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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-1745341-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=1745341&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "SERPINF2",
          "hgnc_id": 9075,
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "inheritance_mode": "AR,AD",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "NM_000934.4",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_score": 0,
      "allele_count_reference_population": 2,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.1118,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.27,
      "chr": "17",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.14629149436950684,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2249,
          "cdna_start": 153,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_000934.4",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000453066.6",
          "protein_coding": true,
          "protein_id": "NP_000925.2",
          "strand": true,
          "transcript": "NM_000934.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2249,
          "cdna_start": 153,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000453066.6",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_000934.4",
          "protein_coding": true,
          "protein_id": "ENSP00000402286.2",
          "strand": true,
          "transcript": "ENST00000453066.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2262,
          "cdna_start": 166,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000382061.5",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000371493.4",
          "strand": true,
          "transcript": "ENST00000382061.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 545,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2417,
          "cdna_start": 159,
          "cds_end": null,
          "cds_length": 1638,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883620.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553679.1",
          "strand": true,
          "transcript": "ENST00000883620.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 531,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2414,
          "cdna_start": 196,
          "cds_end": null,
          "cds_length": 1596,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883601.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553660.1",
          "strand": true,
          "transcript": "ENST00000883601.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 531,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2636,
          "cdna_start": 420,
          "cds_end": null,
          "cds_length": 1596,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000883615.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553674.1",
          "strand": true,
          "transcript": "ENST00000883615.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 531,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2526,
          "cdna_start": 310,
          "cds_end": null,
          "cds_length": 1596,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883646.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553705.1",
          "strand": true,
          "transcript": "ENST00000883646.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 526,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2354,
          "cdna_start": 153,
          "cds_end": null,
          "cds_length": 1581,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883634.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553693.1",
          "strand": true,
          "transcript": "ENST00000883634.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 507,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2328,
          "cdna_start": 181,
          "cds_end": null,
          "cds_length": 1524,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883608.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553667.1",
          "strand": true,
          "transcript": "ENST00000883608.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2262,
          "cdna_start": 166,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001165920.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001159392.1",
          "strand": true,
          "transcript": "NM_001165920.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2284,
          "cdna_start": 188,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000324015.7",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000321853.3",
          "strand": true,
          "transcript": "ENST00000324015.7",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2292,
          "cdna_start": 196,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883591.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553650.1",
          "strand": true,
          "transcript": "ENST00000883591.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2608,
          "cdna_start": 506,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000883592.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553651.1",
          "strand": true,
          "transcript": "ENST00000883592.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2556,
          "cdna_start": 455,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000883594.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553653.1",
          "strand": true,
          "transcript": "ENST00000883594.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2610,
          "cdna_start": 514,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000883595.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553654.1",
          "strand": true,
          "transcript": "ENST00000883595.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2636,
          "cdna_start": 541,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000883597.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553656.1",
          "strand": true,
          "transcript": "ENST00000883597.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2385,
          "cdna_start": 286,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883600.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553659.1",
          "strand": true,
          "transcript": "ENST00000883600.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2313,
          "cdna_start": 217,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000883602.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553661.1",
          "strand": true,
          "transcript": "ENST00000883602.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "S",
          "aa_start": 37,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2608,
          "cdna_start": 512,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 111,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000883605.1",
          "gene_hgnc_id": 9075,
          "gene_symbol": "SERPINF2",
          "hgvs_c": "c.111C>G",
          "hgvs_p": "p.Ser37Arg",
          "intron_rank": null,
          "intron_rank_end": null,
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  ]
}
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