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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-71449594-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=71449594&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 71449594,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000647773.2",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.560G>T",
"hgvs_p": "p.Gly187Val",
"transcript": "NM_001381984.1",
"protein_id": "NP_001368913.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 686,
"cds_start": 560,
"cds_end": null,
"cds_length": 2061,
"cdna_start": 630,
"cdna_end": null,
"cdna_length": 2627,
"mane_select": "ENST00000647773.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.560G>T",
"hgvs_p": "p.Gly187Val",
"transcript": "ENST00000647773.2",
"protein_id": "ENSP00000497736.2",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 686,
"cds_start": 560,
"cds_end": null,
"cds_length": 2061,
"cdna_start": 630,
"cdna_end": null,
"cdna_length": 2627,
"mane_select": "NM_001381984.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.431G>T",
"hgvs_p": "p.Gly144Val",
"transcript": "ENST00000393539.6",
"protein_id": "ENSP00000377171.2",
"transcript_support_level": 1,
"aa_start": 144,
"aa_end": null,
"aa_length": 643,
"cds_start": 431,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 3242,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.431G>T",
"hgvs_p": "p.Gly144Val",
"transcript": "ENST00000428724.5",
"protein_id": "ENSP00000387673.3",
"transcript_support_level": 1,
"aa_start": 144,
"aa_end": null,
"aa_length": 643,
"cds_start": 431,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 431,
"cdna_end": null,
"cdna_length": 1932,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000261611",
"gene_hgnc_id": null,
"hgvs_c": "n.*895G>T",
"hgvs_p": null,
"transcript": "ENST00000561908.1",
"protein_id": "ENSP00000463741.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3677,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000261611",
"gene_hgnc_id": null,
"hgvs_c": "n.*895G>T",
"hgvs_p": null,
"transcript": "ENST00000561908.1",
"protein_id": "ENSP00000463741.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3677,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.548G>T",
"hgvs_p": "p.Gly183Val",
"transcript": "NM_001381973.1",
"protein_id": "NP_001368902.1",
"transcript_support_level": null,
"aa_start": 183,
"aa_end": null,
"aa_length": 682,
"cds_start": 548,
"cds_end": null,
"cds_length": 2049,
"cdna_start": 1247,
"cdna_end": null,
"cdna_length": 3244,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.548G>T",
"hgvs_p": "p.Gly183Val",
"transcript": "NM_001381974.1",
"protein_id": "NP_001368903.1",
"transcript_support_level": null,
"aa_start": 183,
"aa_end": null,
"aa_length": 682,
"cds_start": 548,
"cds_end": null,
"cds_length": 2049,
"cdna_start": 1231,
"cdna_end": null,
"cdna_length": 3228,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.545G>T",
"hgvs_p": "p.Gly182Val",
"transcript": "NM_001381980.1",
"protein_id": "NP_001368909.1",
"transcript_support_level": null,
"aa_start": 182,
"aa_end": null,
"aa_length": 681,
"cds_start": 545,
"cds_end": null,
"cds_length": 2046,
"cdna_start": 1228,
"cdna_end": null,
"cdna_length": 3225,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.443G>T",
"hgvs_p": "p.Gly148Val",
"transcript": "NM_001381981.1",
"protein_id": "NP_001368910.1",
"transcript_support_level": null,
"aa_start": 148,
"aa_end": null,
"aa_length": 647,
"cds_start": 443,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 689,
"cdna_end": null,
"cdna_length": 2686,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.434G>T",
"hgvs_p": "p.Gly145Val",
"transcript": "NM_001381975.1",
"protein_id": "NP_001368904.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 644,
"cds_start": 434,
"cds_end": null,
"cds_length": 1935,
"cdna_start": 1247,
"cdna_end": null,
"cdna_length": 3244,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.434G>T",
"hgvs_p": "p.Gly145Val",
"transcript": "NM_001381976.1",
"protein_id": "NP_001368905.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 644,
"cds_start": 434,
"cds_end": null,
"cds_length": 1935,
"cdna_start": 1315,
"cdna_end": null,
"cdna_length": 3312,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.434G>T",
"hgvs_p": "p.Gly145Val",
"transcript": "NM_001381977.1",
"protein_id": "NP_001368906.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 644,
"cds_start": 434,
"cds_end": null,
"cds_length": 1935,
"cdna_start": 1346,
"cdna_end": null,
"cdna_length": 3343,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.434G>T",
"hgvs_p": "p.Gly145Val",
"transcript": "NM_001381978.1",
"protein_id": "NP_001368907.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 644,
"cds_start": 434,
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"cdna_start": 1251,
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"cdna_length": 3248,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.434G>T",
"hgvs_p": "p.Gly145Val",
"transcript": "NM_001381979.1",
"protein_id": "NP_001368908.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 644,
"cds_start": 434,
"cds_end": null,
"cds_length": 1935,
"cdna_start": 1083,
"cdna_end": null,
"cdna_length": 3080,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.431G>T",
"hgvs_p": "p.Gly144Val",
"transcript": "NM_001304492.2",
"protein_id": "NP_001291421.1",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 643,
"cds_start": 431,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 677,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.431G>T",
"hgvs_p": "p.Gly144Val",
"transcript": "NM_001381965.1",
"protein_id": "NP_001368894.1",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 643,
"cds_start": 431,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 1343,
"cdna_end": null,
"cdna_length": 3340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.431G>T",
"hgvs_p": "p.Gly144Val",
"transcript": "NM_001381966.1",
"protein_id": "NP_001368895.1",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 643,
"cds_start": 431,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 1228,
"cdna_end": null,
"cdna_length": 3225,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.431G>T",
"hgvs_p": "p.Gly144Val",
"transcript": "NM_145911.3",
"protein_id": "NP_666016.1",
"transcript_support_level": null,
"aa_start": 144,
"aa_end": null,
"aa_length": 643,
"cds_start": 431,
"cds_end": null,
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"cdna_start": 1278,
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"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.431G>T",
"hgvs_p": "p.Gly144Val",
"transcript": "ENST00000357254.8",
"protein_id": "ENSP00000349796.4",
"transcript_support_level": 2,
"aa_start": 144,
"aa_end": null,
"aa_length": 643,
"cds_start": 431,
"cds_end": null,
"cds_length": 1932,
"cdna_start": 1189,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.257G>T",
"hgvs_p": "p.Gly86Val",
"transcript": "NM_001304493.2",
"protein_id": "NP_001291422.1",
"transcript_support_level": null,
"aa_start": 86,
"aa_end": null,
"aa_length": 585,
"cds_start": 257,
"cds_end": null,
"cds_length": 1758,
"cdna_start": 802,
"cdna_end": null,
"cdna_length": 2799,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.257G>T",
"hgvs_p": "p.Gly86Val",
"transcript": "NM_001304494.2",
"protein_id": "NP_001291423.1",
"transcript_support_level": null,
"aa_start": 86,
"aa_end": null,
"aa_length": 585,
"cds_start": 257,
"cds_end": null,
"cds_length": 1758,
"cdna_start": 395,
"cdna_end": null,
"cdna_length": 2392,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF23",
"gene_hgnc_id": 13023,
"hgvs_c": "c.257G>T",
"hgvs_p": "p.Gly86Val",
"transcript": "NM_001381967.1",
"protein_id": "NP_001368896.1",
"transcript_support_level": null,
"aa_start": 86,
"aa_end": null,
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}