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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-84459372-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=84459372&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 84459372,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001286527.3",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2319G>C",
"hgvs_p": "p.Gly773Gly",
"transcript": "NM_014861.4",
"protein_id": "NP_055676.3",
"transcript_support_level": null,
"aa_start": 773,
"aa_end": null,
"aa_length": 946,
"cds_start": 2319,
"cds_end": null,
"cds_length": 2841,
"cdna_start": 2397,
"cdna_end": null,
"cdna_length": 3374,
"mane_select": "ENST00000262429.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014861.4"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2319G>C",
"hgvs_p": "p.Gly773Gly",
"transcript": "ENST00000262429.9",
"protein_id": "ENSP00000262429.4",
"transcript_support_level": 1,
"aa_start": 773,
"aa_end": null,
"aa_length": 946,
"cds_start": 2319,
"cds_end": null,
"cds_length": 2841,
"cdna_start": 2397,
"cdna_end": null,
"cdna_length": 3374,
"mane_select": "NM_014861.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000262429.9"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2319G>C",
"hgvs_p": "p.Gly773Gly",
"transcript": "ENST00000416219.7",
"protein_id": "ENSP00000397925.2",
"transcript_support_level": 1,
"aa_start": 773,
"aa_end": null,
"aa_length": 975,
"cds_start": 2319,
"cds_end": null,
"cds_length": 2928,
"cdna_start": 2408,
"cdna_end": null,
"cdna_length": 5064,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000416219.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2-AS1",
"gene_hgnc_id": 53167,
"hgvs_c": "n.2885C>G",
"hgvs_p": null,
"transcript": "ENST00000565700.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2998,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000565700.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2319G>C",
"hgvs_p": "p.Gly773Gly",
"transcript": "NM_001286527.3",
"protein_id": "NP_001273456.2",
"transcript_support_level": null,
"aa_start": 773,
"aa_end": null,
"aa_length": 975,
"cds_start": 2319,
"cds_end": null,
"cds_length": 2928,
"cdna_start": 2397,
"cdna_end": null,
"cdna_length": 3461,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286527.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2394G>C",
"hgvs_p": "p.Gly798Gly",
"transcript": "ENST00000861763.1",
"protein_id": "ENSP00000531822.1",
"transcript_support_level": null,
"aa_start": 798,
"aa_end": null,
"aa_length": 971,
"cds_start": 2394,
"cds_end": null,
"cds_length": 2916,
"cdna_start": 2483,
"cdna_end": null,
"cdna_length": 3737,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861763.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2394G>C",
"hgvs_p": "p.Gly798Gly",
"transcript": "ENST00000861768.1",
"protein_id": "ENSP00000531827.1",
"transcript_support_level": null,
"aa_start": 798,
"aa_end": null,
"aa_length": 971,
"cds_start": 2394,
"cds_end": null,
"cds_length": 2916,
"cdna_start": 2434,
"cdna_end": null,
"cdna_length": 3408,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861768.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2337G>C",
"hgvs_p": "p.Gly779Gly",
"transcript": "ENST00000861767.1",
"protein_id": "ENSP00000531826.1",
"transcript_support_level": null,
"aa_start": 779,
"aa_end": null,
"aa_length": 952,
"cds_start": 2337,
"cds_end": null,
"cds_length": 2859,
"cdna_start": 2426,
"cdna_end": null,
"cdna_length": 3394,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861767.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2313G>C",
"hgvs_p": "p.Gly771Gly",
"transcript": "ENST00000861766.1",
"protein_id": "ENSP00000531825.1",
"transcript_support_level": null,
"aa_start": 771,
"aa_end": null,
"aa_length": 944,
"cds_start": 2313,
"cds_end": null,
"cds_length": 2835,
"cdna_start": 2402,
"cdna_end": null,
"cdna_length": 3372,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861766.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2313G>C",
"hgvs_p": "p.Gly771Gly",
"transcript": "ENST00000957789.1",
"protein_id": "ENSP00000627848.1",
"transcript_support_level": null,
"aa_start": 771,
"aa_end": null,
"aa_length": 944,
"cds_start": 2313,
"cds_end": null,
"cds_length": 2835,
"cdna_start": 2393,
"cdna_end": null,
"cdna_length": 3185,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957789.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2310G>C",
"hgvs_p": "p.Gly770Gly",
"transcript": "ENST00000861764.1",
"protein_id": "ENSP00000531823.1",
"transcript_support_level": null,
"aa_start": 770,
"aa_end": null,
"aa_length": 943,
"cds_start": 2310,
"cds_end": null,
"cds_length": 2832,
"cdna_start": 2431,
"cdna_end": null,
"cdna_length": 3405,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861764.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2307G>C",
"hgvs_p": "p.Gly769Gly",
"transcript": "ENST00000861771.1",
"protein_id": "ENSP00000531830.1",
"transcript_support_level": null,
"aa_start": 769,
"aa_end": null,
"aa_length": 942,
"cds_start": 2307,
"cds_end": null,
"cds_length": 2829,
"cdna_start": 2385,
"cdna_end": null,
"cdna_length": 3174,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861771.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2217G>C",
"hgvs_p": "p.Gly739Gly",
"transcript": "ENST00000957791.1",
"protein_id": "ENSP00000627850.1",
"transcript_support_level": null,
"aa_start": 739,
"aa_end": null,
"aa_length": 941,
"cds_start": 2217,
"cds_end": null,
"cds_length": 2826,
"cdna_start": 2296,
"cdna_end": null,
"cdna_length": 3171,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957791.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2217G>C",
"hgvs_p": "p.Gly739Gly",
"transcript": "ENST00000861762.1",
"protein_id": "ENSP00000531821.1",
"transcript_support_level": null,
"aa_start": 739,
"aa_end": null,
"aa_length": 912,
"cds_start": 2217,
"cds_end": null,
"cds_length": 2739,
"cdna_start": 2357,
"cdna_end": null,
"cdna_length": 3611,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861762.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2208G>C",
"hgvs_p": "p.Gly736Gly",
"transcript": "ENST00000957790.1",
"protein_id": "ENSP00000627849.1",
"transcript_support_level": null,
"aa_start": 736,
"aa_end": null,
"aa_length": 909,
"cds_start": 2208,
"cds_end": null,
"cds_length": 2730,
"cdna_start": 2290,
"cdna_end": null,
"cdna_length": 3079,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957790.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2148G>C",
"hgvs_p": "p.Gly716Gly",
"transcript": "ENST00000861770.1",
"protein_id": "ENSP00000531829.1",
"transcript_support_level": null,
"aa_start": 716,
"aa_end": null,
"aa_length": 889,
"cds_start": 2148,
"cds_end": null,
"cds_length": 2670,
"cdna_start": 2237,
"cdna_end": null,
"cdna_length": 3029,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861770.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2100G>C",
"hgvs_p": "p.Gly700Gly",
"transcript": "ENST00000861765.1",
"protein_id": "ENSP00000531824.1",
"transcript_support_level": null,
"aa_start": 700,
"aa_end": null,
"aa_length": 873,
"cds_start": 2100,
"cds_end": null,
"cds_length": 2622,
"cdna_start": 2189,
"cdna_end": null,
"cdna_length": 3165,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861765.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.1866G>C",
"hgvs_p": "p.Gly622Gly",
"transcript": "NM_001291454.2",
"protein_id": "NP_001278383.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 795,
"cds_start": 1866,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 1992,
"cdna_end": null,
"cdna_length": 2969,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001291454.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2250G>C",
"hgvs_p": "p.Gly750Gly",
"transcript": "XM_011523486.3",
"protein_id": "XP_011521788.1",
"transcript_support_level": null,
"aa_start": 750,
"aa_end": null,
"aa_length": 952,
"cds_start": 2250,
"cds_end": null,
"cds_length": 2859,
"cdna_start": 2500,
"cdna_end": null,
"cdna_length": 3564,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011523486.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2250G>C",
"hgvs_p": "p.Gly750Gly",
"transcript": "XM_047434994.1",
"protein_id": "XP_047290950.1",
"transcript_support_level": null,
"aa_start": 750,
"aa_end": null,
"aa_length": 923,
"cds_start": 2250,
"cds_end": null,
"cds_length": 2772,
"cdna_start": 2495,
"cdna_end": null,
"cdna_length": 3472,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047434994.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.1290G>C",
"hgvs_p": "p.Gly430Gly",
"transcript": "XM_011523487.3",
"protein_id": "XP_011521789.1",
"transcript_support_level": null,
"aa_start": 430,
"aa_end": null,
"aa_length": 632,
"cds_start": 1290,
"cds_end": null,
"cds_length": 1899,
"cdna_start": 1544,
"cdna_end": null,
"cdna_length": 2608,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011523487.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "ATP2C2",
"gene_hgnc_id": 29103,
"hgvs_c": "c.2216+184G>C",
"hgvs_p": null,
"transcript": "ENST00000861769.1",
"protein_id": "ENSP00000531828.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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{
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],
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"computational_prediction_selected": "Benign",
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"splice_prediction_selected": "Benign",
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"bayesdelnoaf_score": -0.47,
"bayesdelnoaf_prediction": "Benign",
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"phylop100way_prediction": "Benign",
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"spliceai_max_prediction": "Benign",
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{
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"PM2",
"BP4_Strong"
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"verdict": "Likely_benign",
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"effects": [
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{
"score": -2,
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"BP4_Strong"
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"verdict": "Likely_benign",
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],
"clinvar_disease": "",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}