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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-69616361-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=69616361&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 69616361,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_138713.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.128-10042A>G",
"hgvs_p": null,
"transcript": "NM_138713.4",
"protein_id": "NP_619727.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1549,
"cds_start": null,
"cds_end": null,
"cds_length": 4650,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000349945.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_138713.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.128-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000349945.7",
"protein_id": "ENSP00000338806.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1549,
"cds_start": null,
"cds_end": null,
"cds_length": 4650,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_138713.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000349945.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.128-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000567239.5",
"protein_id": "ENSP00000457593.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1548,
"cds_start": null,
"cds_end": null,
"cds_length": 4647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000567239.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000354436.6",
"protein_id": "ENSP00000346420.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1531,
"cds_start": null,
"cds_end": null,
"cds_length": 4596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354436.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "n.74-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000393742.7",
"protein_id": "ENSP00000377343.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000393742.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "n.128-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000426654.6",
"protein_id": "ENSP00000413126.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000426654.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "n.23-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000566899.6",
"protein_id": "ENSP00000455628.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000566899.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.128-10042A>G",
"hgvs_p": null,
"transcript": "NM_001113178.3",
"protein_id": "NP_001106649.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1548,
"cds_start": null,
"cds_end": null,
"cds_length": 4647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001113178.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "NM_006599.4",
"protein_id": "NP_006590.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1531,
"cds_start": null,
"cds_end": null,
"cds_length": 4596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006599.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000896455.1",
"protein_id": "ENSP00000566514.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1530,
"cds_start": null,
"cds_end": null,
"cds_length": 4593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896455.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000957741.1",
"protein_id": "ENSP00000627800.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1525,
"cds_start": null,
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"cds_length": 4578,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957741.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.-217-10042A>G",
"hgvs_p": null,
"transcript": "NM_138714.4",
"protein_id": "NP_619728.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1455,
"cds_start": null,
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"cds_length": 4368,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_138714.4"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.-217-10042A>G",
"hgvs_p": null,
"transcript": "NM_173214.3",
"protein_id": "NP_775321.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1455,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173214.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
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"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.-217-10042A>G",
"hgvs_p": null,
"transcript": "NM_173215.3",
"protein_id": "NP_775322.1",
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_173215.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.-126-10042A>G",
"hgvs_p": null,
"transcript": "NM_001367709.1",
"protein_id": "NP_001354638.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1324,
"cds_start": null,
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"cds_length": 3975,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001367709.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000896456.1",
"protein_id": "ENSP00000566515.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000896456.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000917859.1",
"protein_id": "ENSP00000587918.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 712,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917859.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000917858.1",
"protein_id": "ENSP00000587917.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 650,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000917858.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 2,
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"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.128-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000896457.1",
"protein_id": "ENSP00000566516.1",
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"feature": "ENST00000896457.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.29-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000565301.2",
"protein_id": "ENSP00000463214.2",
"transcript_support_level": 2,
"aa_start": null,
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"feature": "ENST00000565301.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "c.74-10042A>G",
"hgvs_p": null,
"transcript": "XM_011522817.4",
"protein_id": "XP_011521119.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1530,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011522817.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NFAT5",
"gene_hgnc_id": 7774,
"hgvs_c": "n.128-10042A>G",
"hgvs_p": null,
"transcript": "ENST00000567990.5",
"protein_id": "ENSP00000455115.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000567990.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
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{
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}
],
"message": null
}