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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-8901027-GCT-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=8901027&ref=GCT&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "16",
      "pos": 8901027,
      "ref": "GCT",
      "alt": "G",
      "effect": "frameshift_variant",
      "transcript": "NM_003470.3",
      "consequences": [
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2169_2170delAG",
          "hgvs_p": "p.Arg723fs",
          "transcript": "NM_003470.3",
          "protein_id": "NP_003461.2",
          "transcript_support_level": null,
          "aa_start": 723,
          "aa_end": null,
          "aa_length": 1102,
          "cds_start": 2169,
          "cds_end": null,
          "cds_length": 3309,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000344836.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_003470.3"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2169_2170delAG",
          "hgvs_p": "p.Arg723fs",
          "transcript": "ENST00000344836.9",
          "protein_id": "ENSP00000343535.4",
          "transcript_support_level": 1,
          "aa_start": 723,
          "aa_end": null,
          "aa_length": 1102,
          "cds_start": 2169,
          "cds_end": null,
          "cds_length": 3309,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_003470.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000344836.9"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2121_2122delAG",
          "hgvs_p": "p.Arg707fs",
          "transcript": "ENST00000381886.8",
          "protein_id": "ENSP00000371310.4",
          "transcript_support_level": 1,
          "aa_start": 707,
          "aa_end": null,
          "aa_length": 1086,
          "cds_start": 2121,
          "cds_end": null,
          "cds_length": 3261,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000381886.8"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2274_2275delAG",
          "hgvs_p": "p.Arg758fs",
          "transcript": "ENST00000673704.1",
          "protein_id": "ENSP00000501290.1",
          "transcript_support_level": null,
          "aa_start": 758,
          "aa_end": null,
          "aa_length": 1137,
          "cds_start": 2274,
          "cds_end": null,
          "cds_length": 3414,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000673704.1"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2205_2206delAG",
          "hgvs_p": "p.Arg735fs",
          "transcript": "ENST00000923082.1",
          "protein_id": "ENSP00000593141.1",
          "transcript_support_level": null,
          "aa_start": 735,
          "aa_end": null,
          "aa_length": 1114,
          "cds_start": 2205,
          "cds_end": null,
          "cds_length": 3345,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923082.1"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2199_2200delAG",
          "hgvs_p": "p.Arg733fs",
          "transcript": "ENST00000923081.1",
          "protein_id": "ENSP00000593140.1",
          "transcript_support_level": null,
          "aa_start": 733,
          "aa_end": null,
          "aa_length": 1112,
          "cds_start": 2199,
          "cds_end": null,
          "cds_length": 3339,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923081.1"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2166_2167delAG",
          "hgvs_p": "p.Arg722fs",
          "transcript": "ENST00000923079.1",
          "protein_id": "ENSP00000593138.1",
          "transcript_support_level": null,
          "aa_start": 722,
          "aa_end": null,
          "aa_length": 1101,
          "cds_start": 2166,
          "cds_end": null,
          "cds_length": 3306,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923079.1"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2169_2170delAG",
          "hgvs_p": "p.Arg723fs",
          "transcript": "ENST00000923078.1",
          "protein_id": "ENSP00000593137.1",
          "transcript_support_level": null,
          "aa_start": 723,
          "aa_end": null,
          "aa_length": 1100,
          "cds_start": 2169,
          "cds_end": null,
          "cds_length": 3303,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923078.1"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2121_2122delAG",
          "hgvs_p": "p.Arg707fs",
          "transcript": "NM_001286457.2",
          "protein_id": "NP_001273386.2",
          "transcript_support_level": null,
          "aa_start": 707,
          "aa_end": null,
          "aa_length": 1086,
          "cds_start": 2121,
          "cds_end": null,
          "cds_length": 3261,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001286457.2"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2169_2170delAG",
          "hgvs_p": "p.Arg723fs",
          "transcript": "ENST00000969523.1",
          "protein_id": "ENSP00000639582.1",
          "transcript_support_level": null,
          "aa_start": 723,
          "aa_end": null,
          "aa_length": 1078,
          "cds_start": 2169,
          "cds_end": null,
          "cds_length": 3237,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969523.1"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.2064_2065delAG",
          "hgvs_p": "p.Arg688fs",
          "transcript": "ENST00000923080.1",
          "protein_id": "ENSP00000593139.1",
          "transcript_support_level": null,
          "aa_start": 688,
          "aa_end": null,
          "aa_length": 1067,
          "cds_start": 2064,
          "cds_end": null,
          "cds_length": 3204,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923080.1"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.1995_1996delAG",
          "hgvs_p": "p.Arg665fs",
          "transcript": "NM_001321858.2",
          "protein_id": "NP_001308787.1",
          "transcript_support_level": null,
          "aa_start": 665,
          "aa_end": null,
          "aa_length": 1044,
          "cds_start": 1995,
          "cds_end": null,
          "cds_length": 3135,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001321858.2"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.1872_1873delAG",
          "hgvs_p": "p.Arg624fs",
          "transcript": "NM_001286458.2",
          "protein_id": "NP_001273387.1",
          "transcript_support_level": null,
          "aa_start": 624,
          "aa_end": null,
          "aa_length": 1003,
          "cds_start": 1872,
          "cds_end": null,
          "cds_length": 3012,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001286458.2"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.1872_1873delAG",
          "hgvs_p": "p.Arg624fs",
          "transcript": "ENST00000563085.5",
          "protein_id": "ENSP00000454795.1",
          "transcript_support_level": 2,
          "aa_start": 624,
          "aa_end": null,
          "aa_length": 908,
          "cds_start": 1872,
          "cds_end": null,
          "cds_length": 2728,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000563085.5"
        },
        {
          "aa_ref": "RA",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "c.1995_1996delAG",
          "hgvs_p": "p.Arg665fs",
          "transcript": "XM_047434605.1",
          "protein_id": "XP_047290561.1",
          "transcript_support_level": null,
          "aa_start": 665,
          "aa_end": null,
          "aa_length": 1044,
          "cds_start": 1995,
          "cds_end": null,
          "cds_length": 3135,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047434605.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.*1754_*1755delAG",
          "hgvs_p": null,
          "transcript": "ENST00000563961.5",
          "protein_id": "ENSP00000454362.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000563961.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.*2152_*2153delAG",
          "hgvs_p": null,
          "transcript": "ENST00000565455.5",
          "protein_id": "ENSP00000456258.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000565455.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.107_108delAG",
          "hgvs_p": null,
          "transcript": "ENST00000569448.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000569448.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.2150_2151delAG",
          "hgvs_p": null,
          "transcript": "NR_135826.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "NR_135826.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.*1754_*1755delAG",
          "hgvs_p": null,
          "transcript": "ENST00000563961.5",
          "protein_id": "ENSP00000454362.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000563961.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.*2152_*2153delAG",
          "hgvs_p": null,
          "transcript": "ENST00000565455.5",
          "protein_id": "ENSP00000456258.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000565455.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.64+113_64+114delAG",
          "hgvs_p": null,
          "transcript": "ENST00000563043.1",
          "protein_id": "ENSP00000459594.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000563043.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.43+113_43+114delAG",
          "hgvs_p": null,
          "transcript": "ENST00000567692.1",
          "protein_id": "ENSP00000458027.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000567692.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "USP7",
          "gene_hgnc_id": 12630,
          "hgvs_c": "n.-109_-108delAG",
          "hgvs_p": null,
          "transcript": "ENST00000566131.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000566131.1"
        }
      ],
      "gene_symbol": "USP7",
      "gene_hgnc_id": 12630,
      "dbsnp": "rs1555462347",
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 8.017,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 12,
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PVS1,PM2,PP5_Moderate",
      "acmg_by_gene": [
        {
          "score": 12,
          "benign_score": 0,
          "pathogenic_score": 12,
          "criteria": [
            "PVS1",
            "PM2",
            "PP5_Moderate"
          ],
          "verdict": "Pathogenic",
          "transcript": "NM_003470.3",
          "gene_symbol": "USP7",
          "hgnc_id": 12630,
          "effects": [
            "frameshift_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.2169_2170delAG",
          "hgvs_p": "p.Arg723fs"
        }
      ],
      "clinvar_disease": "Hao-Fountain syndrome,USP7-related disorder",
      "clinvar_classification": "Likely pathogenic",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LP:1",
      "phenotype_combined": "USP7-related disorder|Hao-Fountain syndrome",
      "pathogenicity_classification_combined": "Likely pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}