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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-86532418-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=86532418&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 86532418,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001159377.2",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.745G>T",
"hgvs_p": "p.Ala249Ser",
"transcript": "NM_001159377.2",
"protein_id": "NP_001152849.1",
"transcript_support_level": null,
"aa_start": 249,
"aa_end": null,
"aa_length": 383,
"cds_start": 745,
"cds_end": null,
"cds_length": 1152,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000360900.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001159377.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.745G>T",
"hgvs_p": "p.Ala249Ser",
"transcript": "ENST00000360900.11",
"protein_id": "ENSP00000354152.6",
"transcript_support_level": 1,
"aa_start": 249,
"aa_end": null,
"aa_length": 383,
"cds_start": 745,
"cds_end": null,
"cds_length": 1152,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001159377.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360900.11"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.745G>T",
"hgvs_p": "p.Ala249Ser",
"transcript": "ENST00000381214.9",
"protein_id": "ENSP00000370612.5",
"transcript_support_level": 1,
"aa_start": 249,
"aa_end": null,
"aa_length": 383,
"cds_start": 745,
"cds_end": null,
"cds_length": 1152,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381214.9"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.742G>T",
"hgvs_p": "p.Ala248Ser",
"transcript": "ENST00000543303.6",
"protein_id": "ENSP00000444003.2",
"transcript_support_level": 1,
"aa_start": 248,
"aa_end": null,
"aa_length": 382,
"cds_start": 742,
"cds_end": null,
"cds_length": 1149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000543303.6"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.742G>T",
"hgvs_p": "p.Ala248Ser",
"transcript": "ENST00000634347.1",
"protein_id": "ENSP00000489295.1",
"transcript_support_level": 1,
"aa_start": 248,
"aa_end": null,
"aa_length": 382,
"cds_start": 742,
"cds_end": null,
"cds_length": 1149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000634347.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "n.*550G>T",
"hgvs_p": null,
"transcript": "ENST00000566050.5",
"protein_id": "ENSP00000456910.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000566050.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "n.*550G>T",
"hgvs_p": null,
"transcript": "ENST00000566050.5",
"protein_id": "ENSP00000456910.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000566050.5"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.745G>T",
"hgvs_p": "p.Ala249Ser",
"transcript": "NM_001159378.2",
"protein_id": "NP_001152850.1",
"transcript_support_level": null,
"aa_start": 249,
"aa_end": null,
"aa_length": 383,
"cds_start": 745,
"cds_end": null,
"cds_length": 1152,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001159378.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.742G>T",
"hgvs_p": "p.Ala248Ser",
"transcript": "NM_001159379.2",
"protein_id": "NP_001152851.1",
"transcript_support_level": null,
"aa_start": 248,
"aa_end": null,
"aa_length": 382,
"cds_start": 742,
"cds_end": null,
"cds_length": 1149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001159379.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.742G>T",
"hgvs_p": "p.Ala248Ser",
"transcript": "NM_022764.3",
"protein_id": "NP_073601.2",
"transcript_support_level": null,
"aa_start": 248,
"aa_end": null,
"aa_length": 382,
"cds_start": 742,
"cds_end": null,
"cds_length": 1149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_022764.3"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.685G>T",
"hgvs_p": "p.Ala229Ser",
"transcript": "NM_001159380.2",
"protein_id": "NP_001152852.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 363,
"cds_start": 685,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001159380.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.310G>T",
"hgvs_p": "p.Ala104Ser",
"transcript": "ENST00000950129.1",
"protein_id": "ENSP00000620188.1",
"transcript_support_level": null,
"aa_start": 104,
"aa_end": null,
"aa_length": 238,
"cds_start": 310,
"cds_end": null,
"cds_length": 717,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950129.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.256G>T",
"hgvs_p": "p.Ala86Ser",
"transcript": "ENST00000546093.5",
"protein_id": "ENSP00000438761.1",
"transcript_support_level": 2,
"aa_start": 86,
"aa_end": null,
"aa_length": 220,
"cds_start": 256,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000546093.5"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.685G>T",
"hgvs_p": "p.Ala229Ser",
"transcript": "XM_005256101.2",
"protein_id": "XP_005256158.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 363,
"cds_start": 685,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005256101.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.685G>T",
"hgvs_p": "p.Ala229Ser",
"transcript": "XM_011523280.3",
"protein_id": "XP_011521582.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 363,
"cds_start": 685,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011523280.3"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.685G>T",
"hgvs_p": "p.Ala229Ser",
"transcript": "XM_047434497.1",
"protein_id": "XP_047290453.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 363,
"cds_start": 685,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047434497.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.685G>T",
"hgvs_p": "p.Ala229Ser",
"transcript": "XM_047434498.1",
"protein_id": "XP_047290454.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 363,
"cds_start": 685,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047434498.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.685G>T",
"hgvs_p": "p.Ala229Ser",
"transcript": "XM_047434499.1",
"protein_id": "XP_047290455.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 363,
"cds_start": 685,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047434499.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.631G>T",
"hgvs_p": "p.Ala211Ser",
"transcript": "XM_017023571.2",
"protein_id": "XP_016879060.1",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 345,
"cds_start": 631,
"cds_end": null,
"cds_length": 1038,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017023571.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.628G>T",
"hgvs_p": "p.Ala210Ser",
"transcript": "XM_017023572.3",
"protein_id": "XP_016879061.3",
"transcript_support_level": null,
"aa_start": 210,
"aa_end": null,
"aa_length": 344,
"cds_start": 628,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017023572.3"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.370G>T",
"hgvs_p": "p.Ala124Ser",
"transcript": "XM_047434503.1",
"protein_id": "XP_047290459.1",
"transcript_support_level": null,
"aa_start": 124,
"aa_end": null,
"aa_length": 258,
"cds_start": 370,
"cds_end": null,
"cds_length": 777,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047434503.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"hgvs_c": "c.319G>T",
"hgvs_p": "p.Ala107Ser",
"transcript": "XM_047434504.1",
"protein_id": "XP_047290460.1",
"transcript_support_level": null,
"aa_start": 107,
"aa_end": null,
"aa_length": 241,
"cds_start": 319,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
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{
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"strand": false,
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],
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},
{
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"consequences": [
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],
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},
{
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"protein_coding": false,
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"consequences": [
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],
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"exon_count": 3,
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"biotype": "retained_intron",
"feature": "ENST00000562096.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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],
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"exon_count": 5,
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"gene_symbol": "MTHFSD",
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"feature": "ENST00000567539.5"
},
{
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"strand": false,
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],
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"exon_count": 1,
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"biotype": "TEC",
"feature": "ENST00000625049.1"
},
{
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"non_coding_transcript_exon_variant"
],
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"gene_symbol": "MTHFSD",
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"transcript": "NR_027489.2",
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"biotype": "pseudogene",
"feature": "NR_027489.2"
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{
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],
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"biotype": "pseudogene",
"feature": "NR_027490.2"
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 5,
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"exon_count": 5,
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"gene_symbol": "MTHFSD",
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"hgvs_c": "n.*252G>T",
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"transcript": "ENST00000567539.5",
"protein_id": "ENSP00000454593.1",
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"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
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"biotype": "nonsense_mediated_decay",
"feature": "ENST00000567539.5"
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],
"gene_symbol": "MTHFSD",
"gene_hgnc_id": 25778,
"dbsnp": "rs776250628",
"frequency_reference_population": 0.000012032713,
"hom_count_reference_population": 0,
"allele_count_reference_population": 18,
"gnomad_exomes_af": 0.0000126508,
"gnomad_genomes_af": 0.00000657307,
"gnomad_exomes_ac": 17,
"gnomad_genomes_ac": 1,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.18069010972976685,
"computational_prediction_selected": "Benign",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.112,
"revel_prediction": "Benign",
"alphamissense_score": 0.0891,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.4,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 3.15,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": 0,
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,BP4_Moderate",
"acmg_by_gene": [
{
"score": 0,
"benign_score": 2,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "NM_001159377.2",
"gene_symbol": "MTHFSD",
"hgnc_id": 25778,
"effects": [
"missense_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.745G>T",
"hgvs_p": "p.Ala249Ser"
}
],
"clinvar_disease": "not specified",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}