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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-16444101-TGG-CCT (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=16444101&ref=TGG&alt=CCT&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "LRRC75A",
          "hgnc_id": 32403,
          "hgvs_c": "c.520_522delCCAinsAGG",
          "hgvs_p": "p.Pro174Arg",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_001113567.3",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "SNHG29",
          "hgnc_id": 28619,
          "hgvs_c": "n.181+3848_181+3850delTGGinsCCT",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "ENST00000581361.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "CCT",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "17",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 344,
          "aa_ref": "P",
          "aa_start": 174,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3249,
          "cdna_start": 725,
          "cds_end": null,
          "cds_length": 1035,
          "cds_start": 520,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001113567.3",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.520_522delCCAinsAGG",
          "hgvs_p": "p.Pro174Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000470794.2",
          "protein_coding": true,
          "protein_id": "NP_001107039.1",
          "strand": false,
          "transcript": "NM_001113567.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 344,
          "aa_ref": "P",
          "aa_start": 174,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3249,
          "cdna_start": 725,
          "cds_end": null,
          "cds_length": 1035,
          "cds_start": 520,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000470794.2",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.520_522delCCAinsAGG",
          "hgvs_p": "p.Pro174Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001113567.3",
          "protein_coding": true,
          "protein_id": "ENSP00000419502.1",
          "strand": false,
          "transcript": "ENST00000470794.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3157,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000409887.3",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "n.631_633delCCAinsAGG",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000409887.3",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 843,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000581361.5",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.181+3848_181+3850delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000581361.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 354,
          "aa_ref": "P",
          "aa_start": 184,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2817,
          "cdna_start": 734,
          "cds_end": null,
          "cds_length": 1065,
          "cds_start": 550,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000934493.1",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.550_552delCCAinsAGG",
          "hgvs_p": "p.Pro184Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000604552.1",
          "strand": false,
          "transcript": "ENST00000934493.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 301,
          "aa_ref": "P",
          "aa_start": 131,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2906,
          "cdna_start": 640,
          "cds_end": null,
          "cds_length": 906,
          "cds_start": 391,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000934492.1",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.391_393delCCAinsAGG",
          "hgvs_p": "p.Pro131Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000604551.1",
          "strand": false,
          "transcript": "ENST00000934492.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "QG",
          "aa_end": null,
          "aa_length": 212,
          "aa_ref": "PR",
          "aa_start": 135,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3133,
          "cdna_start": 609,
          "cds_end": null,
          "cds_length": 639,
          "cds_start": 404,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_207387.4",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.404_406delCCAinsAGG",
          "hgvs_p": "p.ProArg135GlnGly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_997270.2",
          "strand": false,
          "transcript": "NM_207387.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "QG",
          "aa_end": null,
          "aa_length": 212,
          "aa_ref": "PR",
          "aa_start": 135,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2656,
          "cdna_start": 569,
          "cds_end": null,
          "cds_length": 639,
          "cds_start": 404,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000409083.7",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.404_406delCCAinsAGG",
          "hgvs_p": "p.ProArg135GlnGly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000386504.3",
          "strand": false,
          "transcript": "ENST00000409083.7",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 329,
          "aa_ref": "P",
          "aa_start": 159,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3143,
          "cdna_start": 619,
          "cds_end": null,
          "cds_length": 990,
          "cds_start": 475,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_017024619.2",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.475_477delCCAinsAGG",
          "hgvs_p": "p.Pro159Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016880108.1",
          "strand": false,
          "transcript": "XM_017024619.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 302,
          "aa_ref": "P",
          "aa_start": 132,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3633,
          "cdna_start": 1109,
          "cds_end": null,
          "cds_length": 909,
          "cds_start": 394,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_017024620.2",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.394_396delCCAinsAGG",
          "hgvs_p": "p.Pro132Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016880109.1",
          "strand": false,
          "transcript": "XM_017024620.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 259,
          "aa_ref": "P",
          "aa_start": 89,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3510,
          "cdna_start": 986,
          "cds_end": null,
          "cds_length": 780,
          "cds_start": 265,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047435961.1",
          "gene_hgnc_id": 32403,
          "gene_symbol": "LRRC75A",
          "hgvs_c": "c.265_267delCCAinsAGG",
          "hgvs_p": "p.Pro89Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047291917.1",
          "strand": false,
          "transcript": "XM_047435961.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 818,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000472367.6",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.357+3848_357+3850delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 4,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000472367.6",
          "transcript_support_level": 3
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 872,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000478103.7",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.414+2971_414+2973delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 5,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000478103.7",
          "transcript_support_level": 3
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 712,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000483588.3",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.181+3848_181+3850delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000483588.3",
          "transcript_support_level": 3
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 906,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000578380.7",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.448+2971_448+2973delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 5,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000578380.7",
          "transcript_support_level": 3
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3206,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000579473.6",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.238+2971_238+2973delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 4,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000579473.6",
          "transcript_support_level": 4
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 572,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000580770.5",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.238+2971_238+2973delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 4,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000580770.5",
          "transcript_support_level": 4
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3293,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000581718.6",
          "gene_hgnc_id": 28619,
          "gene_symbol": "SNHG29",
          "hgvs_c": "n.504+2971_504+2973delTGGinsCCT",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000581718.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3310,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000583400.7",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.