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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-8859224-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=8859224&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 8859224,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000311052.10",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_014316.4",
"protein_id": "NP_055131.2",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 153,
"cdna_end": null,
"cdna_length": 2709,
"mane_select": "ENST00000311052.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000311052.10",
"protein_id": "ENSP00000311847.4",
"transcript_support_level": 1,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 153,
"cdna_end": null,
"cdna_length": 2709,
"mane_select": "NM_014316.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000396593.6",
"protein_id": "ENSP00000379838.2",
"transcript_support_level": 1,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 465,
"cdna_end": null,
"cdna_length": 3026,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.131G>T",
"hgvs_p": "p.Gly44Val",
"transcript": "ENST00000568968.1",
"protein_id": "ENSP00000455988.1",
"transcript_support_level": 2,
"aa_start": 44,
"aa_end": null,
"aa_length": 113,
"cds_start": 131,
"cds_end": null,
"cds_length": 344,
"cdna_start": 248,
"cdna_end": null,
"cdna_length": 461,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001042476.2",
"protein_id": "NP_001035941.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 465,
"cdna_end": null,
"cdna_length": 3026,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001278260.2",
"protein_id": "NP_001265189.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 267,
"cdna_end": null,
"cdna_length": 2823,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001278261.2",
"protein_id": "NP_001265190.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 412,
"cdna_end": null,
"cdna_length": 2968,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001278262.2",
"protein_id": "NP_001265191.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 295,
"cdna_end": null,
"cdna_length": 2851,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001278263.1",
"protein_id": "NP_001265192.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 147,
"cdna_end": null,
"cdna_length": 2708,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001278264.2",
"protein_id": "NP_001265193.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 289,
"cdna_end": null,
"cdna_length": 2845,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001278265.2",
"protein_id": "NP_001265194.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 205,
"cdna_end": null,
"cdna_length": 2761,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "NM_001278266.2",
"protein_id": "NP_001265195.1",
"transcript_support_level": null,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 181,
"cdna_end": null,
"cdna_length": 2737,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000561530.5",
"protein_id": "ENSP00000455284.1",
"transcript_support_level": 3,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 147,
"cdna_end": null,
"cdna_length": 729,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000567554.5",
"protein_id": "ENSP00000455855.1",
"transcript_support_level": 2,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 160,
"cdna_end": null,
"cdna_length": 598,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000610831.4",
"protein_id": "ENSP00000478055.1",
"transcript_support_level": 2,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 281,
"cdna_end": null,
"cdna_length": 2841,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000611932.4",
"protein_id": "ENSP00000481550.1",
"transcript_support_level": 3,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 273,
"cdna_end": null,
"cdna_length": 2833,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000614449.4",
"protein_id": "ENSP00000480542.1",
"transcript_support_level": 5,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 371,
"cdna_end": null,
"cdna_length": 2931,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000618335.4",
"protein_id": "ENSP00000483591.1",
"transcript_support_level": 4,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
"cds_length": 444,
"cdna_start": 412,
"cdna_end": null,
"cdna_length": 2972,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000619881.4",
"protein_id": "ENSP00000480144.1",
"transcript_support_level": 3,
"aa_start": 35,
"aa_end": null,
"aa_length": 147,
"cds_start": 105,
"cds_end": null,
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"cdna_start": 289,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000565287.5",
"protein_id": "ENSP00000455016.1",
"transcript_support_level": 3,
"aa_start": 35,
"aa_end": null,
"aa_length": 130,
"cds_start": 105,
"cds_end": null,
"cds_length": 394,
"cdna_start": 267,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000567908.5",
"protein_id": "ENSP00000455522.1",
"transcript_support_level": 2,
"aa_start": 35,
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"cds_start": 105,
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"cdna_start": 293,
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"cdna_length": 565,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000570125.5",
"protein_id": "ENSP00000457864.1",
"transcript_support_level": 4,
"aa_start": 35,
"aa_end": null,
"aa_length": 123,
"cds_start": 105,
"cds_end": null,
"cds_length": 374,
"cdna_start": 412,
"cdna_end": null,
"cdna_length": 681,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARHSP1",
"gene_hgnc_id": 17150,
"hgvs_c": "c.105G>T",
"hgvs_p": "p.Arg35Arg",
"transcript": "ENST00000568117.5",
"protein_id": "ENSP00000456909.1",
"transcript_support_level": 3,
"aa_start": 35,
"aa_end": null,
"aa_length": 111,
"cds_start": 105,
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}
],
"message": null
}