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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 16-89544764-ACG-CGC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=89544764&ref=ACG&alt=CGC&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PP3"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "SPG7",
          "hgnc_id": 11237,
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "inheritance_mode": "AR,AD",
          "pathogenic_score": 1,
          "score": 1,
          "transcript": "NM_001363850.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PP3",
      "acmg_score": 1,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "CGC",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "16",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 795,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3076,
          "cdna_start": 1456,
          "cds_end": null,
          "cds_length": 2388,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_003119.4",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000645818.2",
          "protein_coding": true,
          "protein_id": "NP_003110.1",
          "strand": true,
          "transcript": "NM_003119.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 795,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3076,
          "cdna_start": 1456,
          "cds_end": null,
          "cds_length": 2388,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000645818.2",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_003119.4",
          "protein_coding": true,
          "protein_id": "ENSP00000495795.2",
          "strand": true,
          "transcript": "ENST00000645818.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 788,
          "aa_ref": "T",
          "aa_start": 474,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3026,
          "cdna_start": 1428,
          "cds_end": null,
          "cds_length": 2367,
          "cds_start": 1420,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000268704.7",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1420_1422delACGinsCGC",
          "hgvs_p": "p.Thr474Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000268704.3",
          "strand": true,
          "transcript": "ENST00000268704.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 825,
          "aa_ref": "T",
          "aa_start": 511,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3149,
          "cdna_start": 1531,
          "cds_end": null,
          "cds_length": 2478,
          "cds_start": 1531,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000918773.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1531_1533delACGinsCGC",
          "hgvs_p": "p.Thr511Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000588832.1",
          "strand": true,
          "transcript": "ENST00000918773.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 820,
          "aa_ref": "T",
          "aa_start": 506,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3147,
          "cdna_start": 1531,
          "cds_end": null,
          "cds_length": 2463,
          "cds_start": 1516,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000892261.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1516_1518delACGinsCGC",
          "hgvs_p": "p.Thr506Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000562320.1",
          "strand": true,
          "transcript": "ENST00000892261.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 809,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3301,
          "cdna_start": 1471,
          "cds_end": null,
          "cds_length": 2430,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001363850.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001350779.1",
          "strand": true,
          "transcript": "NM_001363850.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 809,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3266,
          "cdna_start": 1456,
          "cds_end": null,
          "cds_length": 2430,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000645063.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000493590.1",
          "strand": true,
          "transcript": "ENST00000645063.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 809,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3108,
          "cdna_start": 1456,
          "cds_end": null,
          "cds_length": 2430,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000965633.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000635692.1",
          "strand": true,
          "transcript": "ENST00000965633.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 807,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3104,
          "cdna_start": 1457,
          "cds_end": null,
          "cds_length": 2424,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000965632.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000635691.1",
          "strand": true,
          "transcript": "ENST00000965632.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 794,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3081,
          "cdna_start": 1464,
          "cds_end": null,
          "cds_length": 2385,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000918772.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000588831.1",
          "strand": true,
          "transcript": "ENST00000918772.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 781,
          "aa_ref": "T",
          "aa_start": 467,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3051,
          "cdna_start": 1440,
          "cds_end": null,
          "cds_length": 2346,
          "cds_start": 1399,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000918771.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1399_1401delACGinsCGC",
          "hgvs_p": "p.Thr467Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000588830.1",
          "strand": true,
          "transcript": "ENST00000918771.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 780,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3012,
          "cdna_start": 1456,
          "cds_end": null,
          "cds_length": 2343,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000644781.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000495473.1",
          "strand": true,
          "transcript": "ENST00000644781.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 758,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2507,
          "cdna_start": 1492,
          "cds_end": null,
          "cds_length": 2277,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000643649.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000494806.1",
          "strand": true,
          "transcript": "ENST00000643649.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 751,
          "aa_ref": "T",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3099,
          "cdna_start": 1497,
          "cds_end": null,
          "cds_length": 2256,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000646303.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1309_1311delACGinsCGC",
          "hgvs_p": "p.Thr437Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000494160.1",
          "strand": true,
          "transcript": "ENST00000646303.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 730,
          "aa_ref": "T",
          "aa_start": 416,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2872,
          "cdna_start": 1260,
          "cds_end": null,
          "cds_length": 2193,
          "cds_start": 1246,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000892262.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1246_1248delACGinsCGC",
          "hgvs_p": "p.Thr416Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000562321.1",
          "strand": true,
          "transcript": "ENST00000892262.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 687,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2750,
          "cdna_start": 1455,
          "cds_end": null,
          "cds_length": 2064,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 15,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000965630.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1441_1443delACGinsCGC",
          "hgvs_p": "p.Thr481Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000635689.1",
          "strand": true,
          "transcript": "ENST00000965630.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 680,
          "aa_ref": "T",
          "aa_start": 366,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2689,
          "cdna_start": 1098,
          "cds_end": null,
          "cds_length": 2043,
          "cds_start": 1096,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 15,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000644671.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1096_1098delACGinsCGC",
          "hgvs_p": "p.Thr366Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000495999.1",
          "strand": true,
          "transcript": "ENST00000644671.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 672,
          "aa_ref": "T",
          "aa_start": 358,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2701,
          "cdna_start": 1085,
          "cds_end": null,
          "cds_length": 2019,
          "cds_start": 1072,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 14,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000965631.1",
          "gene_hgnc_id": 11237,
          "gene_symbol": "SPG7",
          "hgvs_c": "c.1072_1074delACGinsCGC",
          "hgvs_p": "p.Thr358Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000635690.1",
          "strand": true,
          "transcript": "ENST00000965631.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 661,
          "aa_ref": "T",
          "aa_start": 481,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2661,
          "cdna_start": 1455,
          "cds_end": null,
          "cds_length": 1986,
          "cds_start": 1441,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 14,
          "exon_rank": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.