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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-19357821-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=19357821&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 19357821,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000261499.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "NM_015681.6",
"protein_id": "NP_056496.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 204,
"cds_start": -4,
"cds_end": null,
"cds_length": 615,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 913,
"mane_select": "ENST00000261499.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "ENST00000261499.11",
"protein_id": "ENSP00000261499.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 204,
"cds_start": -4,
"cds_end": null,
"cds_length": 615,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 913,
"mane_select": "NM_015681.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "ENST00000268841.10",
"protein_id": "ENSP00000268841.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 153,
"cds_start": -4,
"cds_end": null,
"cds_length": 462,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 755,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "ENST00000477683.5",
"protein_id": "ENSP00000494660.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 135,
"cds_start": -4,
"cds_end": null,
"cds_length": 408,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 618,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "ENST00000663089.1",
"protein_id": "ENSP00000499469.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 204,
"cds_start": -4,
"cds_end": null,
"cds_length": 615,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3480,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "NM_001321214.2",
"protein_id": "NP_001308143.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1120,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "ENST00000395616.7",
"protein_id": "ENSP00000378978.3",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 733,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "ENST00000671102.1",
"protein_id": "ENSP00000499690.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3617,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "NM_001321217.2",
"protein_id": "NP_001308146.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 186,
"cds_start": -4,
"cds_end": null,
"cds_length": 561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1034,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "ENST00000461069.6",
"protein_id": "ENSP00000433359.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 186,
"cds_start": -4,
"cds_end": null,
"cds_length": 561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 923,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "NM_001321215.3",
"protein_id": "NP_001308144.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 183,
"cds_start": -4,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "B9D1",
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"hgvs_c": "c.244+19T>G",
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"transcript": "ENST00000647252.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
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"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "NM_001321218.2",
"protein_id": "NP_001308147.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.244+19T>G",
"hgvs_p": null,
"transcript": "NM_001330149.2",
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},
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],
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"transcript": "NM_001321219.2",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "B9D1",
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"hgvs_c": "c.244+19T>G",
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"transcript": "ENST00000675510.1",
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},
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],
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"gene_symbol": "B9D1",
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"hgvs_c": "c.244+19T>G",
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"transcript": "NM_001321216.2",
"protein_id": "NP_001308145.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.217+19T>G",
"hgvs_p": null,
"transcript": "ENST00000440841.1",
"protein_id": "ENSP00000410835.1",
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"aa_start": null,
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},
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "B9D1",
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"hgvs_c": "c.69+19T>G",
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},
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],
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},
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],
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},
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"consequences": [
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "B9D1",
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"hgvs_c": "c.-117+19T>G",
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"transcript": "ENST00000477478.7",
"protein_id": "ENSP00000460939.2",
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"biotype": null,
"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 3,
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"gene_symbol": "B9D1",
"gene_hgnc_id": 24123,
"hgvs_c": "c.-117+19T>G",
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"transcript": "ENST00000575478.7",
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},
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}