": 1043,
          "aa_end": null,
          "aa_length": 1154,
          "cds_start": 3127,
          "cds_end": null,
          "cds_length": 3465,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910045.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3157A>G",
          "hgvs_p": "p.Met1053Val",
          "transcript": "ENST00000910038.1",
          "protein_id": "ENSP00000580097.1",
          "transcript_support_level": null,
          "aa_start": 1053,
          "aa_end": null,
          "aa_length": 1152,
          "cds_start": 3157,
          "cds_end": null,
          "cds_length": 3459,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910038.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3049A>G",
          "hgvs_p": "p.Met1017Val",
          "transcript": "ENST00000910036.1",
          "protein_id": "ENSP00000580095.1",
          "transcript_support_level": null,
          "aa_start": 1017,
          "aa_end": null,
          "aa_length": 1128,
          "cds_start": 3049,
          "cds_end": null,
          "cds_length": 3387,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910036.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2995A>G",
          "hgvs_p": "p.Met999Val",
          "transcript": "ENST00000910035.1",
          "protein_id": "ENSP00000580094.1",
          "transcript_support_level": null,
          "aa_start": 999,
          "aa_end": null,
          "aa_length": 1110,
          "cds_start": 2995,
          "cds_end": null,
          "cds_length": 3333,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910035.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2974A>G",
          "hgvs_p": "p.Met992Val",
          "transcript": "ENST00000910042.1",
          "protein_id": "ENSP00000580101.1",
          "transcript_support_level": null,
          "aa_start": 992,
          "aa_end": null,
          "aa_length": 1103,
          "cds_start": 2974,
          "cds_end": null,
          "cds_length": 3312,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910042.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2842A>G",
          "hgvs_p": "p.Met948Val",
          "transcript": "ENST00000910043.1",
          "protein_id": "ENSP00000580102.1",
          "transcript_support_level": null,
          "aa_start": 948,
          "aa_end": null,
          "aa_length": 1059,
          "cds_start": 2842,
          "cds_end": null,
          "cds_length": 3180,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910043.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2788A>G",
          "hgvs_p": "p.Met930Val",
          "transcript": "ENST00000966998.1",
          "protein_id": "ENSP00000637057.1",
          "transcript_support_level": null,
          "aa_start": 930,
          "aa_end": null,
          "aa_length": 1041,
          "cds_start": 2788,
          "cds_end": null,
          "cds_length": 3126,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966998.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2752A>G",
          "hgvs_p": "p.Met918Val",
          "transcript": "ENST00000932113.1",
          "protein_id": "ENSP00000602172.1",
          "transcript_support_level": null,
          "aa_start": 918,
          "aa_end": null,
          "aa_length": 1029,
          "cds_start": 2752,
          "cds_end": null,
          "cds_length": 3090,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932113.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3205A>G",
          "hgvs_p": "p.Met1069Val",
          "transcript": "XM_011523043.3",
          "protein_id": "XP_011521345.1",
          "transcript_support_level": null,
          "aa_start": 1069,
          "aa_end": null,
          "aa_length": 1180,
          "cds_start": 3205,
          "cds_end": null,
          "cds_length": 3543,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011523043.3"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3127A>G",
          "hgvs_p": "p.Met1043Val",
          "transcript": "XM_047433999.1",
          "protein_id": "XP_047289955.1",
          "transcript_support_level": null,
          "aa_start": 1043,
          "aa_end": null,
          "aa_length": 1154,
          "cds_start": 3127,
          "cds_end": null,
          "cds_length": 3465,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047433999.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.3073A>G",
          "hgvs_p": "p.Met1025Val",
          "transcript": "XM_011523044.2",
          "protein_id": "XP_011521346.1",
          "transcript_support_level": null,
          "aa_start": 1025,
          "aa_end": null,
          "aa_length": 1136,
          "cds_start": 3073,
          "cds_end": null,
          "cds_length": 3411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011523044.2"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2995A>G",
          "hgvs_p": "p.Met999Val",
          "transcript": "XM_047434000.1",
          "protein_id": "XP_047289956.1",
          "transcript_support_level": null,
          "aa_start": 999,
          "aa_end": null,
          "aa_length": 1110,
          "cds_start": 2995,
          "cds_end": null,
          "cds_length": 3333,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047434000.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2878A>G",
          "hgvs_p": "p.Met960Val",
          "transcript": "XM_047434001.1",
          "protein_id": "XP_047289957.1",
          "transcript_support_level": null,
          "aa_start": 960,
          "aa_end": null,
          "aa_length": 1071,
          "cds_start": 2878,
          "cds_end": null,
          "cds_length": 3216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047434001.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2716A>G",
          "hgvs_p": "p.Met906Val",
          "transcript": "XM_047434002.1",
          "protein_id": "XP_047289958.1",
          "transcript_support_level": null,
          "aa_start": 906,
          "aa_end": null,
          "aa_length": 1017,
          "cds_start": 2716,
          "cds_end": null,
          "cds_length": 3054,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047434002.1"
        },
        {
          "aa_ref": "M",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "c.2596A>G",
          "hgvs_p": "p.Met866Val",
          "transcript": "XM_047434003.1",
          "protein_id": "XP_047289959.1",
          "transcript_support_level": null,
          "aa_start": 866,
          "aa_end": null,
          "aa_length": 977,
          "cds_start": 2596,
          "cds_end": null,
          "cds_length": 2934,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047434003.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "n.3738A>G",
          "hgvs_p": null,
          "transcript": "ENST00000567752.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000567752.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "n.74A>G",
          "hgvs_p": null,
          "transcript": "ENST00000569085.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000569085.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "n.*191A>G",
          "hgvs_p": null,
          "transcript": "ENST00000566006.1",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000566006.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FHOD1",
          "gene_hgnc_id": 17905,
          "hgvs_c": "n.*911A>G",
          "hgvs_p": null,
          "transcript": "ENST00000567561.1",
          "protein_id": "ENSP00000462807.1",
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000567561.1"
        }
      ],
      "gene_symbol": "FHOD1",
      "gene_hgnc_id": 17905,
      "dbsnp": "rs142647972",
      "frequency_reference_population": 0.00006752655,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 109,
      "gnomad_exomes_af": 0.0000355705,
      "gnomad_genomes_af": 0.000374276,
      "gnomad_exomes_ac": 52,
      "gnomad_genomes_ac": 57,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.033904969692230225,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.1,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.1918,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.19,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 4.213,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -4,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -4,
          "benign_score": 4,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_001318202.2",
          "gene_symbol": "FHOD1",
          "hgnc_id": 17905,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.3235A>G",
          "hgvs_p": "p.Met1079Val"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}