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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-19380842-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=19380842&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 19380842,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000395604.8",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "NM_002749.4",
"protein_id": "NP_002740.2",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 771,
"cdna_end": null,
"cdna_length": 2902,
"mane_select": "ENST00000395604.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "ENST00000395604.8",
"protein_id": "ENSP00000378968.3",
"transcript_support_level": 1,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 771,
"cdna_end": null,
"cdna_length": 2902,
"mane_select": "NM_002749.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "ENST00000308406.9",
"protein_id": "ENSP00000311005.5",
"transcript_support_level": 1,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 1019,
"cdna_end": null,
"cdna_length": 3149,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "ENST00000395602.8",
"protein_id": "ENSP00000378966.4",
"transcript_support_level": 1,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 928,
"cdna_end": null,
"cdna_length": 3059,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.216C>A",
"hgvs_p": "p.Pro72Pro",
"transcript": "ENST00000299612.11",
"protein_id": "ENSP00000299612.7",
"transcript_support_level": 1,
"aa_start": 72,
"aa_end": null,
"aa_length": 677,
"cds_start": 216,
"cds_end": null,
"cds_length": 2034,
"cdna_start": 584,
"cdna_end": null,
"cdna_length": 2715,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "NM_139033.3",
"protein_id": "NP_620602.2",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 990,
"cdna_end": null,
"cdna_length": 3121,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "NM_139034.3",
"protein_id": "NP_620603.2",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 683,
"cdna_end": null,
"cdna_length": 2814,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.216C>A",
"hgvs_p": "p.Pro72Pro",
"transcript": "NM_139032.3",
"protein_id": "NP_620601.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 677,
"cds_start": 216,
"cds_end": null,
"cds_length": 2034,
"cdna_start": 587,
"cdna_end": null,
"cdna_length": 2718,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "ENST00000443215.5",
"protein_id": "ENSP00000412902.1",
"transcript_support_level": 3,
"aa_start": 211,
"aa_end": null,
"aa_length": 240,
"cds_start": 633,
"cds_end": null,
"cds_length": 724,
"cdna_start": 759,
"cdna_end": null,
"cdna_length": 850,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.216C>A",
"hgvs_p": "p.Pro72Pro",
"transcript": "ENST00000482850.1",
"protein_id": "ENSP00000458146.1",
"transcript_support_level": 2,
"aa_start": 72,
"aa_end": null,
"aa_length": 194,
"cds_start": 216,
"cds_end": null,
"cds_length": 587,
"cdna_start": 269,
"cdna_end": null,
"cdna_length": 640,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.651C>A",
"hgvs_p": "p.Pro217Pro",
"transcript": "XM_006721557.4",
"protein_id": "XP_006721620.1",
"transcript_support_level": null,
"aa_start": 217,
"aa_end": null,
"aa_length": 822,
"cds_start": 651,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 789,
"cdna_end": null,
"cdna_length": 2920,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.651C>A",
"hgvs_p": "p.Pro217Pro",
"transcript": "XM_006721558.4",
"protein_id": "XP_006721621.1",
"transcript_support_level": null,
"aa_start": 217,
"aa_end": null,
"aa_length": 822,
"cds_start": 651,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 1008,
"cdna_end": null,
"cdna_length": 3139,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.651C>A",
"hgvs_p": "p.Pro217Pro",
"transcript": "XM_006721559.4",
"protein_id": "XP_006721622.1",
"transcript_support_level": null,
"aa_start": 217,
"aa_end": null,
"aa_length": 822,
"cds_start": 651,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 701,
"cdna_end": null,
"cdna_length": 2832,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.651C>A",
"hgvs_p": "p.Pro217Pro",
"transcript": "XM_047436401.1",
"protein_id": "XP_047292357.1",
"transcript_support_level": null,
"aa_start": 217,
"aa_end": null,
"aa_length": 822,
"cds_start": 651,
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"cdna_start": 782,
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"cdna_length": 2913,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.651C>A",
"hgvs_p": "p.Pro217Pro",
"transcript": "XM_047436402.1",
"protein_id": "XP_047292358.1",
"transcript_support_level": null,
"aa_start": 217,
"aa_end": null,
"aa_length": 822,
"cds_start": 651,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 885,
"cdna_end": null,
"cdna_length": 3016,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.651C>A",
"hgvs_p": "p.Pro217Pro",
"transcript": "XM_047436403.1",
"protein_id": "XP_047292359.1",
"transcript_support_level": null,
"aa_start": 217,
"aa_end": null,
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"cds_start": 651,
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"cdna_start": 797,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "XM_047436404.1",
"protein_id": "XP_047292360.1",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 1036,
"cdna_end": null,
"cdna_length": 3167,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "XM_047436405.1",
"protein_id": "XP_047292361.1",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 779,
"cdna_end": null,
"cdna_length": 2910,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "XM_047436406.1",
"protein_id": "XP_047292362.1",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 816,
"cds_start": 633,
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"cdna_start": 867,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.633C>A",
"hgvs_p": "p.Pro211Pro",
"transcript": "XM_047436407.1",
"protein_id": "XP_047292363.1",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 766,
"cds_start": 633,
"cds_end": null,
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"cdna_start": 771,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "c.216C>A",
"hgvs_p": "p.Pro72Pro",
"transcript": "XM_011523957.4",
"protein_id": "XP_011522259.1",
"transcript_support_level": null,
"aa_start": 72,
"aa_end": null,
"aa_length": 677,
"cds_start": 216,
"cds_end": null,
"cds_length": 2034,
"cdna_start": 280,
"cdna_end": null,
"cdna_length": 2411,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "n.642C>A",
"hgvs_p": null,
"transcript": "ENST00000490660.2",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2867,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAPK7",
"gene_hgnc_id": 6880,
"hgvs_c": "n.2314C>A",
"hgvs_p": null,
"transcript": "ENST00000570306.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
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"clinvar_disease": "",
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}
],
"message": null
}