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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-75248066-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=75248066&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 75248066,
"ref": "A",
"alt": "T",
"effect": "5_prime_UTR_variant",
"transcript": "NM_001170719.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "NM_014567.5",
"protein_id": "NP_055382.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 870,
"cds_start": null,
"cds_end": null,
"cds_length": 2613,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000162330.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014567.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "ENST00000162330.10",
"protein_id": "ENSP00000162330.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 870,
"cds_start": null,
"cds_end": null,
"cds_length": 2613,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_014567.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000162330.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.-7T>A",
"hgvs_p": null,
"transcript": "NM_001170719.3",
"protein_id": "NP_001164190.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 868,
"cds_start": null,
"cds_end": null,
"cds_length": 2607,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001170719.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.-7T>A",
"hgvs_p": null,
"transcript": "ENST00000542031.6",
"protein_id": "ENSP00000440415.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 868,
"cds_start": null,
"cds_end": null,
"cds_length": 2607,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000542031.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.151-4976T>A",
"hgvs_p": null,
"transcript": "NM_001170714.3",
"protein_id": "NP_001164185.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 916,
"cds_start": null,
"cds_end": null,
"cds_length": 2751,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001170714.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.151-4976T>A",
"hgvs_p": null,
"transcript": "ENST00000418647.7",
"protein_id": "ENSP00000391669.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 916,
"cds_start": null,
"cds_end": null,
"cds_length": 2751,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000418647.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "ENST00000853597.1",
"protein_id": "ENSP00000523656.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 891,
"cds_start": null,
"cds_end": null,
"cds_length": 2676,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853597.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.67-4976T>A",
"hgvs_p": null,
"transcript": "NM_001170715.3",
"protein_id": "NP_001164186.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 888,
"cds_start": null,
"cds_end": null,
"cds_length": 2667,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001170715.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.67-4976T>A",
"hgvs_p": null,
"transcript": "NM_001170716.3",
"protein_id": "NP_001164187.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 888,
"cds_start": null,
"cds_end": null,
"cds_length": 2667,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001170716.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "NM_001170717.3",
"protein_id": "NP_001164188.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 888,
"cds_start": null,
"cds_end": null,
"cds_length": 2667,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001170717.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "ENST00000393420.10",
"protein_id": "ENSP00000377072.6",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 888,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393420.10"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.67-4976T>A",
"hgvs_p": null,
"transcript": "ENST00000393422.6",
"protein_id": "ENSP00000377074.2",
"transcript_support_level": 2,
"aa_start": null,
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"aa_length": 888,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000393422.6"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.67-4976T>A",
"hgvs_p": null,
"transcript": "ENST00000420641.7",
"protein_id": "ENSP00000392708.3",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000420641.7"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.13-4976T>A",
"hgvs_p": null,
"transcript": "NM_001170718.3",
"protein_id": "NP_001164189.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001170718.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.13-4976T>A",
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"transcript": "ENST00000538440.6",
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"biotype": "protein_coding",
"feature": "ENST00000538440.6"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "ENST00000928349.1",
"protein_id": "ENSP00000598408.1",
"transcript_support_level": null,
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"cds_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000928349.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "ENST00000942295.1",
"protein_id": "ENSP00000612354.1",
"transcript_support_level": null,
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"cds_start": null,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "ENST00000942294.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+3405T>A",
"hgvs_p": null,
"transcript": "ENST00000853596.1",
"protein_id": "ENSP00000523655.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+4169T>A",
"hgvs_p": null,
"transcript": "NM_001170720.3",
"protein_id": "NP_001164191.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001170720.3"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "BCAR1",
"gene_hgnc_id": 971,
"hgvs_c": "c.12+4169T>A",
"hgvs_p": null,
"transcript": "ENST00000535626.6",
"protein_id": "ENSP00000440370.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 722,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000535626.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
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}
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}