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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-70333562-ATT-CTA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=70333562&ref=ATT&alt=CTA&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "DDX19B",
          "hgnc_id": 2742,
          "hgvs_c": "c.1435_1437delATTinsCTA",
          "hgvs_p": "p.Ile479Leu",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_001363938.1",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ENSG00000260537",
          "hgnc_id": null,
          "hgvs_c": "c.160+18607_160+18609delATTinsCTA",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "ENST00000443119.7",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "DDX19A-DT",
          "hgnc_id": 55349,
          "hgvs_c": "n.850+256_850+258delAATinsTAG",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "ENST00000562077.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "CTA",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "16",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 479,
          "aa_ref": "I",
          "aa_start": 474,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3275,
          "cdna_start": 1532,
          "cds_end": null,
          "cds_length": 1440,
          "cds_start": 1420,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_007242.7",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1420_1422delATTinsCTA",
          "hgvs_p": "p.Ile474Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000288071.11",
          "protein_coding": true,
          "protein_id": "NP_009173.1",
          "strand": true,
          "transcript": "NM_007242.7",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 479,
          "aa_ref": "I",
          "aa_start": 474,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3275,
          "cdna_start": 1532,
          "cds_end": null,
          "cds_length": 1440,
          "cds_start": 1420,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000288071.11",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1420_1422delATTinsCTA",
          "hgvs_p": "p.Ile474Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_007242.7",
          "protein_coding": true,
          "protein_id": "ENSP00000288071.7",
          "strand": true,
          "transcript": "ENST00000288071.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 448,
          "aa_ref": "I",
          "aa_start": 443,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1692,
          "cdna_start": 1431,
          "cds_end": null,
          "cds_length": 1347,
          "cds_start": 1327,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000355992.7",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1327_1329delATTinsCTA",
          "hgvs_p": "p.Ile443Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000348271.3",
          "strand": true,
          "transcript": "ENST00000355992.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 370,
          "aa_ref": "I",
          "aa_start": 365,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1717,
          "cdna_start": 1453,
          "cds_end": null,
          "cds_length": 1113,
          "cds_start": 1093,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000393657.6",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1093_1095delATTinsCTA",
          "hgvs_p": "p.Ile365Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000377267.2",
          "strand": true,
          "transcript": "ENST00000393657.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 370,
          "aa_ref": "I",
          "aa_start": 365,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1760,
          "cdna_start": 1502,
          "cds_end": null,
          "cds_length": 1113,
          "cds_start": 1093,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000563392.5",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1093_1095delATTinsCTA",
          "hgvs_p": "p.Ile365Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000456574.1",
          "strand": true,
          "transcript": "ENST00000563392.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 479,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2110,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1440,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000443119.7",
          "gene_hgnc_id": null,
          "gene_symbol": "ENSG00000260537",
          "hgvs_c": "c.160+18607_160+18609delATTinsCTA",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000399208.3",
          "strand": true,
          "transcript": "ENST00000443119.7",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1471,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000562077.5",
          "gene_hgnc_id": 55349,
          "gene_symbol": "DDX19A-DT",
          "hgvs_c": "n.850+256_850+258delAATinsTAG",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000562077.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 484,
          "aa_ref": "I",
          "aa_start": 479,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3222,
          "cdna_start": 1504,
          "cds_end": null,
          "cds_length": 1455,
          "cds_start": 1435,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001363938.1",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1435_1437delATTinsCTA",
          "hgvs_p": "p.Ile479Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001350867.1",
          "strand": true,
          "transcript": "NM_001363938.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 484,
          "aa_ref": "I",
          "aa_start": 479,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1765,
          "cdna_start": 1504,
          "cds_end": null,
          "cds_length": 1455,
          "cds_start": 1435,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000563206.5",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1435_1437delATTinsCTA",
          "hgvs_p": "p.Ile479Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000455813.1",
          "strand": true,
          "transcript": "ENST00000563206.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 484,
          "aa_ref": "I",
          "aa_start": 479,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1805,
          "cdna_start": 1545,
          "cds_end": null,
          "cds_length": 1455,
          "cds_start": 1435,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872522.1",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1435_1437delATTinsCTA",
          "hgvs_p": "p.Ile479Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542581.1",
          "strand": true,
          "transcript": "ENST00000872522.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 479,
          "aa_ref": "I",
          "aa_start": 474,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3386,
          "cdna_start": 1652,
          "cds_end": null,
          "cds_length": 1440,
          "cds_start": 1420,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000912196.1",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1420_1422delATTinsCTA",
          "hgvs_p": "p.Ile474Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000582255.1",
          "strand": true,
          "transcript": "ENST00000912196.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 479,
          "aa_ref": "I",
          "aa_start": 474,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2057,
          "cdna_start": 1796,
          "cds_end": null,
          "cds_length": 1440,
          "cds_start": 1420,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000912197.1",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1420_1422delATTinsCTA",
          "hgvs_p": "p.Ile474Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000582256.1",
          "strand": true,
          "transcript": "ENST00000912197.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 453,
          "aa_ref": "I",
          "aa_start": 448,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3129,
          "cdna_start": 1411,
          "cds_end": null,
          "cds_length": 1362,
          "cds_start": 1342,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001257172.2",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1342_1344delATTinsCTA",
          "hgvs_p": "p.Ile448Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001244101.1",
          "strand": true,
          "transcript": "NM_001257172.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 453,
          "aa_ref": "I",
          "aa_start": 448,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1608,
          "cdna_start": 1391,
          "cds_end": null,
          "cds_length": 1362,
          "cds_start": 1342,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000451014.7",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1342_1344delATTinsCTA",
          "hgvs_p": "p.Ile448Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000392639.3",
          "strand": true,
          "transcript": "ENST00000451014.7",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 448,
          "aa_ref": "I",
          "aa_start": 443,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3290,
          "cdna_start": 1572,
          "cds_end": null,
          "cds_length": 1347,
          "cds_start": 1327,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001014451.3",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1327_1329delATTinsCTA",
          "hgvs_p": "p.Ile443Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001014451.1",
          "strand": true,
          "transcript": "NM_001014451.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 430,
          "aa_ref": "I",
          "aa_start": 425,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1672,
          "cdna_start": 1406,
          "cds_end": null,
          "cds_length": 1293,
          "cds_start": 1273,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872520.1",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1273_1275delATTinsCTA",
          "hgvs_p": "p.Ile425Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542579.1",
          "strand": true,
          "transcript": "ENST00000872520.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 426,
          "aa_ref": "I",
          "aa_start": 421,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1647,
          "cdna_start": 1371,
          "cds_end": null,
          "cds_length": 1281,
          "cds_start": 1261,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000872521.1",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1261_1263delATTinsCTA",
          "hgvs_p": "p.Ile421Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000542580.1",
          "strand": true,
          "transcript": "ENST00000872521.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 370,
          "aa_ref": "I",
          "aa_start": 365,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3280,
          "cdna_start": 1562,
          "cds_end": null,
          "cds_length": 1113,
          "cds_start": 1093,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001014449.3",
          "gene_hgnc_id": 2742,
          "gene_symbol": "DDX19B",
          "hgvs_c": "c.1093_1095delATTinsCTA",
          "hgvs_p": "p.Ile365Leu",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.